Glutamine randomized studies in early life: The unsolved riddle of experimental and clinical studies

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Briassouli, Efrossini ^a   Briassoulis, George ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUTAMINE; HEAT SHOCK PROTEIN; ORNITHINE; SELENIUM;

ANTIOXIDANT ACTIVITY; CRITICALLY ILL PATIENT; CYTOKINE RELEASE; DIETARY INTAKE; DRUG DOSE INCREASE; ENTERIC FEEDING; EXTREMELY LOW BIRTH WEIGHT; HUMAN; IMMUNOPATHOLOGY; INFECTION CONTROL; INFLAMMATION; MORBIDITY; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEPSIS; SIGNAL TRANSDUCTION; ANIMAL; CRITICAL ILLNESS; DIET SUPPLEMENTATION; NEWBORN;

ANIMALS; ANIMALS, NEWBORN; CRITICAL ILLNESS; DIETARY SUPPLEMENTS; GLUTAMINE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84867365243     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/749189     Document Type: Review

References (120)

1. Fläring U. B., Rooyackers O. E., Wernerman J., Hammarqvist F., Glutamine attenuates post-traumatic glutathione depletion in human muscle. Clinical Science 2003 104 3 275 282 2-s2.0-17944401183 10.1042/CS20020198
2. Wischmeyer P. E., Can glutamine turn off the motor that drives systemic inflammation? Critical Care Medicine 2005 33 5 1175 1178 2-s2.0-18344365310 10.1097/01.CCM.0000162686.28604.81
3. Gamrin L., Essén P., Forsberg A. M., Hultman E., Wernerman J., A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytes. Critical Care Medicine 1996 24 4 575 583 2-s2.0-0029863077 10.1097/00003246-199604000-00005
4. Labow B. I., Souba W. W., Abcouwer S. F., Mechanisms governing the expression of the enzymes of glutamine metabolism-glutaminase and glutamine synthetase. Journal of Nutrition 2001 131 9 2467S 2474S 2-s2.0-0034847451
5. Parry-Billings M., Evans J., Calder P. C., Newsholme E. A., Does glutamine contribute to immunosuppression after major burns? The Lancet 1990 336 8714 523 525 2-s2.0-0025150173 10.1016/0140-6736(90)92083-T
6. Wischmeyer P. E., Glutamine: role in critical illness and ongoing clinical trials. Current Opinion in Gastroenterology 2008 24 2 190 197 2-s2.0-40049090376 10.1097/MOG.0b013e3282f4db94
7. Huang Y., Shao X. M., Neu J., Immunonutrients and neonates. European Journal of Pediatrics 2003 162 3 122 128 2-s2.0-0037341928
8. Pohlandt F., Plasma amino acid concentrations in newborn infants breast-fed ad libitum. Journal of Pediatrics 1978 92 4 614 616 2-s2.0-0017802404
9. Becker R. M., Wu G., Galanko J. A., Chen W., Maynor A. R., Bose C. L., Rhoads J. M., Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. Journal of Pediatrics 2000 137 6 785 793 2-s2.0-0033636420 10.1067/mpd.2000.109145
10. Bernt K. M., Walker W. A., Human milk as a carrier of biochemical messages. Acta Paediatrica, International Journal of Paediatrics, Supplement 1999 88 430 27 41 2-s2.0-0032829889
11. Verbruggen S., Sy J., Arrivillaga A., Joosten K., Van Goudoever J., Castillo L., Parenteral amino acid intakes in critically Ill children: a matter of convenience. Journal of Parenteral and Enteral Nutrition 2010 34 3 329 340 2-s2.0-77953665567 10.1177/0148607109347897
12. Newsholme E. A., Crabtree B., Ardawi M. S. M., Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Quarterly Journal of Experimental Physiology 1985 70 4 473 489 2-s2.0-0022196860
13. Windmueller H. G., Spaeth A. E., Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. Quantitative importance of glutamine, glutamate, and aspartate. Journal of Biological Chemistry 1980 255 1 107 112 2-s2.0-0018898289
14. Rapoport S., Rost J., Schultze M., Glutamine and glutamate as respiratory substrates of rabbit reticulocytes. European Journal of Biochemistry 1971 23 1 166 170 2-s2.0-0015220224
