Gut Microbiota Drives Metabolic Disease in Immunologically Altered Mice

Advances in Immunology

Volumn 116, Issue , 2012, Pages 93-112

  Chassaing, Benoit ^a   Aitken, Jesse D ^a   Gewirtz, Andrew T ^a   Vijay Kumar, Matam ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Chronic inflammation; Gut microbiota; Metabolic disease; Pattern Recognition Receptor

Indexed keywords

INFLAMMASOME; PATTERN RECOGNITION RECEPTOR; PREBIOTIC AGENT; PROBIOTIC AGENT; TOXIC SUBSTANCE;

ADAPTIVE IMMUNITY; ARTICLE; DIET; ENTERITIS; HOMEOSTASIS; HUMAN; IMMUNE DEFICIENCY; INNATE IMMUNITY; INTESTINE FLORA; LIPID ABSORPTION; METABOLIC DISORDER; MICROBIAL BIOMASS; MOUSE; MUSCLE ATROPHY; NONHUMAN; OBESITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYMBIOSIS; WEIGHT REDUCTION;

EID: 84867363434     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394300-2.00003-X     Document Type: Chapter

References (65)

1. Ajslev T.A., Andersen C.S., Gamborg M., Sorensen T.I., Jess T. Childhood overweight after establishment of the gut microbiota: The role of delivery mode, pre-pregnancy weight and early administration of antibiotics. International Journal of Obesity 2011, 35:522-529.
2. Andreasen A.S., Larsen N., Pedersen-Skovsgaard T., Berg R.M., Moller K., Svendsen K.D., et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. The British Journal of Nutrition 2010, 104:1831-1838.
3. Backhed F., Ding H., Wang T., Hooper L.V., Koh G.Y., Nagy A., et al. The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences 2004, 101:15718-15723.
4. Bajaj J.S., Ridlon J.M., Hylemon P.B., Thacker L.R., Heuman D.M., Smith S., et al. Linkage of gut microbiome with cognition in hepatic encephalopathy. American Journal of Physiology. Gastrointestinal and Liver Physiology 2012, 302:G168-G175.
5. Barrera J.G., Sandoval D.A., D'Alessio D.A., Seeley R.J. GLP-1 and energy balance: An integrated model of short-term and long-term control. Nature Reviews. Endocrinology 2011, 7:507-516.
6. Biswas S.K., Lopez-Collazo E. Endotoxin tolerance: New mechanisms, molecules and clinical significance. Trends in Immunology 2009, 30:475-487.
7. Brugman S., Klatter F.A., Visser J.T., Wildeboer-Veloo A.C., Harmsen H.J., Rozing J., et al. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?. Diabetologia 2006, 49:2105-2108.
8. Cani P.D., Amar J., Iglesias M.A., Poggi M., Knauf C., Bastelica D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-1772.
9. Cani P.D., Bibiloni R., Knauf C., Waget A., Neyrinck A.M., Delzenne N.M., et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57:1470-1481.
10. Cani P.D., Delzenne N.M. The role of the gut microbiota in energy metabolism and metabolic disease. Current Pharmaceutical Design 2009, 15:1546-1558.
11. Cani P.D., Hoste S., Guiot Y., Delzenne N.M. Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. The British Journal of Nutrition 2007, 98:32-37.
12. Cani P.D., Lecourt E., Dewulf E.M., Sohet F.M., Pachikian B.D., Naslain D., et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. The American Journal of Clinical Nutrition 2009, 90:1236-1243.
13. Cani P.D., Possemiers S., Van de Wiele T., Guiot Y., Everard A., Rottier O., et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009, 58:1091-1103.
14. Caricilli A.M., Picardi P.K., de Abreu L.L., Ueno M., Prada P.O., Ropelle E.R., et al. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biology 2011, 9:e1001212.
15. Carvalho F.A., Nalbantoglu I., Ortega-Fernandez S., Aitken J.D., Su Y., Koren O., et al. Interleukin-1beta (IL-1beta) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2012, 61:373-384.
16. Chen J., Hartono J.R., John R., Bennett M., Zhou X.J., Wang Y., et al. Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney International 2011, 80:504-515.
