Methyl antcinate a from antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and bax-triggered mitochondrial pathway

Chemical Research in Toxicology

Volumn 23, Issue 7, 2010, Pages 1256-1267

  Hsieh, Yun Chih ^a   Rao, Yerra Koteswara ^b   Wu, Chun Chi ^c   Huang, Chi Ying F ^d   Geethangili, Madamanchi ^b   Hsu, Shih Lan ^a   Tzeng, Yew Min ^b  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTCIN A; ANTCIN C; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BONGKREKIC ACID; CASPASE 2; CASPASE 3; CASPASE 9; COFILIN; CYCLOSPORIN A; CYTOCHROME C; DNA; METHYL ANTCINATE A; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTRODIA CAMPHORATA; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HEP3B; CELL STRAIN HEPG2; CELL STRAIN HUH7; CONTROLLED STUDY; DNA FRAGMENTATION; HUMAN; HUMAN CELL; IC 50; LIVER CANCER; LIVER CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR MECHANICS; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTRODIA; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 2; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; COFILIN 1; CYTOCHROMES C; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NADPH OXIDASE; OXIDANTS; PROTO-ONCOGENE PROTEINS; RATS; REACTIVE OXYGEN SPECIES; TRITERPENES;

RATTUS; TAIWANOFUNGUS CAMPHORATUS;

EID: 77955369919     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100116a     Document Type: Article

References (41)