15. Darmaun D., Matthews D. E., Desjeux J. F., Bier D. M., Glutamine and glutamate nitrogen exchangeable pools in cultured fibroblasts: a stable isotope study. Journal of Cellular Physiology 1988 134 1 143 148 2-s2.0-0023871701
16. Ligthart-Melis G. C., Van De Poll M. C. G., Boelens P. G., Dejong C. H. C., Deutz N. E. P., Van Leeuwen P. A. M., Glutamine is an important precursor for de novo synthesis of arginine in humans. American Journal of Clinical Nutrition 2008 87 5 1282 1289 2-s2.0-43549122835
17. Neu J., Glutamine in the fetus and critically III low birth weight neonate: metabolism and mechanism of action. Journal of Nutrition 2001 131 9 2585S 2589S 2-s2.0-0034853815
18. Wilmore D. W., The effect of glutamine supplementation in patients following elective surgery and accidental injury. Journal of Nutrition 2001 131 9 2543S 2549S 2-s2.0-0034842396
19. Nurjhan N., Bucci A., Perriello G., Stumvoll M., Dailey G., Bier D. M., Toft I., Jenssen T. G., Gerich J. E., Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. Journal of Clinical Investigation 1995 95 1 272 277 2-s2.0-0028798885
20. Mithieux G., New data and concepts on glutamine and glucose metabolism in the gut. Current Opinion in Clinical Nutrition and Metabolic Care 2001 4 4 267 271 2-s2.0-0035744597 10.1097/00075197-200107000-00004
21. Lacey J. M., Wilmore D. W., Is glutamine a conditionally essential amino acid? Nutrition Reviews 1990 48 8 297 309 2-s2.0-0025475371
22. Welbourne T. C., Childress D., Givens G., Renal regulation of interorgan glutamine flow in metabolic acidosis. American Journal of Physiology 1986 251 5 R859 R866 2-s2.0-0023001648
23. Neu J., DeMarco V., Li N., Glutamine: clinical applications and mechanisms of action. Current Opinion in Clinical Nutrition & Metabolic Care 2002 5 1 69 75 10.1097/00075197-200201000-00013
24. Waitzberg D. L., Saito H., Plank L. D., Jamieson G. G., Jagannath P., Hwang T. L., Mijares J. M., Bihari D., Postsurgical infections are reduced with specialized nutrition support. World Journal of Surgery 2006 30 8 1592 1604 2-s2.0-33748861797 10.1007/s00268-005-0657-x
25. Angus D. C., Linde-Zwirble W. T., Lidicker J., Clermont G., Carcillo J., Pinsky M. R., Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine 2001 29 7 1303 1310 2-s2.0-0034958947
26. Carcillo J. A., Dean J. M., Holubkov R., The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. Pediatric Critical Care Medicine 2012 13 2 165 173 10.1097/PCC. 0b013e31823896ae
27. Dholakia S., Inwald D., Betts H., Nadel S., Endotoxemia in pediatric critical illnessa pilot study. Critical Care 2011 15 3, article R141 2-s2.0-79958049172 10.1186/cc10264
28. Larsen G. Y., Mecham N., Greenberg R., An emergency department septic shock protocol and care guideline for children initiated at triage. Pediatrics 2011 127 6 e1585 e1592 2-s2.0-79957903859 10.1542/peds.2010-3513
29. Wong H. R., Cvijanovich N. Z., Allen G. L., Validation of a gene expression-based subclassification strategy for pediatric septic shock. Critical Care Medicine 2011 39 11 2511 2517 10.1097/CCM.0b013e3182257675
30. Dahmer M. K., Randolph A., Vitali S., Quasney M. W., Genetic polymorphisms in sepsis. Pediatric Critical Care Medicine 2005 6 supplement 3 S61 S73 2-s2.0-19444378437 10.1097/01.PCC.0000161970.44470.C7
31. Heyland D. K., Novak F., Drover J. W., Jain M., Su X., Suchner U., Should immunonutrition become routine in critically III patients? A systematic review of the evidence. Journal of the American Medical Association 2001 286 8 944 953 2-s2.0-0035934054
32. Wischmeyer P. E., Glutamine: mode of action in critical illness. Critical Care Medicine 2007 35 9 S541 S544 2-s2.0-34548159291 10.1097/01.CCM.0000278064. 32780.D3
