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1
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84856850830
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Stop the killing of beneficial bacteria
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Blaser MJ. Stop the killing of beneficial bacteria. Nature 2011; 476:887-894.
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(2011)
Nature
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Blaser, M.J.1
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77952692062
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Association between Helicobacter pylori infection and inflammatory bowel disease: A meta-analysis and systematic review of the literature
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Luther J, Dave M, Higgins PD, Kao JY. Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature. Inflamm Bowel Dis 2010; 16:1077-1084.
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Inflamm Bowel Dis
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Luther, J.1
Dave, M.2
Higgins, P.D.3
Kao, J.Y.4
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3
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80054875484
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Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US Pathology Database
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Dellon ES, Peery AF, Shaheen NJ, et al. Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US Pathology Database. Gastroenterology 2011; 141:1586-1592.
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(2011)
Gastroenterology
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Dellon, E.S.1
Peery, A.F.2
Shaheen, N.J.3
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4
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34247547360
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Inverse associations of Helicobacter pylori with asthma and allergy
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DOI 10.1001/archinte.167.8.821
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Chen Y, Blaser MJ. Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med 2007; 167:821-827. (Pubitemid 46658341)
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(2007)
Archives of Internal Medicine
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Chen, Y.1
Blaser, M.J.2
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5
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79961210742
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Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children
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Koletzko S, Jones NL, Goodman K, et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr 2011; 53:23-43.
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(2011)
J Pediatr Gastroenterol Nutr
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, pp. 23-43
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Koletzko, S.1
Jones, N.L.2
Goodman, K.3
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6
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80054859726
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Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA
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Chaturvedi R, Asim M, Romero-Gallo J, et al. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology 2011; 141:1696-1708.
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(2011)
Gastroenterology
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Chaturvedi, R.1
Asim, M.2
Romero-Gallo, J.3
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7
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80051506744
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Beta-catenin and p120 mediate PPARdelta-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia
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Nagy TA, Wroblewski LE, Wang D, et al. Beta-catenin and p120 mediate PPARdelta-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology 2011; 141:553-564.
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(2011)
Gastroenterology
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Nagy, T.A.1
Wroblewski, L.E.2
Wang, D.3
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8
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77957353073
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Regulation of p53 tumour suppressor by Helicobacter pylori in gastric epithelial cells
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Wei J, Nagy TA, Vilgelm A, et al. Regulation of p53 tumour suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology 2010; 139: 133-143.
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(2010)
Gastroenterology
, vol.139
, pp. 133-143
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Wei, J.1
Nagy, T.A.2
Vilgelm, A.3
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9
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79959355340
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Helicobacter pylori cytotoxinassociated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host
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Buti L, Spooner E, Van der Veen AG, et al. Helicobacter pylori cytotoxinassociated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proc Natl Acad Sci USA 2011; 108:9238-9243.
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(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9238-9243
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Buti, L.1
Spooner, E.2
Van Der Veen, A.G.3
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10
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80052563887
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Mammalian pragmin regulates Srcfamily kinases via the EPIYA motif that is exploited by bacterial effectors
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Safari F, Murata-Kamiya N, Saito Y, et al. Mammalian pragmin regulates Srcfamily kinases via the EPIYA motif that is exploited by bacterial effectors. Proc Nat Acad Sci 2011; 108:14938-14943.
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(2011)
Proc Nat Acad Sci
, vol.108
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Safari, F.1
Murata-Kamiya, N.2
Saito, Y.3
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11
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79958745867
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Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori
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Tegtmeyer N, Wittelsberger R, Hartig R, et al. Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe 2011; 9:520-531.
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(2011)
Cell Host Microbe
, vol.9
, pp. 520-531
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Tegtmeyer, N.1
Wittelsberger, R.2
Hartig, R.3
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12
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79958040761
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The C-terminally encoded MHC class-IIrestricted T cell antigenicity of the Helicobacter pylori virulence factor CagA promotes gastric preneoplasia
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Arnold IC, Hitzler I, Engler D, et al. The C-terminally encoded, MHC class-IIrestricted T cell antigenicity of the Helicobacter pylori virulence factor CagA promotes gastric preneoplasia. J Immunol 2011; 186:6165-6172.
