Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Wei, Shuo ^a,d   Chu, Po Chen ^a   Chuang, Hsiao Ching ^a   Hung, Wen Chun ^b   Kulp, Samuel K ^a   Chen, Ching Shih ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CG 12; COP9 SIGNALOSOME; CULLIN 1; CYCLIN DEPENDENT KINASE 2; DEOXYGLUCOSE; ENERGY RESTRICTION MIMETIC AGENT; F BOX PROTEIN; PROLINE; PROTEIN CSN5; S PHASE KINASE ASSOCIATED PROTEIN 2; SIRTUIN 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL FUNCTION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; FEEDBACK SYSTEM; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MOLECULAR RECOGNITION; NEDDYLATION; PROSTATE CANCER; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SKP2 GENE; UPREGULATION;

BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; ENERGY METABOLISM; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PEPTIDE HYDROLASES; PROSTATIC NEOPLASMS; S-PHASE KINASE-ASSOCIATED PROTEINS; SIRTUIN 1;

EID: 84867432711     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047298     Document Type: Article

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