Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability

Biotechnology Progress

Volumn 28, Issue 5, 2012, Pages 1138-1151

  Kondragunta, Bhargavi ^a,b,c   Joshi, Bharat H ^b   Han, Jing ^b   Brorson, Kurt A ^c   Puri, Raj K ^b   Moreira, Antonio R ^a   Rao, Govind ^a  

^a University of Marylandw Baltimore County   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Minibioreactors; Scale down; Sentinel genes; Time course

Indexed keywords

CELLULAR FUNCTION; DIFFERENTIAL EXPRESSIONS; DNA DAMAGE RESPONSE; DNA MICRO-ARRAY; ENVIRONMENT-SENSITIVE; GENE ANALYSIS; GENE FINDING; GENOMIC PROFILES; HIGH-THROUGHPUT; MINIBIOREACTORS; OXIDATIVE STRESS RESPONSE; OXYGEN TRANSFER RATE; Q-RT-PCR; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; SCALE-DOWN; TIME-COURSE;

BIOASSAY; BIOCHIPS; BIOCONVERSION; BIOREACTORS; CELL CULTURE; CELL GROWTH; GROWTH KINETICS; MIXING; POLYMERASE CHAIN REACTION;

GENE EXPRESSION;

OXYGEN; PROTEIN; TRANSCRIPTOME;

ANIMAL; ARTICLE; BIOREACTOR; CELLS; CULTURE TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; INSTRUMENTATION; METABOLISM; MOUSE; TUMOR CELL LINE;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELLS; GENE EXPRESSION REGULATION; MICE; OXYGEN; PROTEINS; TRANSCRIPTOME;

EID: 84867385428     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1606     Document Type: Article

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