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Volumn 76, Issue , 2011, Pages 129-137

Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; CHOLESTEROL; CHOLESTEROL ESTER; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; OXYSTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; REELIN; SERINE PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN RECEPTOR; APOLIPOPROTEIN E; PROTEIN; STEROL; UBIQUITIN PROTEIN LIGASE E3; VLDLR PROTEIN;

EID: 84867405858     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2011.76.010702     Document Type: Article
Times cited : (30)

References (79)
  • 4
    • 47949094965 scopus 로고    scopus 로고
    • Integration of metabolism and inflammation by lipid-activated nuclear receptors
    • Bensinger SJ, Tontonoz P. 2008. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454: 470-477.
    • (2008) Nature , vol.454 , pp. 470-477
    • Bensinger, S.J.1    Tontonoz, P.2
  • 5
    • 77951063806 scopus 로고    scopus 로고
    • Non-redundant roles for LXRa and LXRb in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
    • Bischoff ED, Daige CL, Petrowski M, Dedman H, Pattison J, Juliano J, Li AC, Schulman IG. 2010. Non-redundant roles for LXRa and LXRb in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res 51: 900-906.
    • (2010) J Lipid Res , vol.51 , pp. 900-906
    • Bischoff, E.D.1    Daige, C.L.2    Petrowski, M.3    Dedman, H.4    Pattison, J.5    Juliano, J.6    Li, A.C.7    Schulman, I.G.8
  • 9
    • 48249115641 scopus 로고    scopus 로고
    • Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
    • Cameron J, Holla OL, Berge KE, Kulseth MA, Ranheim T, Leren TP, Laerdahl JK. 2008. Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion. Febs J 275: 4121-4133.
    • (2008) Febs J , vol.275 , pp. 4121-4133
    • Cameron, J.1    Holla, O.L.2    Berge, K.E.3    Kulseth, M.A.4    Ranheim, T.5    Leren, T.P.6    Laerdahl, J.K.7
  • 10
    • 8444233254 scopus 로고    scopus 로고
    • Nuclear receptors in macrophage biology: At the crossroads of lipid metabolism and inflammation
    • Castrillo A, Tontonoz P. 2004. Nuclear receptors in macrophage biology: At the crossroads of lipid metabolism and inflammation. Annu Rev Cell Dev Biol 20: 455-480.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 455-480
    • Castrillo, A.1    Tontonoz, P.2
  • 12
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. 2006. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. New Engl J Med 354: 1264-1272.
    • (2006) New Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 13
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet P, Luo Y, Wang N, Tall AR. 2000. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 275: 28240-28245.
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 14
    • 1842607157 scopus 로고    scopus 로고
    • Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches
    • Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R. 2004. Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. Structure 12: 633-644.
    • (2004) Structure , vol.12 , pp. 633-644
    • Dominguez, C.1    Bonvin, A.M.2    Winkler, G.S.3    van Schaik, F.M.4    Timmers, H.T.5    Boelens, R.6
  • 15
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans RM. 1988. The steroid and thyroid hormone receptor superfamily. Science 240: 889-895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 16
    • 0034650893 scopus 로고    scopus 로고
    • The coregulator exchange in transcriptional functions of nuclear receptors
    • Glass CK, Rosenfeld MG. 2000. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14: 121-141.
    • (2000) Genes Dev , vol.14 , pp. 121-141
    • Glass, C.K.1    Rosenfeld, M.G.2
  • 17
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS. 1990. Regulation of the mevalonate pathway. Nature 343: 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 19
    • 48349092091 scopus 로고    scopus 로고
    • Plasma PCSK9 preferentially reduces liver LDL receptors in mice
    • Grefhorst A, McNutt MC, Lagace TA, Horton JD. 2008. Plasma PCSK9 preferentially reduces liver LDL receptors in mice. J Lipid Res 49: 1303-1311.
    • (2008) J Lipid Res , vol.49 , pp. 1303-1311
    • Grefhorst, A.1    McNutt, M.C.2    Lagace, T.A.3    Horton, J.D.4
  • 21
    • 0034283003 scopus 로고    scopus 로고
    • Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
    • Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T. 2000. Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J 19: 4449-4462.
    • (2000) EMBO J , vol.19 , pp. 4449-4462
    • Hamada, K.1    Shimizu, T.2    Matsui, T.3    Tsukita, S.4    Hakoshima, T.5
  • 22
    • 0033213319 scopus 로고    scopus 로고
    • Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    • Hiesberger T, Trommsdorff M, HowellBW, Goffinet A, Mumby MC, Cooper JA, Herz J. 1999. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 24: 481-489.