33. Curi R., Lagranha C. J., Doi S. Q., Sellitti D. F., Procopio J., Pithon-Curi T. C., Corless M., Newsholme P., Molecular mechanisms of glutamine action. Journal of Cellular Physiology 2005 204 2 392 401 2-s2.0-21644477132 10.1002/jcp.20339
34. Babu R., Eaton S., Drake D. P., Spitz L., Pierro A., Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes. Journal of Pediatric Surgery 2001 36 2 282 286 2-s2.0-0035144429 10.1053/jpsu.2001.20690
35. Bongers T., Griffiths R. D., McArdle A., Exogenous glutamine: the clinical evidence. Critical Care Medicine 2007 35 9 S545 S552 2-s2.0-34548161692 10.1097/01.CCM.0000279193.23737.06
36. Li N., Lewis P., Samuelson D., Liboni K., Neu J., Glutamine regulates Caco-2 cell tight junction proteins. American Journal of Physiology 2004 287 3 G726 G733 2-s2.0-4143138617 10.1152/ajpgi.00012.2004
37. Eaton S., Impaired energy metabolism during neonatal sepsis: the effects of glutamine. Proceedings of the Nutrition Society 2003 62 3 745 751 2-s2.0-0141634292 10.1079/PNS2003284
38. Zingarelli B., Sheehan M., Wong H. R., Nuclear factor- κ B as a therapeutic target in critical care medicine. Critical Care Medicine 2003 31 1 S105 S111 2-s2.0-0037247748
39. Singleton K. D., Beckey V. E., Wischmeyer P. E., Glutamine prevents activation of NF- κ B and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis. Shock 2005 24 6 583 589 2-s2.0-33644968172
40. Borges T. J., Wieten L., van Herwijnen M. J., Broere F., van der Zee R., Bonorino C., van Eden W., The anti-inflammatory mechanisms of Hsp70. Frontiers in Immunology 2012 3, article 95
41. Lai Y., Stange C., Wisniewski S. R., Adelson P. D., Janesko-Feldman K. L., Brown D. S., Kochanek P. M., Clark R. S. B., Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury. Developmental Neuroscience 2006 28 4-5 336 341 2-s2.0-33748170719 10.1159/000094159
42. Song M., Pinsky M. R., Kellum J. A., Heat shock factor 1 inhibits nuclear factor- κ B nuclear binding activity during endotoxin tolerance and heat shock. Journal of Critical Care 2008 23 3 406 415 2-s2.0-49749106266 10.1016/j.jcrc.2007.09.007
43. Weiss Y. G., Bromberg Z., Raj N., Raphael J., Goloubinoff P., Ben-Neriah Y., Deutschman C. S., Enhanced heat shock protein 70 expression alters proteasomal degradation of I κ B kinase in experimental acute respiratory distress syndrome. Critical Care Medicine 2007 35 9 2128 2138 2-s2.0-34548292474 10.1097/01.CCM.0000278915.78030.74
44. Wischmeyer P. E., Riehm J., Singleton K. D., Ren H., Musch M. W., Kahana M., Chang E. B., Glutamine attenuates tumor necrosis factor- α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition 2003 19 1 1 6 2-s2.0-0037221363 10.1016/S0899-9007(02)00839-0
45. Coëffier M., Claeyssens S., Hecketsweiler B., Lavoinne A., Ducrotté P., Déchelotte P., Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. American Journal of Physiology 2003 285 2 G266 G273 2-s2.0-0038103004
46. Huang Y. F., Wang Y., Watford M., Glutamine directly downregulates glutamine synthetase protein levels in mouse C2C12 skeletal muscle myotubes. Journal of Nutrition 2007 137 6 1357 1362 2-s2.0-34249812965
47. Singleton K. D., Wischmeyer P. E., Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. American Journal of Physiology 2006 290 5 L956 L961 2-s2.0-33646556466 10.1152/ajplung.00466.2005
48. Oehler R., Roth E., Regulative capacity of glutamine. Current Opinion in Clinical Nutrition and Metabolic Care 2003 6 3 277 282 2-s2.0-0038604051 10.1097/00075197-200305000-00002
49. Gong J., Jing L., Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1. Minerva Anestesiologica 2011 77 5 488 495 2-s2.0-79957650912
50. Singleton K. D., Wischmeyer P. E., Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. Journal of Parenteral and Enteral Nutrition 2008 32 4 371 376 2-s2.0-45749100074 10.1177/0148607108320661