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(2011)
J Immunol
, vol.186
, pp. 6165-6172
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Arnold, I.C.1
Hitzler, I.2
Engler, D.3
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13
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78650498571
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Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia
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+ infection model to delineate the effects of toxigenic H. pylori infection and propose a mechanism to why a fraction of infected individuals develop pathologies. It has shown that age of infection plays a major part in predisposition to developing pathologies
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+ infection model to delineate the effects of toxigenic H. pylori infection and propose a mechanism to why a fraction of infected individuals develop pathologies. It has shown that age of infection plays a major part in predisposition to developing pathologies.
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(2011)
Gastroenterology
, vol.140
, pp. 199-209
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Arnold, I.C.1
Lee, J.Y.2
Amieva, M.R.3
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14
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78249272018
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Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA
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Gupta V, Wilson BA, Blanke SR. Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA. Cell Microbiol 2010; 12:1517-1533.
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(2010)
Cell Microbiol
, vol.12
, pp. 1517-1533
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Gupta, V.1
Wilson, B.A.2
Blanke, S.R.3
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15
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79951487830
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PKC-dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes
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Sewald X, Jimenez-Soto L, Haas R. PKC-dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. Cell Microbiol 2011; 13:482-496.
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(2011)
Cell Microbiol
, vol.13
, pp. 482-496
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Sewald, X.1
Jimenez-Soto, L.2
Haas, R.3
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16
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80053139817
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Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death
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Jain P, Luo ZQ, Blanke SR. Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death. Proc Natl Acad Sci USA 2011; 108:16032-16037.
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(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16032-16037
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Jain, P.1
Luo, Z.Q.2
Blanke, S.R.3
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17
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79960145527
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BabA-mediated adherence is a potentiator of the Helicobacter pylori Type IV secretion system activity
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Ishijima N, Suzuki M, Ashida H, et al. BabA-mediated adherence is a potentiator of the Helicobacter pylori Type IV secretion system activity. J Biol Chem 2011; 286:25256-25264.
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(2011)
J Biol Chem
, vol.286
, pp. 25256-25264
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Ishijima, N.1
Suzuki, M.2
Ashida, H.3
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18
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78650750316
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Helicobacter pylori proinflammatory protein upregulates NF-kB as a cell-translocating Ser/Thr kinase
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Kim DJ, Park KS, Kim JH, et al. Helicobacter pylori proinflammatory protein upregulates NF-kB as a cell-translocating Ser/Thr kinase. Proc Natl Acad Sci USA 2010; 107:21418-21423.
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(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 21418-21423
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Kim, D.J.1
Park, K.S.2
Kim, J.H.3
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19
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78649706953
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Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2 leading to gastric tumour development in mice and humans
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Peterson AJ, Menheniott TR, O'Connor L, et al. Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumour development in mice and humans. Gastroenterology 2010; 139:2006-2017.
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(2010)
Gastroenterology
, vol.139
, pp. 2006-2017
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Peterson, A.J.1
Menheniott, T.R.2
O'Connor, L.3
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20
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79959196668
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Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma
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Munari F, Lonardi S, Cassatella MA, et al. Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma. Blood 2011; 117:6612-6616.
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(2011)
Blood
, vol.117
, pp. 6612-6616
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Munari, F.1
Lonardi, S.2
Cassatella, M.A.3
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21
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78650432894
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Dysfunctional gastric emptying with down-regulation of muscle-specific microRNAs in Helicobacter pylori-infected mice
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This study showed that miRNA expression is affected by H. pylori exposure. Two miRNAs were identified to be downregulated in H. pylori infection, and their targets are involved in proliferation, hence might account for hyperplasia and associated gastric motility conditions
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Saito Y, Suzuki H, Tsugawa H, et al. Dysfunctional gastric emptying with down-regulation of muscle-specific microRNAs in Helicobacter pylori-infected mice. Gastroenterology 2011; 140:189-198. This study showed that miRNA expression is affected by H. pylori exposure. Two miRNAs were identified to be downregulated in H. pylori infection, and their targets are involved in proliferation, hence might account for hyperplasia and associated gastric motility conditions.
