Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus

Expert Opinion on Therapeutic Targets

Volumn 14, Issue 11, 2010, Pages 1143-1156

  Ugurlucan, Murat ^a,b   Erer, Dilek ^c   Karatepe, Oguzhan ^d   Ziyade, Sedat ^e   Haholu, Aptullah ^f   Gungor Ugurlucan, Funda ^a   Filizcan, Ugur ^g   Tireli, Emin ^a   Dayioglu, Enver ^a   Alpagut, Ufuk ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b Duzce Ataturk State Hospital   (Turkey)

^c Department of Cardiovascular Surgery ^*  (Turkey)

^d OKMEYDANI TRAINING AND RESEARCH HOSPITAL   (Turkey)

^e VAKIF GUREBA HOSPITAL   (Turkey)

^f GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

^g DR SIYAMI ERSEK THORACIC AND CARDIOVASCULAR SURGERY TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Atherosclerosis; Diabetes mellitus; Glutamine; Heat shock protein 70; Myocardium

Indexed keywords

GLUCOSE; GLUTAMINE; HEAT SHOCK PROTEIN 70; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART PROTECTION; HEART RIGHT ATRIUM; HEART RIGHT VENTRICLE; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RAT; STREPTOZOCIN DIABETES; TISSUE DISTRIBUTION; TISSUE LEVEL;

ANIMALS; BLOOD GLUCOSE; CARDIOTONIC AGENTS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; GLUTAMINE; HEART; HEART ATRIA; HEART VENTRICLES; HSP70 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; MALE; MYOCARDIUM; PILOT PROJECTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 77958040496     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.2010.521500     Document Type: Article

References (26)

1. D'souza A, Hussain M, Howarth FC, et al. Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart. Mol Cell Biochem 2009;331:89-116
2. Mytas DZ, Stougiannos PN, Zairis MN, et al. Diabetic myocardial disease: pathophysiology, early diagnosis and therapeutic options. J Diabetes Complications 2009;23:273-282
3. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236-1241
4. Stefanadis C, Dernellis J, Tsiamis E, et al. Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease. Eur Heart J 2000;21:390-396
5. Binder RJ, Vatner R, Srivastava P. The heat-shock protein receptors: some answers and more questions. Tissue Antigens 2004;64:442-451
6. Giannessi D, Caselli C, Vitale RL, et al. A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients. Pharmacol Res 2003;48(5):519-529
7. Dybdahl B, Wahba A, Haaverstad R, et al. On-pump versus off-pump coronary artery bypass grafting: more heat-shock protein 70 is released after on-pump surgery. Eur J Cardiothorac Surg 2004;25:985-992
8. Ugurlucan M, Erer D, Kalko Y, et al. Aortic stiffness in diabetes mellitus - association with glutamine and heat shock protein 70 expression: a pilot study based on an experimental rodent model. Expert Opin Ther Targets 2009;13:267-274
9. Selimoglu O, Ugurlucan M, Basaran M, et al. Efficacy of remote ischaemic preconditioning for spinal cord protection against ischaemic injury: association with heat shock protein expression. Folia Neuropathol 2008;46:204-212
10. Freedman DS, Gruchow HW, Bamrah VS, et al. Diabetes mellitus and arteriographically-documented coronary artery disease. J Clin Epidemiol 1988:41:659-668
11. Monnier VM, Vishwanath V, Frank KE, et al. Relation between complications of type 1 diabetes mellitus and collagen-linked fluorescence. N Engl J Med 1996;314:403-408
12. Rutter MK, McComb JM, Brady S, Marshall SM. Silent myocardial ischemia and microalbuminuria in asymptomatic subjects with non-insulin-dependent diabetes mellitus. Am J Cardiol 1999;83:27-31
13. Haffner SM, Stern MP, Hazuda HP, et al. Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990;263:2893-2898
14. Parsell DA, Taulien J, Lindquist S. The role of heat-shock proteins in thermotolerance. Philos Trans R Soc Lond B Biol Sci 1993;339:279-285
15. Nomura F, Aoki M, Forbess JM, Mayer JE Jr. Myocardial self-preservative effect of heat shock protein 70 on an immature lamb heart. Ann Thorac Surg 1999;68:1736-1741
16. Suzuki K, Murtuza B, Sammut IA, et al. Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation 2002;106(12 Suppl 1):I270-76
17. Dillmann WH, Mehta HB, Barrieux A, et al. Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71. Circ Res 1986;59:110-114
18. Pockley AG, Georgiades A, Thulin T, et al. Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension. Hypertension 2003;42:235-238
19. Aneja R, Odoms K, Dunsmore K, et al. TNF-alpha decreases hsp 27 in human blood mononuclear cells: involvement of protein kinase C. Life Sci 2006;80:181-186
20. Hutter MM, Sievers RE, Barbosa V, Wolfe CL. Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation 1994;89:355-360
21. Hayashi Y, Sawa Y, Fukuyama N, et al. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity. Circulation 2002;106:2601-2607
22. Wang R, Town T, Gokarn V, et al. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. J Surg Res 2006;136:58-69
23. Schulman D, Latchman DS, Yellon DM. Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2001;281:H1630-36
24. Mandal K, Torsney E, Poloniecki J, et al. Association of high intracellular, but not serum, heat shock protein 70 with postoperative atrial fibrillation. Ann Thorac Surg 2005;79:865-871
25. Singleton KD, Wischmeyer PE. Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. Shock 2006;25:295-299
26. Singleton KD, Serkova N, Beckey VE, Wischmeyer PE. Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. Crit Care Med 2005;33:1206-1213 (Pubitemid 40827366)