51. Morrison A. L., Dinges M., Singleton K. D., Odoms K., Wong H. R., Wischmeyer P. E., Glutamine's protection against cellular injury is dependent on heat shock factor-1. American Journal of Physiology 2006 290 6 C1625 C1632 2-s2.0-33744822167 10.1152/ajpcell.00635.2005
52. Wischmeyer P. E., Kahana M., Wolfson R., Ren H., Musch M. M., Chang E. B., Glutamine induces heat shock protein and protects against endotoxin shock in the rat. Journal of Applied Physiology 2001 90 6 2403 2410 2-s2.0-0035000171
53. Wischmeyer P. E., Musch M. W., Madonna M. B., Thisted R., Chang E. B., Glutamine protects intestinal epithelial cells: role of inducible HSP70. American Journal of Physiology 1997 272 4 G879 G884 2-s2.0-0030962244
54. Musch M. W., Hayden D., Sugi K., Straus D., Chang E. B., Cell-specific induction of hsp72-mediated protection by glutamine against oxidant injury in IEC18 cells. Proceedings of the Association of American Physicians 1998 110 2 136 139 2-s2.0-0031895427
55. Chow A., Zhang R., Glutamine reduces heat shock-induced cell death in rat intestinal epithelial cells. Journal of Nutrition 1998 128 8 1296 1301 2-s2.0-0031877706
56. Pithon-Curi T. C., Schumacher R. I., Freitas J. J. S., Lagranha C., Newsholme P., Palanch A. C., Doi S. Q., Curi R., Glutamine delays spontaneous apoptosis in neutrophils. American Journal of Physiology 2003 284 6 C1355 C1361 2-s2.0-0038274020
57. Chang W. K., Yang K. D., Chuang H., Jan J. T., Shaio M. F., Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels. Clinical Immunology 2002 104 2 151 160 2-s2.0-0036051315 10.1006/clim.2002.5257
58. Jing L., Wu Q., Wang F., Glutamine induces heat-shock protein and protects against Escherichia coli lipopolysaccharide-induced vascular hyporeactivity in rats. Critical Care 2007 11, article R34 2-s2.0-39549096469 10.1186/cc5717
59. Hu Y. M., Pai M. H., Yeh C. L., Hou Y. C., Yeh S. L., Glutamine administration ameliorates sepsis-induced kidney injury by down regulating the high-mobility group box protein-1-mediated pathway in mice. American Journal of Physiology 2012 302 1 150 158 10.1152/ajprenal.00246.2011
60. Kwon W. Y., Suh G. J., Kim K. S., Jo Y. H., Lee J. H., Kim K., Jung S. K., Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis. British Journal of Nutrition 2010 103 6 890 898 2-s2.0-77950344552 10.1017/S0007114509992509
61. Singleton K. D., Serkova N., Beckey V. E., Wischmeyer P. E., Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. Critical Care Medicine 2005 33 6 1206 1213 2-s2.0-20444463157 10.1097/01.CCM.0000166357.10996.8A
62. Ugurlucan M., Erer D., Karatepe O., Ziyade S., Haholu A., Gungor Ugurlucan F., Filizcan U., Tireli E., Dayioglu E., Alpagut U., Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus. Expert Opinion on Therapeutic Targets 2010 14 11 1143 1156 2-s2.0-77958040496 10.1517/14728222. 2010.521500
63. Wischmeyer P. E., Lynch J., Liedel J., Wolfson R., Riehm J., Gottlieb L., Kahana M., Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Critical Care Medicine 2001 29 11 2075 2080 2-s2.0-0035168102
64. Singleton K. D., Wischmeyer P. E., Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. Shock 2006 25 3 295 299 2-s2.0-33646084611 10.1097/01.shk.0000196548.10634.02
65. Iwashita Y., Sakiyama T., Musch M. W., Ropeleski M. J., Tsubouchi H., Chang E. B., Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. American Journal of Physiology 2011 301 1 G181 G187 2-s2.0-79959852243 10.1152/ajpgi.00054.2011
66. Sonna L. A., Hawkins L., Lissauer M. E., Maldeis P., Towns M., Johnson S. B., Moore R., Singh I. S., Cowan M. J., Hasday J. D., Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS. Cell Stress & Chaperones 2010 15 1 55 66 2-s2.0-77449132102
