Oroxylin-A Rescues LPS-Induced Acute Lung Injury via Regulation of NF-κB Signaling Pathway in Rodents

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Tseng, Tzu Ling ^a   Chen, Mei Fang ^a,b,c   Tsai, Ming Jen ^a,b   Hsu, Yung Hsiang ^a   Chen, Chin Piao ^d   Lee, Tony J F ^a,b,e  

^a TZU CHI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

^d NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^e SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OROXYLIN A; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENDOTOXEMIA; HISTOPATHOLOGY; LEUKOCYTE COUNT; LUNG ALVEOLUS WALL; LUNG EDEMA; MOUSE; NONHUMAN; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RAT; REGULATORY MECHANISM; RESPIRATORY TRACT INFLAMMATION; RODENT; SIGNAL TRANSDUCTION; SURVIVAL RATE;

ACUTE LUNG INJURY; ANALYSIS OF VARIANCE; ANIMALS; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84867362610     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047403     Document Type: Article

References (44)

1. Dreyfuss D, Ricard JD, (2005) Acute lung injury and bacterial infection. Clin Chest Med 26: 105-112.
2. Baumgarten G, Knuefermann P, Wrigge H, Putensen C, Stapel H, et al. (2006) Role of Toll-like receptor 4 for the pathogenesis of acute lung injury in Gram-negative sepsis. Eur J Anaesthesiol 23: 1041-1048.
3. Chen HI, Kao SJ, Wang D, Lee RP, Su CF, (2003) Acute respiratory distress syndrome. J Biomed Sci 10: 588-592.
4. Gu J, Korteweg C, (2007) Pathology and pathogenesis of severe acute respiratory syndrome. Am J Pathol 170: 1136-1147.
5. Jiang Y, Xu J, Zhou C, Wu Z, Zhong S, et al. (2005) Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Am J Respir Crit Care Med 171: 850-857.
6. Lange M, Nakano Y, Traber DL, Hamahata A, Esechie A, et al. (2010) Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis. Biochem Biophys Res Commun.
7. Farley KS, Wang LF, Law C, Mehta S, (2008) Alveolar macrophage inducible nitric oxide synthase-dependent pulmonary microvascular endothelial cell septic barrier dysfunction. Microvasc Res 76: 208-216.
8. Malleo G, Mazzon E, Siriwardena AK, Cuzzocrea S, (2007) TNF-alpha as a therapeutic target in acute pancreatitis-lessons from experimental models. ScientificWorldJournal 7: 431-448.
9. Speyer CL, Neff TA, Warner RL, Guo RF, Sarma JV, et al. (2003) Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 163: 2319-2328.
10. Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, et al. (2005) HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol 288: L958-965.
11. Yang H, Wang H, Czura CJ, Tracey KJ, (2005) The cytokine activity of HMGB1. J Leukoc Biol 78: 1-8.
12. Peltz ED, Moore EE, Eckels PC, Damle SS, Tsuruta Y, et al. (2009) HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock 32: 17-22.
13. Silva E, Arcaroli J, He Q, Svetkauskaite D, Coldren C, et al. (2007) HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury. Intensive Care Med 33: 1829-1839.
14. Numata M, Suzuki S, Miyazawa N, Miyashita A, Nagashima Y, et al. (1998) Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs. J Immunol 160: 3031-3037.
15. Luan ZG, Nala P, Zhang ZD, Ma XC, (2006) [Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18: 456-458.
16. Lamontagne F, Briel M, Guyatt GH, Cook DJ, Bhatnagar N, et al. (2009) Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: A meta-analysis of randomized controlled trials. J Crit Care.
17. Cheng PY, Lee YM, Wu YS, Chang TW, Jin JS, et al. (2007) Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro. Biochem Pharmacol 73: 793-804.
18. Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, et al. (2006) Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 354: 1671-1684.
19. Shapiro H, Lev S, Cohen J, Singer P, (2009) Polyphenols in the prevention and treatment of sepsis syndromes: rationale and pre-clinical evidence. Nutrition 25: 981-997.
20. Chen Y, Yang L, Lee TJ, (2000) Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem Pharmacol 59: 1445-1457.
