A 90-day subchronic toxicological assessment of Antrodia cinnamomea in Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 49, Issue 2, 2011, Pages 429-433

  Chen, Tai I ^a   Chen, Chin Chu ^a   Lin, Ting Wei ^a   Tsai, Yueh Ting ^b   Nam, Mun Kit ^b  

^a Grape King Biotechnology Inc   (Taiwan)

^b Super Laboratory Inc   (Taiwan)

Author keywords

90 Day subchronic toxicity; Antrodia cinnamomea; NOAEL; Safety assessment

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTRODIA CINNAMOMEA; ARTICLE; AUTOPSY; BLOOD ANALYSIS; BLOOD CHEMISTRY; BODY WEIGHT; CHRONIC TOXICITY; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOOD ANALYSIS; FOOD POISONING; FOOD SAFETY; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; REVERSE OSMOSIS; SPRAGUE DAWLEY RAT; URINALYSIS; VISUAL SYSTEM EXAMINATION;

ANIMALS; ANTRODIA; BIOLOGICAL PRODUCTS; FEMALE; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; WEIGHT GAIN;

ANIMALIA; ANTRODIA CINNAMOMEA; BASIDIOMYCOTA; RATTUS;

EID: 78951491452     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.11.018     Document Type: Article

References (17)

1. AOAC, Official Methods of Analysis, 16th ed., Association of Official Analytical Chemists, Washington, DC, 1995.
2. Chang T.T., Chou W.N. Antrodia cinnamomea sp. nov. on Cinnamomum kanehirai in Taiwan. Mycology Research 1995, 99:756-758.
3. Chen, C.C. 2007. Functional activities and safety of Antrodia camphorate. Ph.D. thesis, National Tsing Hua University, Hsinchu, Taiwan.
4. Chen C.C., Lin W.H., Chen C.N., Hsu S.J., Huang S.C., Chen Y.L. Development of Antrodia camphorata mycelium with submerge culture. Fungi Science 2001, 16:7-22.
5. Hseu Y.C., Chen S.C., Tsai P.C., Chen C.S., Lu F.J., Chang N.W., Yang H.L. Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata. Food and Chemical Toxicology 2006, 45:1107-1115.
6. Huang G.J., Huang S.S., Lin S.S., Shao Y.Y., Chen C.C., Hou W.C., Kuo Y.H. Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3β-ol from Antrodia camphorate submerged whole broth in mice. Journal of Agricultural and Food Chemistry 2010, 58:7445-7452.
7. Huang, L.C., Mau, J.L., 2000. Antioxidant properties and polysaccharide composition analysis of Antrodia camphorate and Agaricus blazei. M.Sc. thesis, National Chung Hsing University, Taichung, Taiwan.
8. Liu D.Z., Liang Y.C., Lin S.Y., Lin Y.S., Wu W.C., Hou W.C., Su C.H. Antihypertensive activities of a solid-state culture of Taiwanofungus camphorates (Chang-Chih) in spontaneously hypertensive rats. Bioscience Biotechnology Biochemistry 2007, 71:23-30.
9. Liu J.J., Huang T.S., Hsu M.L., Chen C.C., Lin W.S., Lu F.J., Chang W.H. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicology and Applied Pharmacology 2004, 201:186-193.
10. Lu Y.C., Huang C.C., Huang C.J., Chu S.T., Chi C.C., Su H.H., Hsu S.S., Wang J.L., Chen I.S., Liu S.I., Huang J.K., Ho C.M., Kuo S.J., Jan C.R. Effects of Antrodia camphorate on viability, apoptosis, [Ca2+]I, and MAPKs phosphorylation in MG63 human osteosarcoma cells. Drug Development Research 2007, 68:71-78.
11. Mattila P., Salo-Vaananen P., Konko K. Basic composition and amino acid content of mushrooms cultivated in Finland. Journal of Agricultural and Food Chemistry 2002, 50:6419-6422.
12. OECD, 1998. 90-Day Oral Toxicity Studies in Rodents. OECD 408.
13. Shen C.C., Yang H.C., Huang R.L., Chen C.C., Chen C.C. Anti-HBV principle from the culture broth of Antrodia camphorate (Strain CCRC-35396). Journal of Chinese Medicine 2005, 16:57-61.
14. Song T.Y., Yen G.C. Antioxidant properties of Antrodia camphorate in submerged culture. Journal of Agricultural and Food Chemistry 2002, 50:3322-3327.
15. Song T.Y., Yen G.C. Protective effects of fermented filtrate from Antrodia camphorate in submerged culture against CCl4-induced hepatic toxicity in rats. Journal of Agriculture and Food Chemistry 2003, 51:1571-1577.
16. Tsai Z.T., Liaw S.L. The Use and the Effect of Ganoderma 1985, San Yun Press, Taichung, Taiwan, p. 116.
17. Yang H.L., Chen C., Chang W.H., Lu F.J., Lai Y.C., Chen C.C., Hseu T.H., Kuo C.T., Hseu Y.C. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorate. Cancer Letters 2006, 231:215-227.