67. Gelain D. P., De Bittencourt Pasquali M. A., Comim C. M., Grunwald M. S., Ritter C., Tomasi C. D., Alves S. C., Quevedo J., Dal-Pizzol F., Moreira J. C. F., Serum heat shock protein 70 levels, oxidant status, and mortality in sepsis. Shock 2011 35 5 466 470 2-s2.0-79955531732 10.1097/SHK.0b013e31820fe704
68. McConnell K. W., Fox A. C., Clark A. T., Chang N. Y. N., Dominguez J. A., Farris A. B., Buchman T. G., Hunt C. R., Coopersmith C. M., The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. Journal of Immunology 2011 186 6 3718 3725 2-s2.0-79953186909 10.4049/jimmunol.1003652
69. Kee C., Cheong K. Y., Pham K., Waterer G. W., Temple S. E. L., Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype. International Journal of Immunogenetics 2008 35 6 465 473 2-s2.0-55949088510 10.1111/j.1744-313X.2008.00812.x
70. Waterer G. W., ElBahlawan L., Quasney M. W., Zhang Q., Kessler L. A., Wunderink R. G., Heat shock protein 70-2 + 1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Critical Care Medicine 2003 31 5 1367 1372 2-s2.0-0037568026 10.1097/01.CCM.0000063088.86079. 03
71. Garrett-Cox R. G., Pierro A., Spitz L., Eaton S., Body temperature and heat production in suckling rat endotoxaemia: beneficial effects of glutamine. Journal of Pediatric Surgery 2003 38 1 37 44 2-s2.0-0037239932 10.1053/jpsu.2003.50006
72. Ladd F. V. L., Ladd A. A. B. L., Ribeiro A. A. C. M., Costa S. B. C., Coutinho B. P., Feitosa G. A. S., de Andrade G. M., Maurício de Castro-Costa C., Magalhães C. E. C., Castro I. C., Oliveira B. B., Guerrant R. L., Lima A. T. M., Oriá R. B., Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition. Nutrition 2010 26 6 662 670 2-s2.0-77952741356 10.1016/j.nut.2009.11.020
73. de Lima D. S. C., de Seixas Maia L. M. S., de Andrade Barboza E., de Almeida Duarte R., de Souza L. S., Guedes R. C. A., l-Glutamine supplementation during the lactation period facilitates cortical spreading depression in well-nourished and early-malnourished rats. Life Sciences 2009 85 5-6 241 247 2-s2.0-67649807445 10.1016/j.lfs.2009.05.017
74. Garrett-Cox R. G., Stefanutti G., Booth C., Klein N. J., Pierro A., Eaton S., Glutamine decreases inflammation in infant rat endotoxemia. Journal of Pediatric Surgery 2009 44 3 523 529 2-s2.0-62149145830 10.1016/j.jpedsurg.2008. 09.007
75. Potsic B., Holliday N., Lewis P., Samuelson D., DeMarco V., Neu J., Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology. Pediatric Research 2002 52 3 430 436 2-s2.0-0036707964 10.1203/01.PDR.0000025347.92120.02
76. Poindexter B. B., Ehrenkranz R. A., Stoll B. J., Wright L. L., Poole W. K., Oh W., Bauer C. R., Papile L. A., Tyson J. E., Carlo W. A., Laptook A. R., Narendran V., Stevenson D. K., Fanaroff A. A., Korones S. B., Shankaran S., Finer N. N., Lemons J. A., Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 2004 113 5 1209 1215 2-s2.0-2342512870 10.1542/peds.113.5. 1209
77. Kalhan S. C., Parimi P. S., Gruca L. L., Hanson R. W., Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. Journal of Pediatrics 2005 146 5 642 647 2-s2.0-18144366579 10.1016/j.jpeds.2005.01.022
78. Thompson S. W., McClure B. G., Tubman T. R. J., A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates. Journal of Pediatric Gastroenterology and Nutrition 2003 37 5 550 553 2-s2.0-1542599161 10.1097/00005176-200311000-00008
79. Albers M. J. I. J., Steyerberg E. W., Hazebroek F. W. J., Mourik M., Borsboom G. J. J. M., Rietveld T., Huijmans J. G. M., Tibboel D., Glutamine supplementation of parenteral nutrition does not improve intestinal permeability, nitrogen balance, or outcome in newborns and infants undergoing digestive-tract surgery: results from a double-blind, randomized, controlled trial. Annals of Surgery 2005 241 4 599 606 2-s2.0-15444368903 10.1097/01.sla.0000157270.24991.71