21. Yi C, Cao Y, Mao SH, Liu H, Ji LL, et al. (2009) Recombinant human growth hormone improves survival and protects against acute lung injury in murine Staphylococcus aureus sepsis. Inflamm Res 58: 855-862.
22. Ni YF, Tian F, Lu ZF, Yang GD, Fu HY, et al. (2010) Protective Effect of Nicotine on Lipopolysaccharide-Induced Acute Lung Injury in Mice. Respiration.
23. Parker JC, Townsley MI, (2004) Evaluation of lung injury in rats and mice. Am J Physiol Lung Cell Mol Physiol 286: L231-246.
24. Martinez FE, Harabor A, Amankwah EK, Hart DA, Belik J, (2000) Urethane suppresses rat lung inducible cyclooxygenase and nitric oxide synthase mRNA levels. Inflamm Res 49: 727-731.
25. Kotanidou A, Choi AM, Winchurch RA, Otterbein L, Fessler HE, (1996) Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-alpha release. J Appl Physiol 81: 2305-2311.
26. Taniguchi T, Kanakura H, Takemoto Y, Kidani Y, Yamamoto K, (2003) Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats. Tohoku J Exp Med 200: 85-92.
27. Taniguchi T, Yamamoto K, Ohmoto N, Ohta K, Kobayashi T, (2000) Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. Crit Care Med 28: 1101-1106.
28. Tsuji C, Minhaz MU, Shioya S, Fukahori M, Tanigaki T, et al. (1998) The importance of polymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production and lung injury: ex vivo observation in rat lungs. Lung 176: 1-13.
29. Kitajima S, Tsuda M, Eshita N, Matsushima Y, Saitoh M, et al. (1995) Lipopolysaccharide-associated elevation of serum and urinary nitrite/nitrate levels and hematological changes in rats. Toxicol Lett 78: 135-140.
30. Unoshima M, (2004) [Therapeutic effect of anti-HMGB1 antibody and anti-RAGE antibody on SIRS/sepsis]. Nippon Rinsho 62: 2323-2329.
31. Iba T, Kidokoro A, Fukunaga M, Takuhiro K, Yoshikawa S, et al. (2006) Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters. Shock 26: 95-98.
32. Ding J, Song D, Ye X, Liu SF, (2009) A pivotal role of endothelial-specific NF-kappaB signaling in the pathogenesis of septic shock and septic vascular dysfunction. J Immunol 183: 4031-4038.
33. Vandenbroucke E, Mehta D, Minshall R, Malik AB, (2008) Regulation of endothelial junctional permeability. Ann N Y Acad Sci 1123: 134-145.
34. Su CF, Yang FL, Chen HI, (2007) Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats. Clin Exp Pharmacol Physiol 34: 339-346.
35. Guo ZY, Wang ST, Xu MH, Jiao Q, Gao FH, (2009) [Protective effects of rhu TNFR: Fc against the lipopolysaccharide induced intestinal damage of rats and its underlying mechanism]. Yao Xue Xue Bao 44: 586-590.
36. Bhattacharyya J, Biswas S, Datta AG, (2004) Mode of action of endotoxin: role of free radicals and antioxidants. Curr Med Chem 11: 359-368.
37. Kleinert H, Schwarz PM, Forstermann U, (2003) Regulation of the expression of inducible nitric oxide synthase. Biol Chem 384: 1343-1364.
38. Magnani M, Crinelli R, Bianchi M, Antonelli A, (2000) The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB). Curr Drug Targets 1: 387-399.
39. Galani V, Tatsaki E, Bai M, Kitsoulis P, Lekka M, et al. (2010) The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): an up-to-date cell-specific review. Pathol Res Pract 206: 145-150.
40. Ahmad TM, Afzal MN, (2010) Assessment of differential leukocyte count in patients with acute coronary syndrome. J Pak Med Assoc 60: 548-551.
41. Ahmadi K, Riazipour M, (2007) Effect of Ganoderma lucidum on cytokine release by peritoneal macrophages. Iran J Immunol 4: 220-226.
42. Zheng S, Zhang WY, Zhu LW, Lin K, Sun B, (2001) Surfactant and inhaled nitric oxide in rats alleviate acute lung injury induced by intestinal ischemia and reperfusion. J Pediatr Surg 36: 980-984.
43. Prows DR, Hafertepen AP, Gibbons WJ Jr, Winterberg AV, Nick TG, (2007) A genetic mouse model to investigate hyperoxic acute lung injury survival. Physiol Genomics 30: 262-270.
44. Chen YC, Shen SC, Chen LG, Lee TJ, Yang LL, (2001) Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 61: 1417-1427.