The anesthetic steroid (+)-3α-hydroxy-5α-androstane-17β-carbonitrile blocks N-, Q-, and R-type, but Not L- and P-Type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat

Molecular Pharmacology

Volumn 54, Issue 3, 1998, Pages 559-568

  Nakashima, Yasunori M ^a,b   Todorovic, Slobodan M ^a   Covey, Douglas F ^a   Lingle, Christopher J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA ANDROSTANE 17BETA CARBONITRILE; ANESTHETIC AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; NIFEDIPINE; STEROID; UNCLASSIFIED DRUG; 3 HYDROXY 5 ANDROSTANE 17 CARBONITRILE; 3-HYDROXY-5-ANDROSTANE-17-CARBONITRILE; ANDROSTANE DERIVATIVE; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; NITRILE; OMEGA CONOTOXIN; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIC; OMEGA-CONOTOXIN-MVIIC; PEPTIDE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; DRUG MECHANISM; DRUG SELECTIVITY; HIPPOCAMPUS; MEMBRANE CURRENT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION; ANIMAL; CELL CULTURE; CLASSIFICATION; DRUG EFFECT; MALE; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ANDROSTANOLS; ANESTHETICS; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELLS, CULTURED; GANGLIA, SPINAL; GTP-BINDING PROTEINS; HIPPOCAMPUS; MALE; NEURONS; NITRILES; OMEGA-CONOTOXIN GVIA; OMEGA-CONOTOXINS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031595681     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.3.559     Document Type: Article

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