80. Des Robert C., Bacquer O. L., Piloquet H., Rozé J. C., Darmaun D., Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: a stable isotope study. Pediatric Research 2002 51 1 87 93 2-s2.0-0036134573
81. Li Z. H., Wang D. H., Dong M., Effect of parenteral glutamine supplementation in premature infants. Chinese Medical Journal 2007 120 2 140 144 2-s2.0-33947544127
82. Lacey J. M., Crouch J. B., Benfell K., Rlnger S. A., Wilmore C. K., Maguire D., Wilmore D. W., The effects of glutamine-supplemented parenteral nutrition in premature infants. Journal of Parenteral and Enteral Nutrition 1996 20 1 74 80 2-s2.0-0030071930
83. Poindexter B. B., Ehrenkranz R. A., Stoll B. J., National Institute of Child Health and Human Development Neonatal Research Network, Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants. The American Journal of Clinical Nutrition 2003 77 3 737 743
84. Wang Y., Tao Y. X., Cai W., Tang Q. Y., Feng Y., Wu J., Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants. Clinical Nutrition 2010 29 3 307 311 2-s2.0-77953535124 10.1016/j.clnu.2010.03.009
85. Ong E. G., Eaton S., Wade A. M., Horn V., Losty P. D., Curry J. I., Sugarman I. D., Klein N. J., Pierro A., On Behalf of Members of the SIGN Trial Group, Randomized clinical trial of glutamine-supplemented versus standard parenteral nutrition in infants with surgical gastrointestinal disease. British Journal of Surgery 2012 99 7 929 938 10.1002/bjs.8750
86. Neu J., Roig J. C., Meetze W. H., Veerman M., Carter C., Millsaps M., Bowling D., Dallas M. J., Sleasman J., Knight T., Auestad N., Enteral glutamine supplementation for very low birth weight infants decreases morbidity. Journal of Pediatrics 1997 131 5 691 699 2-s2.0-0030844172
87. Vaughn P., Thomas P., Clark R., Neu J., Enteral glutamine supplementation and morbidity in low birth weight infants. Journal of Pediatrics 2003 142 6 662 668 2-s2.0-0038809807 10.1067/mpd.2003.208
88. Van Den Berg A., Van Elburg R. M., Westerbeek E. A. M., Twisk J. W. R., Fetter W. P. F., Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. American Journal of Clinical Nutrition 2005 81 6 1397 1404 2-s2.0-21944453541
89. van den Berg A., van Elburg R. M., Westerbeek E. A. M., van der Linde E. G. M., Knol J., Twisk J. W. R., Fetter W. P. F., The effect of glutamine-enriched enteral nutrition on intestinal microflora in very low birth weight infants: a randomized controlled trial. Clinical Nutrition 2007 26 4 430 439 2-s2.0-34447627676 10.1016/j.clnu.2007.03.002
90. Van Den Berg A., Fetter W. P. F., Westerbeek E. A. M., Van Der Vegt I. M., Van Der Molen H. R. A., Van Elburg R. M., The effect of glutamine-enriched enteral nutrition on intestinal permeability in very-low-birth-weight infants: a randomized controlled trial. Journal of Parenteral and Enteral Nutrition 2006 30 5 408 414 2-s2.0-33846208881 10.1177/0148607106030005408
91. Van Den Berg A., Van Elburg R. M., Vermeij L., Van Zwol A., Van Den Brink G. R., Twisk J. W. R., Nieuwenhuis E. E. S., Fetter W. P. F., Cytokine responses in very low birth weight infants receiving glutamine-enriched enteral nutrition. Journal of Pediatric Gastroenterology and Nutrition 2009 48 1 94 101 2-s2.0-63649132300 10.1097/MPG.0b013e3181805116
92. Briassoulis G., Filippou O., Hatzi E., Papassotiriou I., Hatzis T., Early enteral administration of immunonutrition in critically ill children: results of a blinded randomized controlled clinical trial. Nutrition 2005 21 7-8 799 807 2-s2.0-20444493247 10.1016/j.nut.2004.12.006
93. Briassoulis G., Filippou O., Kanariou M., Hatzis T., Comparative effects of early randomized immune or non-immune-enhancing enteral nutrition on cytokine production in children with septic shock. Intensive Care Medicine 2005 31 6 851 858 2-s2.0-21244486984 10.1007/s00134-005-2631-3
