Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A

Archives of Toxicology

Volumn 83, Issue 2, 2009, Pages 121-129

  Lu, Mei Chin ^a   Du, Ying Chi ^a   Chuu, Jiunn Jye ^b   Hwang, Shiuh Lin ^c   Hsieh, Pao Chuan ^d   Hung, Chih Sheng ^a   Chang, Fang Rong ^a   Wu, Yang Chang ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Antrodia camphorata (AC); Death receptor (DR); Histone acetylation; Nuclear factor B (NF B); Trichostatin A (TSA); Zhankuic acid A

Indexed keywords

ANTINEOPLASTIC AGENT; ANTRODIA CAMPHORATA EXTRACT; DEATH RECEPTOR; DNA; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG; ZHANKUIC ACID A;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ANTRODIA CAMPHORATA; APHYLLOPHORALES; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL GROWTH; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; FLOW CYTOMETRY; FRUITING BODY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING;

ANTRODIA; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HISTONES; HL-60 CELLS; HUMANS; HYDROXAMIC ACIDS; LEUKEMIA; NF-KAPPA B; PLANT EXTRACTS; RECEPTORS, DEATH DOMAIN;

ANTRODIA; TAIWANOFUNGUS CAMPHORATUS;

EID: 60449104605     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0337-3     Document Type: Article

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