17. Chow J., Lee S.M., Shen Y., Khosravi A., Mazmanian S.K. Host-bacterial symbiosis in health and disease. Advances in Immunology 2010, 107:243-274.
18. Clements A., Young J., Constantinou N., Frankel G. Infection strategies of enteric pathogenic E. coli. Gut Microbes 2012, 3:71-87.
19. Cover T.L., Blaser M.J. Helicobacter pylori in health and disease. Gastroenterology 2009, 136:1863-1873.
20. Darfeuille-Michaud A. Adherent-invasive Escherichia coli: A putative new E. coli pathotype associated with Crohn's disease. International Journal of Medical Microbiology 2002, 292:185-193.
21. De Filippo C., Cavalieri D., Di Paola M., Ramazzotti M., Poullet J.B., Massart S., et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:14691-14696.
22. Delzenne N.M., Neyrinck A.M., Backhed F., Cani P.D. Targeting gut microbiota in obesity: Effects of prebiotics and probiotics. Nature Reviews. Endocrinology 2011, 7:639-646.
23. Field B.C., Chaudhri O.B., Bloom S.R. Bowels control brain: Gut hormones and obesity. Nature Reviews. Endocrinology 2010, 6:444-453.
24. Flegal K.M., Carroll M.D., Ogden C.L., Curtin L.R. Prevalence and trends in obesity among US adults, 1999-2008. JAMA: The Journal of the American Medical Association 2010, 303:235-241.
25. Furrie E., Macfarlane S., Thomson G., Macfarlane G.T. Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology 2005, 115:565-574.
26. Gewirtz A.T., Navas T.A., Lyons S., Godowski P.J., Madara J.L. Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. Journal of Immunology 2001, 167:1882-1885.
27. Ghadimi D., Vrese M., Heller K.J., Schrezenmeir J. Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells. Inflammatory Bowel Diseases 2010, 16:410-427.
28. Hamer H.M., Jonkers D., Venema K., Vanhoutvin S., Troost F.J., Brummer R.J. Review article: The role of butyrate on colonic function. Alimentary Pharmacology & Therapeutics 2008, 27:104-119.
29. Henao-Mejia J., Elinav E., Jin C., Hao L., Mehal W.Z., Strowig T., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
30. Hildebrandt M.A., Hoffmann C., Sherrill-Mix S.A., Keilbaugh S.A., Hamady M., Chen Y.Y., et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009, 137(1716-1724):e1711-e1712.
31. Hoffmann C., Hill D.A., Minkah N., Kirn T., Troy A., Artis D., et al. Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing. Infection and Immunity 2009, 77:4668-4678.
32. Hooper L.V., Midtvedt T., Gordon J.I. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annual Review of Nutrition 2002, 22:283-307.
33. Hoshi H., Aijima H., Horie K., Nagata H., Kaneko T., Ikeda T. Lymph follicles and germinal centers in popliteal lymph nodes and other lymphoid tissues of germ-free and conventional rats. The Tohoku Journal of Experimental Medicine 1992, 166:297-307.
34. Hotamisligil G.S., Spiegelman B.M. Tumor necrosis factor alpha: A key component of the obesity-diabetes link. Diabetes 1994, 43:1271-1278.
35. Jenq R.R., Ubeda C., Taur Y., Menezes C.C., Khanin R., Dudakov J.A., et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. The Journal of Experimental Medicine 2012, 209:903-911.
36. Kadooka Y., Sato M., Imaizumi K., Ogawa A., Ikuyama K., Akai Y., et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. European Journal of Clinical Nutrition 2010, 64:636-643.
37. Kane M., Case L.K., Kopaskie K., Kozlova A., MacDearmid C., Chervonsky A.V., et al. Successful transmission of a retrovirus depends on the commensal microbiota. Science 2011, 334:245-249.
38. Kim H.K., Youn B.S., Shin M.S., Namkoong C., Park K.H., Baik J.H., et al. Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes 2010, 59:2772-2780.
39. Klijn A., Mercenier A., Arigoni F. Lessons from the genomes of bifidobacteria. FEMS Microbiology Reviews 2005, 29:491-509.
40. Kuss S.K., Best G.T., Etheredge C.A., Pruijssers A.J., Frierson J.M., Hooper L.V., et al. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science 2011, 334:249-252.