94. Briassoulis G., Filippou O., Kanariou M., Papassotiriou I., Hatzis T., Temporal nutritional and inflammatory changes in children with severe head injury fed a regular or an immune-enhancing diet: a randomized, controlled trial. Pediatric Critical Care Medicine 2006 7 1 56 62 2-s2.0-33646093982 10.1097/01.PCC.0000192339.44871.26
95. Namba T., Tanaka K., Hoshino T., Azuma A., Mizushima T., Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS ONE 2011 6 11 e27296
96. Heyland D. K., Samis A., Does immunonutrition in patients with sepsis do more harm than good? Intensive Care Medicine 2003 29 5 669 671 2-s2.0-0038631959
97. Xu J., Yunshi Z., Li R., Immunonutrition in surgical patients. Current Drug Targets 2009 10 8 771 777 2-s2.0-70350780386 10.2174/138945009788982432
98. Houdijk A. P. J., Rijnsburger E. R., Jansen J., Wesdorp R., Kweiss J., Mc Camish M. A., Teerlink T., Meuwissen S. G. M., Th Haarman H. J. M., Thijs L. G., Mvan Leeuwen P. A., Randomised trial of glut ami ne-enriched enterai nutrition on infectious morbidity in patients with multiple trauma. The Lancet 1998 352 9130 772 776 2-s2.0-0032487082
99. Bertolini G., Iapichino G., Radrizzani D., Facchini R., Simini B., Bruzzone P., Zanforlin G., Tognoni G., Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Medicine 2003 29 5 834 840 2-s2.0-0037617435
100. Grau T., Bonet A., Miambres E., Pieiro L., Irles J. A., Robles A., Acosta J., Herrero I., Palacios V., Lopez J., Blesa A., Martínez P., The effect of l-alanyl-l-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients. Critical Care Medicine 2011 39 6 1263 1268 2-s2.0-79957666867 10.1097/CCM.0b013e31820eb774
101. Andrews P. J., Avenell A., Noble D. W., Campbell M. K., Croal B. L., Simpson W. G., Vale L. D., Battison C. G., Jenkinson D. J., Cook J. A., Scottish Intensive care Glutamine or seleNium Evaluative Trial Trials Group, Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. British Medical Journal 2011 342 d1542 2-s2.0-79955690712 10.1136/bmj.d1542
102. Tubman T. R., Thompson S. W., McGuire W., Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database of Systematic Reviews 2008 1 CD001457 2-s2.0-18944362437
103. Barbosa E., Moreira E. A., Goes J. E., Faintuch J., Pilot study with a glutamine-supplemented enteral formula in critically ill infants. Revista do Hospital das Clínicas 1999 54 1 21 24 2-s2.0-0032605048
104. Parimi P. S., Devapatla S., Gruca L. L., Amini S. B., Hanson R. W., Kalhan S. C., Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants. American Journal of Clinical Nutrition 2004 79 3 402 409 2-s2.0-1642398155
105. Van Der Schoor S. R. D., Schierbeek H., Bet P. M., Vermeulen M. J., Lafeber H. N., Van Goudoever J. B., Van Elburg R. M., Majority of dietary glutamine is utilized in first pass in preterm infants. Pediatric Research 2010 67 2 194 199 2-s2.0-77449160789 10.1203/PDR.0b013e3181c34609
106. Roig J. C., Meetze W. H., Auestad N., Jasionowski T., Veerman M., Mcmurray C. A., Neu J., Enteral glutamine supplementation for the very low birthweight infant: plasma amino acid concentrations. Journal of Nutrition 1996 126 4 1115S 1120S 2-s2.0-0029979198
107. Van Den Berg A., Van Elburg R. M., Teerlink T., Lafeber H. N., Twisk J. W. R., Fetter W. P. F., A randomized controlled trial of enteral glutamine supplementation in very low birth weight infants: plasma amino acid concentrations. Journal of Pediatric Gastroenterology and Nutrition 2005 41 1 66 71 2-s2.0-22044442965 10.1097/01.mpg.0000167497.55321.65
