Does immunonutrition in patients with sepsis do more harm than good?

Intensive Care Medicine

Volumn 29, Issue 5, 2003, Pages 669-671

  Heyland, Daren K ^a   Samis, Andrew ^b  

^a KINGSTON GENERAL HOSPITAL   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ARGININE; BETA CAROTENE; CYTOKINE; OMEGA 3 FATTY ACID; OSMOLITE; PARENTERAL SOLUTION; RETINOL; SELENIUM; ZINC;

CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; EDITORIAL; ENTERIC FEEDING; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; IMPACT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NUTRITIONAL SUPPORT; PARENTERAL NUTRITION; RANDOMIZED CONTROLLED TRIAL; SEPSIS;

EID: 0038631959     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-003-1710-6     Document Type: Editorial

References (9)

1. Heyland DK, Novak F, Drover J, Jain M, Suchner U (2001) Should immunonutrition become routine in critically ill patients: a systematic review of the evidence. JAMA 286:944-953
2. Bower RH, Cerra FB, Bershadsky B, Licari JJ, Hoyt DB, Jensen GL, et al (1995) Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit Care Med 23:436-449
3. Dent DL, Heyland DK, Levy H, Martindale R, Tayek J, Schloerb P, Kelley MJ (2003) Immunonutrition may increase mortality in critically ill patients with pneumonia: results of a randomized trial. Crit Care Med 30:A17
4. Galban C, Montejo JC, Mesejo A, et al (2000) An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit Care Med 28:643-648
5. Heyland DK, MacDonald S, Keefe L, Drover JW (1998) Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA 280:2013-2019
6. Basttistella FD, Widergren JT, Anderson JT, et al (1997) A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma 43:52-58
7. Bruins MJ, Soeters PB, Larners WH, Meijer AJ, Deutz NEP (2002) L-Arginine supplementation in hyperdynamic endotoxemic pigs: effect on nitric oxide synthesis by different organs. Crit Care Med 30:508-517
8. Suchner U, Heyland DK, Peter K (2002) Immune-modulating actions of arginine in the critically ill. Br J Nutr 87[Suppl 1]:S121-132
9. Heyland DK (2002) Immunonutrition in the critically ill patient: putting the cart before the horse? Nutr Clin Pract 17:267-272