41. Lee Y.K., Menezes J.S., et al. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(Suppl 1):4615-4622.
42. Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I. Microbial ecology: Human gut microbes associated with obesity. Nature 2006, 444:1022-1023.
43. Li J.V., Ashrafian H., Bueter M., Kinross J., Sands C., Le Roux C.W., et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 2011, 60:1214-1223.
44. Liu X., Strable M.S., Ntambi J.M. Stearoyl CoA desaturase 1: Role in cellular inflammation and stress. Advances in Nutrition (Bethesda, MD) 2011, 2:15-22.
45. Lupp C., Robertson M.L., Wickham M.E., Sekirov I., Champion O.L., Gaynor E.C., et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host & Microbe 2007, 2:204.
46. Makiura N., Ojima M., Kou Y., Furuta N., Okahashi N., Shizukuishi S., et al. Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiology and Immunology 2008, 23:348-351.
47. Membrez M., Blancher F., Jaquet M., Bibiloni R., Cani P.D., Burcelin R.G., et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. The FASEB Journal 2008, 22:2416-2426.
48. O'Hara A.M., Shanahan F. The gut flora as a forgotten organ. EMBO Reports 2006, 7:688-693.
49. Oresic M., Seppanen-Laakso T., Yetukuri L., Backhed F., Hanninen V. Gut microbiota affects lens and retinal lipid composition. Experimental Eye Research 2009, 89:604-607.
50. Poggi M., Bastelica D., Gual P., Iglesias M.A., Gremeaux T., Knauf C., et al. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 2007, 50:1267-1276.
51. Samuel B.S., Shaito A., Motoike T., Rey F.E., Backhed F., Manchester J.K., et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:16767-16772.
52. Sandri S., Rodriguez D., Gomes E., Monteiro H.P., Russo M., Campa A. Is serum amyloid A an endogenous TLR4 agonist?. Journal of Leukocyte Biology 2008, 83:1174-1180.
53. Sellon R.K., Tonkonogy S., Schultz M., Dieleman L.A., Grenther W., Balish E., et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infection and Immunity 1998, 66:5224-5231.
54. Shin S.C., Kim S.H., You H., Kim B., Kim A.C., Lee K.A., et al. Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. Science 2011, 334:670-674.
55. Shulzhenko N., Morgun A., Hsiao W., Battle M., Yao M., Gavrilova O., et al. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nature Medicine 2011, 17:1585-1593.
56. Sibony M., Jones N.L. Recent advances in Helicobacter pylori pathogenesis. Current Opinion in Gastroenterology 2012, 28(1):30-35.
57. Slack E., Hapfelmeier S., Stecher B., Velykoredko Y., Stoel M., Lawson M.A., et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 2009, 325:617-620.
58. Snedeker S.M., Hay A.G. Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes?. Environmental Health Perspectives 2012, 120:332-339.
59. Turnbaugh P.J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., Gordon J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
60. Vamadevan A.S., Fukata M., Arnold E.T., Thomas L.S., Hsu D., Abreu M.T. Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: A comprehensive analysis. Innate Immunity 2010, 16:93-103.
61. Vijay-Kumar M., Aitken J.D., Carvalho F.A., Cullender T.C., Mwangi S., Srinivasan S., et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010, 328:228-231.
62. Vilaysane A., Muruve D.A. The innate immune response to DNA. Seminars in Immunology 2009, 21:208-214.
63. Wang Y., Beydoun M.A., Liang L., Caballero B., Kumanyika S.K. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 2008, 16:2323-2330.
64. Wang Z., Klipfell E., Bennett B.J., Koeth R., Levison B.S., Dugar B., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011, 472:57-63.
65. Wen L., Ley R.E., Volchkov P.Y., Stranges P.B., Avanesyan L., Stonebraker A.C., et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008, 455:1109-1113.