108. Van Den Berg A., Van Zwol A., Moll H. A., Fetter W. P. F., Van Elburg R. M., Glutamine-enriched enteral nutrition in very low-birth-weight infants: effect on the incidence of allergic and infectious diseases in the first year of life. Archives of Pediatrics and Adolescent Medicine 2007 161 11 1095 1101 2-s2.0-35948963986 10.1001/archpedi.161.11.1095
109. Van Zwol A., Moll H. A., Fetter W. P. F., Van Elburg R. M., Glutamine-enriched enteral nutrition in very low birthweight infants and allergic and infectious diseases at 6 years of age. Paediatric and Perinatal Epidemiology 2011 25 1 60 66 2-s2.0-78650145676 10.1111/j.1365-3016.2010.01173.x
110. Van Zwol A., Van Den Berg A., Huisman J., Vermeulen R. J., Fetter W. P., Twisk J. W. R., Van Elburg R. M., Neurodevelopmental outcomes of very low-birth-weight infants after enteral glutamine supplementation in the neonatal period. Acta Paediatrica, International Journal of Paediatrics 2008 97 5 562 567 2-s2.0-41749096400 10.1111/j.1651-2227.2008.00719.x
111. Van Zwol A., Van Den Berg A., Knol J., Twisk J. W. R., Fetter W. P. F., Van Elburg R. M., Intestinal microbiota in allergic and nonallergic 1-year-old very low birth weight infants after neonatal glutamine supplementation. Acta Paediatrica, International Journal of Paediatrics 2010 99 12 1868 1874 2-s2.0-78349240654 10.1111/j.1651-2227.2010.01934.x
112. Van Zwol A., Van Den Berg A., Nieuwenhuis E. E. S., Twisk J. W. R., Fetter W. P. F., Van Elburg R. M., Cytokine profiles in 1-yr-old very low-birth-weight infants after enteral glutamine supplementation in the neonatal period. Pediatric Allergy and Immunology 2009 20 5 467 470 2-s2.0-68349117326 10.1111/j.1399-3038.2008.00813.x
113. de Kieviet J. F., Oosterlaan J., van Zwol A., Boehm G., Lafeber H. N., van Elburg R. M., Effects of neonatal enteral glutamine supplementation on cognitive, motor and behavioural outcomes in very preterm and/or very low birth weight children at school age. British Journal of Nutrition 2012 7 1 6
114. Chuntrasakul C., Siltham S., Sarasombath S., Sittapairochana C., Leowattana W., Chockvivatanavanit S., Bunnak A., Comparison of a immunonutrition formula enriched arginine, glutamine and omega-3 fatty acid, with a currently high-enriched enteral nutrition for trauma patients. Journal of the Medical Association of Thailand 2003 86 6 552 561 2-s2.0-0042932690
115. Yang D. L., Xu J. F., Effect of dipeptide of glutamine and alanine on severe traumatic brain injury. Chinese Journal of Traumatology 2007 10 3 145 149 2-s2.0-34250180926
116. Eroglu A., The effect of intravenous alanyl-glutamine supplementation on plasma glutathione levels in intensive care unit trauma patients receiving enteral nutrition: the results of a randomized controlled trial. Anesthesia and Analgesia 2009 109 2 502 505 2-s2.0-67849088806 10.1213/ane.0b013e3181a83178
117. Luo M., Bazargan N., Griffith D. P., Estívariz C. F., Leader L. M., Easley K. A., Daignault N. M., Hao L., Meddings J. B., Galloway J. R., Blumberg J. B., Jones D. P., Ziegler T. R., Metabolic effects of enteral versus parenteral alanyl-glutamine dipeptide administration in critically ill patients receiving enteral feeding: a pilot study. Clinical Nutrition 2008 27 2 297 306 2-s2.0-41349117792 10.1016/j.clnu.2007.12.003
118. Soguel L., Chioléro R. L., Ruffieux C., Berger M. M., Monitoring the clinical introduction of a glutamine and antioxidant solution in critically ill trauma and burn patients. Nutrition 2008 24 11-12 1123 1132 2-s2.0-53449085803 10.1016/j.nut.2008.05.024
119. Mok E., Hankard R., Glutamine supplementation in sick children: is it beneficial? Journal of Nutrition and Metabolism 2011 2011 41 617597
120. Skillman H. E., Mehta N. M., Nutrition therapy in the critically ill child. Current Opinion in Critical Care 2012 18 2 192 198 10.1097/MCC. 0b013e3283514ba7