    • (1999) Neuron , vol.24 , pp. 481-489
    • Hiesberger, T.1    Trommsdorff, M.2    Howell, B.W.3    Goffinet, A.4    Mumby, M.C.5    Cooper, J.A.6    Herz, J.7
  • 23
    • 56249140398 scopus 로고    scopus 로고
    • Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors
    • Hong C, Tontonoz P. 2008. Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Curr Opin Genet Dev 18: 461-467.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 461-467
    • Hong, C.1    Tontonoz, P.2
  • 25
    • 79953177493 scopus 로고    scopus 로고
    • Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: Identification of ARL7 as a direct target
    • Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. 2011. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: Identification of ARL7 as a direct target. J Lipid Res 52: 531-539.
    • (2011) J Lipid Res , vol.52 , pp. 531-539
    • Hong, C.1    Walczak, R.2    Dhamko, H.3    Bradley, M.N.4    Marathe, C.5    Boyadjian, R.6    Salazar, J.V.7    Tontonoz, P.8
  • 26
    • 33846679386 scopus 로고    scopus 로고
    • Molecular biology of PCSK9: Its role in LDL metabolism
    • Horton JD, Cohen JC, Hobbs HH. 2007. Molecular biology of PCSK9: Its role in LDL metabolism. Trends Biochem Sci 32: 71-77.
    • (2007) Trends Biochem Sci , vol.32 , pp. 71-77
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 27
    • 1642465503 scopus 로고    scopus 로고
    • Liver X receptors are regulators of adipocyte gene expression but not differentiation: Identification of apoD as a direct target
    • Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P. 2004. Liver X receptors are regulators of adipocyte gene expression but not differentiation: Identification of apoD as a direct target. J Lipid Res 45: 616-625.
    • (2004) J Lipid Res , vol.45 , pp. 616-625
    • Hummasti, S.1    Laffitte, B.A.2    Watson, M.A.3    Galardi, C.4    Chao, L.C.5    Ramamurthy, L.6    Moore, J.T.7    Tontonoz, P.8
  • 30
    • 0034266806 scopus 로고    scopus 로고
    • RING finger proteins: Mediators of ubiquitin ligase activity
    • Joazeiro CA, Weissman AM. 2000. RING finger proteins: Mediators of ubiquitin ligase activity. Cell 102: 549-552.
    • (2000) Cell , vol.102 , pp. 549-552
    • Joazeiro, C.A.1    Weissman, A.M.2
  • 31
    • 0037385266 scopus 로고    scopus 로고
    • LXRs: New therapeutic targets in atherosclerosis?
    • Joseph SB, Tontonoz P. 2003. LXRs: New therapeutic targets in atherosclerosis? Curr Opin Pharmacol 3: 192-197.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 192-197
    • Joseph, S.B.1    Tontonoz, P.2
  • 33
    • 0347034082 scopus 로고    scopus 로고
    • Characterization of the human ABCG1 gene: Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
    • Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA. 2001. Characterization of the human ABCG1 gene: Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem 276: 39438-39447.
    • (2001) J Biol Chem , vol.276 , pp. 39438-39447
    • Kennedy, M.A.1    Venkateswaran, A.2    Tarr, P.T.3    Xenarios, I.4    Kudoh, J.5    Shimizu, N.6    Edwards, P.A.7
  • 42
    • 21844467979 scopus 로고    scopus 로고
    • New insights into the regulation of HDL metabolism and reverse cholesterol transport
    • Lewis GF, Rader DJ. 2005. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circul Res 96: 1221-1232.
    • (2005) Circul Res , vol.96 , pp. 1221-1232
    • Lewis, G.F.1    Rader, D.J.2
  • 44
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, et al. 2009. Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119: 480-486.
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    De Simone, G.4    Ferguson, T.B.5    Flegal, K.6    Ford, E.7    Furie, K.8    Go, A.9    Greenlund, K.10
  • 45
    • 40949136906 scopus 로고    scopus 로고
    • PCSK9: An enigmatic protease
    • Lopez D. 2008. PCSK9: An enigmatic protease. Biochim Biophys Acta 1781: 184-191.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 184-191
    • Lopez, D.1
  • 47
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf DJ, Evans RM. 1995. The RXR heterodimers and orphan receptors. Cell 83: 841-850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 48
    • 16644395324 scopus 로고    scopus 로고
    • Cholesterolindependent effects of statins and new therapeutic targets: Ischemic stroke and dementia
    • Miida T, Hirayama S, Nakamura Y. 2004. Cholesterolindependent effects of statins and new therapeutic targets: Ischemic stroke and dementia. J Atheroscler Thromb 11: 253-264.
    • (2004) J Atheroscler Thromb , vol.11 , pp. 253-264
    • Miida, T.1    Hirayama, S.2    Nakamura, Y.3
  • 50
    • 0034724536 scopus 로고    scopus 로고
    • Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
    • Pearson MA, Reczek D, Bretscher A, Karplus PA. 2000. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 101: 259-270.
    • (2000) Cell , vol.101 , pp. 259-270
    • Pearson, M.A.1    Reczek, D.2    Bretscher, A.3    Karplus, P.A.4
  • 53
    • 38349117118 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
    • Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG. 2008. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem 283: 2363-2372.
