Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Alloatti, Andrés ^a   Gupta, Shreedhara ^b   Gualdrón López, Melisa ^b   Igoillo Esteve, Mariana ^b   Nguewa, Paul A ^b   Deumer, Gladys ^c   Wallemacq, Pierre ^c   Altabe, Silvia G ^a   Michels, Paul A M ^b   Uttaro, Antonio D ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b DE DUVE INSTITUTE   (Belgium)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

LINOLEIC ACID; OLEIC ACID; OLEIC ACID DESATURASE; OXYGENASE; OXYGENASE INHIBITOR; STEARIC ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; ACYL COENZYME A DESATURASE; ENZYME INHIBITOR; FATTY ACID; HEME; OXIDOREDUCTASE; PHOSPHATIDYLCHOLINE DESATURASE; STEARIC ACID DERIVATIVE;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ARTICLE; CELL GROWTH; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC ANALYSIS; GROWTH INHIBITION; MAMMAL CELL; MEMBRANE FLUIDITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; RNA INTERFERENCE; TRYPANOSOMA; TRYPANOSOMA BRUCEI; ANIMAL; CHEMISTRY; DRUG DESIGN; GENETICS; HUMAN; METABOLISM; METHODOLOGY;

HEXAPODA; MAMMALIA; TRYPANOSOMA BRUCEI;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; FATTY ACID DESATURASES; FATTY ACIDS; HEME; HUMANS; LINOLEIC ACID; OLEIC ACID; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PHENOTYPE; RNA INTERFERENCE; STEARATES; STEAROYL-COA DESATURASE; TRYPANOSOMA BRUCEI BRUCEI;

EID: 78650104480     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014239     Document Type: Article

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