1. Chang, T. T. and Chou, W. W. (1995) Antrodia cinnamomea sp. nov. on Cinnamomum kanehirai in Taiwan Mycol. Res. 99, 756-758
2. Geethangili, M. and Tzeng, Y. M. (2009) Review of pharmacological effects of Antrodia camphorata and its bioactive compounds. Evid. Based Complement. Alternat. Med. doi: 10.1093/ecam/nep108
3. Peng, C. C., Chen, K. C., Peng, R. Y., Su, C. H., and Hsieh-Li, H. M. (2006) Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts Cancer Lett. 243, 109-119
4. Song, T. Y., Hsu, S. L., Yeh, C. T., and Yen, G. C. (2005) Mycelia from Antrodia camphorata in submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway J. Agric. Food Chem. 53, 5559-5564
5. Hsu, Y. L., Kuo, Y. C., Kuo, P. L., Ng, L. T., Kuo, Y. H., and Lin, C. C. (2005) Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines Cancer Lett. 221, 77-89
6. Kuo, P. L., Hsu, Y. L., Cho, C. Y., Ng, L. T., Kuo, Y. H., and Lin, C. C. (2006) Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep3B cells Food Chem. Toxicol. 44, 1316-1326
7. Yang, H. L., Chen, C. S., Chang, W. H., Lu, F. J., Lai, Y. C., Chen, C. C., Hseu, T. H., Kuo, C. T., and Hseu, Y. C. (2006) Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata Cancer Lett. 231, 215-227
8. Hseu, Y. C., Chen, S. C., Chen, H. C., Liao, J. W., and Yang, H. L. (2008) Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo Food Chem. Toxicol. 46, 2680-2688
9. Lu, M. C., Du, Y. C., Chuu, J. J., Hwang, S. L., Hsieh, P. C., Hung, C. S., Chang, F. R., and Wu, Y. C. (2009) Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A Arch. Toxicol. 83, 121-129
10. Rao, Y. K., Fang, S. H., and Tzeng, Y. M. (2007) Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts J. Ethnopharmacol. 114, 78-85
11. Yeh, C. T., Rao, Y. K., Yao, C. J., Yeh, C. F., Li, C. H., Chuang, S. E., Luong, J. H., Lai, G. M., and Tzeng, Y. M. (2009) Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells Cancer Lett. 285, 73-79
12. Geethangili, M., Fang, S. H., Lai, C. H., Rao, Y. K., and Tzeng, Y. M. (2010) Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori- associated gastric inflammation Food Chem. 119, 149-153
13. Male, K. B., Rao, Y. K., Tzeng, Y. M., Montes, J., Kamen, A., and Luong, J. H. (2008) Probing inhibitory effects of Antrodia camphorata isolates using insect cell-based impedance spectroscopy: Inhibition vs chemical structure Chem. Res. Toxicol. 21, 2127-2133
14. Deng, J. Y., Chen, S. J., Jow, G. M., Hsueh, C. W., and Jeng, C. J. (2009) Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas Chem. Res. Toxicol. 22, 1817-1826
15. Cherng, I. H., Chiang, H. C., Cheng, M. C., and Wang, Y. (1995) Three new triterpenoids from Antrodia cinnamomea J. Nat. Prod. 58, 365-371
16. Wu, D. P. and Chiang, C. H. (1995) Constituents of Antrodia cinnamomea J. Chin. Chem. Soc. 42, 797-800
17. Shen, Y. C., Chen, C. F., Wang, Y. H., Chang, T. T., and Chou, C. J. (2003) Evaluation of the immuno-modulating activity of some active principles isolated from the fruiting bodies of Antrodia camphorata Chin. Pharm. J. 55, 313-318
18. Chen, J. J., Lin, W. J., Liao, C. H., and Shieh, P. C. (2007) Anti-inflammatory benzenoids from Antrodia camphorata J. Nat. Prod. 70, 989-992
19. Kimura, A., Toyoki, Y., Hakamada, K., Yoshihara, S., and Sasaki, M. (2008) Characterization of heparan sulfate on hepatocytes in regenerating rat liver J. Hepatobiliary Pancreatic Surg. 15, 608-614
20. Sun, Y., St. Clair, D. K., Xu, Y., Crooks, P. A., and St. Clair, W. H. (2010) A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells Cancer Res. 70, 2880-2890
21. Ow, Y. P., Green, D. R., Hao, Z., and Mak, T. W. (2008) Cytochrome c: Functions beyond respiration Nat. Rev. Mol. Cell Biol. 9, 532-542
22. Hail, N., Jr. and Lotan, R. (2009) Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state Mol. Nutr. Food Res. 53, 49-67
23. Kumar, B., Koul, S., Khandrika, L., Meacham, R. B., and Koul, H. K. (2008) Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype Cancer Res. 68, 1777-1785
24. Klamt, F., Zdanov, S., Levine, R. L., Pariser, A., Zhang, Y., Zhang, B., Yu, L. R., Veenstra, T. D., and Shacter, E. (2009) Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin Nat. Cell Biol. 11, 1241-1246
25. Lodato, F., Mazzella, G., Festi, D., Azzaroli, F., Colecchia, A., and Roda, E. (2006) Hepatocellular carcinoma prevention: A worldwide emergence between the opulence of developed countries and the economic constraints of developing nations World J. Gastroenterol. 12, 7239-7249
26. Schwartz, M., Roayaie, S., and Konstadoulakis, M. (2007) Strategies for the management of hepatocellular carcinoma Nat. Clin. Pract. Oncol. 4, 424-432
27. Banerjee, S., Wang, Z., Mohammad, M., Sarkar, F. H., and Mohammad, R. M. (2008) Efficacy of selected natural products as therapeutic agents against cancer J. Nat. Prod. 71, 492-496
28. Kinghorn, A. D., Chin, Y. W., and Swanson, S. M. (2009) Discovery of natural product anticancer agents from biodiverse organisms Curr. Opin. Drug Discovery Dev. 12, 189-196
29. Kurokawa, M. and Kornbluth, S. (2009) Caspases and kinases in a death grip Cell 138, 838-854
30. Ghavami, S., Hashemi, M., Ande, S. R., Yeganeh, B., Xiao, W., Eshraghi, M., Bus, C. J., Kadkhoda, K., Wiechec, E., Halayko, A. J., and Los, M. (2009) Apoptosis and cancer: mutations within caspase genes J. Med. Genet. 46, 497-510
31. Balaban, R. S. (2006) Modeling mitochondrial function Am. J. Physiol.: Cell Physiol. 291, c1107-c1113
32. Gross, A., McDonnell, J. M., and Korsmeyer, S. J. (1999) BCL-2 family members and the mitochondria in apoptosis Genes Dev. 13, 1899-1911
33. Wang, X. (2001) The expanding role of mitochondria in apoptosis Genes Dev. 15, 2922-2933
34. Shimizu, S., Narita, M., and Tsujimoto, Y. (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC Nature 399, 483-487
35. Zha, H. and Reed, J. C. (1997) Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells J. Biol. Chem. 272, 31482-31488
36. Visconti, R. and Grieco, D. (2009) New insights on oxidative stress in cancer Curr. Opin. Drug. Discovery Dev. 12, 240-245
37. Trachootham, D., Alexandre, J., and Huang, P. (2009) Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach Nat. Rev. Drug Discovery 8, 579-591
38. Bamburg, J. R. and Wiggan, O. P. (2002) ADF/cofilin and actin dynamics in disease Trends Cell Biol. 12, 598-605
39. Chua, B. T., Volbracht, C., Tan, K. O., Li, R., Yu, V. C., and Li, P. (2003) Mitochondrial translocation of cofilin is an early step in apoptosis induction Nat. Cell Biol. 5, 1083-1089
40. Zhu, B., Fukada, K., Zhu, H., and Kyprianou, N. (2006) Prohibitin and cofilin are intracellular effectors of transforming growth factor-Î2 signaling in human prostate cancer cells Cancer Res. 66, 8640-8647
41. Mannherz, H. G., Gonsior, S. M., Gremm, D., Wu, X., Pope, B. J., and Weeds, A. G. (2005) Activated cofilin colocalises with Arp2/3 complex in apoptotic blebs during programmed cell death Eur. J. Cell Biol. 84, 503-515