    • (2008) J Biol Chem , vol.283 , pp. 2363-2372
    • Poirier, S.1    Mayer, G.2    Benjannet, S.3    Bergeron, E.4    Marcinkiewicz, J.5    Nassoury, N.6    Mayer, H.7    Nimpf, J.8    Prat, A.9    Seidah, N.G.10
  • 54
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • Repa JJ, Mangelsdorf DJ. 2000. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Ann Rev Cell Dev Biol 16: 459-481.
    • (2000) Ann Rev Cell Dev Biol , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 55
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: Potential new players in atherosclerosis
    • Repa JJ, Mangelsdorf DJ. 2002. The liver X receptor gene team: Potential new players in atherosclerosis. Nat Med 8: 1243-1248.
    • (2002) Nat Med , vol.8 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 58
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors a and b
    • Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. 2002. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors a and b. J Biol Chem 277: 18793-18800.
    • (2002) J Biol Chem , vol.277 , pp. 18793-18800
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3    Richardson, J.A.4    Hobbs, H.5    Mangelsdorf, D.J.6
  • 61
    • 25444529284 scopus 로고    scopus 로고
    • The human ABCG1 gene: Identification of LXR response elements that modulate expression in macrophages and liver
    • Sabol SL, Brewer HB Jr, Santamarina-Fojo S. 2005. The human ABCG1 gene: Identification of LXR response elements that modulate expression in macrophages and liver. J Lipid Res 46: 2151-2167.
    • (2005) J Lipid Res , vol.46 , pp. 2151-2167
    • Sabol, S.L.1    Brewer Jr., H.B.2    Santamarina-Fojo, S.3
  • 62
    • 0034637128 scopus 로고    scopus 로고
    • ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR
    • Schwartz K, Lawn RM, Wade DP. 2000. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. Biochem Biophys Res Commun 274: 794-802.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 794-802
    • Schwartz, K.1    Lawn, R.M.2    Wade, D.P.3
  • 63
    • 79955378862 scopus 로고    scopus 로고
    • Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
    • Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, et al. 2011. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol 31: 1885-1893.
    • (2011) Mol Cell Biol , vol.31 , pp. 1885-1893
    • Scotti, E.1    Hong, C.2    Yoshinaga, Y.3    Tu, Y.4    Hu, Y.5    Zelcer, N.6    Boyadjian, R.7    de Jong, P.J.8    Young, S.G.9    Fong, L.G.10
  • 65
    • 67649834099 scopus 로고    scopus 로고
    • Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels
    • Steinberg D, Witztum JL. 2009. Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels. Proc Natl Acad Sci 106: 9546-9547.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 9546-9547
    • Steinberg, D.1    Witztum, J.L.2
  • 67
    • 0037503924 scopus 로고    scopus 로고
    • Liver X receptor signaling pathways in cardiovascular disease
    • Tontonoz P, Mangelsdorf DJ. 2003. Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17: 985-993.
    • (2003) Mol Endocrinol , vol.17 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 70
    • 0034640288 scopus 로고    scopus 로고
    • Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages A transcriptional role for specific oxysterols
    • Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. 2000b. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem 275: 14700-14707.
    • (2000) J Biol Chem , vol.275 , pp. 14700-14707
    • Venkateswaran, A.1    Repa, J.J.2    Lobaccaro, J.M.3    Bronson, A.4    Mangelsdorf, D.J.5    Edwards, P.A.6
  • 71
    • 3042798281 scopus 로고    scopus 로고
    • ATPbinding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
    • Wang N, Lan D, Chen W, Matsuura F, Tall AR. 2004. ATPbinding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci 101: 9774-9779.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 9774-9779
    • Wang, N.1    Lan, D.2    Chen, W.3    Matsuura, F.4    Tall, A.R.5
  • 73
    • 0031042762 scopus 로고    scopus 로고
    • Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR
    • Willy PJ, Mangelsdorf DJ. 1997. Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR. Genes Dev 11: 289-298.
    • (1997) Genes Dev , vol.11 , pp. 289-298
    • Willy, P.J.1    Mangelsdorf, D.J.2
  • 75
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer N, Tontonoz P. 2006. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116: 607-614.
    • (2006) J Clin Invest , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 77
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    • Zelcer N, Hong C, Boyadjian R, Tontonoz P. 2009. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325: 100-104.
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3    Tontonoz, P.4
  • 78
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
    • ZhangDW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH. 2007. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem 282: 18602-18612.
    • (2007) J Biol Chem , vol.282 , pp. 18602-18612
    • ZhangD, W.1    Lagace, T.A.2    Garuti, R.3    Zhao, Z.4    McDonald, M.5    Horton, J.D.6    Cohen, J.C.7    Hobbs, H.H.8


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