NAD(P)H Cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 34992-35003

  Mukherjee, Supratim ^a   Santara, Sumit Sen ^a   Das, Shantanabha ^a   Bose, Moumita ^a   Roy, Jayasree ^a   Adak, Subrata ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ATP SYNTHESIS; CELL LINES; CYTOCHROME B; DEAD CELLS; DESATURASE; EUKARYOTIC ORGANISMS; FERROUS STATE; FLOW-CYTOMETRIC ANALYSIS; FREE FATTY ACID; GENE REPLACEMENT; KNOCK OUTS; KNOCKOUT MUTANT; LEISHMANIA; LEISHMANIA MAJOR; LEISHMANIA SPECIES; LIPID METABOLISMS; MITOCHONDRIAL MEMBRANE POTENTIAL; MRNA EXPRESSION; NAD(P)H; OXIDOREDUCTASES; REAL-TIME PCR; SPECTRAL STUDIES; STEADY-STATE CATALYSIS; SUPER OXIDE DISMUTASE; WILD TYPES;

CELL DEATH; CLONING; ENZYME ACTIVITY; GENES; NANOCAPSULES; OXIDATIVE STRESS; OXYGEN; SPECTROSCOPIC ANALYSIS;

CELL CULTURE;

ACYL COENZYME A DESATURASE; ADENOSINE TRIPHOSPHATE; BOVINE SERUM ALBUMIN; CYTOCHROME B5 REDUCTASE; DESATURASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; LINOLEIC ACID; LINOLENIC ACID; MESSENGER RNA; OXYGEN; OXYGENASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL LINE; ENZYME DEFICIENCY; FATTY ACID SYNTHESIS; FLOW CYTOMETRY; GENE INACTIVATION; GENE OVEREXPRESSION; LEISHMANIA MAJOR; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; APOPTOSIS; CYTOCHROME-B(5) REDUCTASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; LEISHMANIA MAJOR; LINOLEIC ACID; MICE; OXIDATIVE STRESS; OXYGEN; OXYGEN CONSUMPTION; PROTOZOAN PROTEINS; RNA, MESSENGER; RNA, PROTOZOAN;

EID: 84867418369     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.389338     Document Type: Article

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