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(2011)
Gastroenterology
, vol.140
, pp. 189-198
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Saito, Y.1
Suzuki, H.2
Tsugawa, H.3
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22
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80052134584
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The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity
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The authors discover an interesting interaction between H. pylori and CD46, which proved to have anti-H. pylori properties in vivo
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Basmarke-Wehelie R, Sjolinder H, Jurkowski W, et al. The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity. Gastroenterology 2011; 141:918-928. The authors discover an interesting interaction between H. pylori and CD46, which proved to have anti-H. pylori properties in vivo.
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(2011)
Gastroenterology
, vol.141
, pp. 918-928
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Basmarke-Wehelie, R.1
Sjolinder, H.2
Jurkowski, W.3
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23
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78650496969
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Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
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this study, the authors sought to determine the role of commensal bacteria in the development of H. pylori-mediated pathologies. They used a gastrin overexpression to quantify the severity and time till the mice developed disease. Germfree mice took longer time to develop pathologies than monoassociated and specific pathogen-free (SPF) H. pylori-infected mice, whereas the SPF H. pylori mice developed a more severe phenotype than the monoassociated mice
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Lofgren JL, Whary MT, Ge Z, et al. Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology 2011; 140:210-220. In this study, the authors sought to determine the role of commensal bacteria in the development of H. pylori-mediated pathologies. They used a gastrin overexpression to quantify the severity and time till the mice developed disease. Germfree mice took longer time to develop pathologies than monoassociated and specific pathogen-free (SPF) H. pylori-infected mice, whereas the SPF H. pylori mice developed a more severe phenotype than the monoassociated mice.
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(2011)
Gastroenterology
, vol.140
, pp. 210-220
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Lofgren, J.L.1
Whary, M.T.2
Ge, Z.3
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24
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79251591965
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Prostaglandin E signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors
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Oshima H, Hioki K, Popivanova BK, et al. Prostaglandin E signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. Gastroenterology 2011; 140:596-607; e597.
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(2011)
Gastroenterology
, vol.140
, Issue.596-607
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Oshima, H.1
Hioki, K.2
Popivanova, B.K.3
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25
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80053568646
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Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis
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The authors show that H. pylori DNA carries unique immunoregulatory properties that are shed distally into the colon and are able to ameliorate colitis induced in animal models
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Luther J, Owyang SY, Takeuchi T, et al. Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis. Gut 2011; 60:1479-1486. The authors show that H. pylori DNA carries unique immunoregulatory properties that are shed distally into the colon and are able to ameliorate colitis induced in animal models.
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(2011)
Gut
, vol.60
, pp. 1479-1486
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Luther, J.1
Owyang, S.Y.2
Takeuchi, T.3
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26
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79960843789
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Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
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This study investigated the mechanism underlying the inverse association of H. pylori infection and asthma. Mice infected at neonatal stages displayed reduced rates of asthma, associated with an increase in Tregs and a decrease in dendritic cell maturation
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Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest 2011; 121:3088-3093. This study investigated the mechanism underlying the inverse association of H. pylori infection and asthma. Mice infected at neonatal stages displayed reduced rates of asthma, associated with an increase in Tregs and a decrease in dendritic cell maturation.
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(2011)
J Clin Invest
, vol.121
, pp. 3088-3093
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Arnold, I.C.1
Dehzad, N.2
Reuter, S.3
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27
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78650944895
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Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
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Chang YJ, Kim HY, Albacker LA, et al. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. J Clin Invest 2011; 121:57-69.
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(2011)
J Clin Invest
, vol.121
, pp. 57-69
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Chang, Y.J.1
Kim, H.Y.2
Albacker, L.A.3
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