Role of toll-like receptor 4 for the pathogenesis of acute lung injury in gram-negative sepsis

European Journal of Anaesthesiology

Volumn 23, Issue 12, 2006, Pages 1041-1048

  Baumgarten, G ^a   Knuefermann, P ^a   Wrigge, H ^a   Putensen, C ^a   Stapel, H ^a   Fink, K ^a   Meyer, R ^a   Hoeft, A ^a   Grohé, Christian ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Cytokines; Inflammation; Mice; Respiratory distress syndrome adult; Sepsis syndrome; Toll like receptors

Indexed keywords

ARGININE; CD14 ANTIGEN; CITRULLINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; RIBONUCLEASE; SODIUM CHLORIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL COUNT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GRAM NEGATIVE SEPSIS; LUNG LAVAGE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD14; BRONCHOALVEOLAR LAVAGE FLUID; GRAM-NEGATIVE BACTERIA; INTERLEUKIN-1BETA; INTERLEUKIN-6; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C3H; NITRIC OXIDE; RESPIRATORY DISTRESS SYNDROME, ADULT; SHOCK, SEPTIC; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750301239     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021506001098     Document Type: Article

References (31)

1. Wheeler AP, Bernard GR. Treating patients with severe sepsis. New Engl J Med 1999; 340: 207-215.
2. Chow CW, Herrera Abreu MT, Suzuki T, Downey GP. Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol 2003; 29: 427-431.
3. Vincent JL, Akca S, De Mendonca A et al. The epidemiology of acute respiratory failure in critically ill patients. Chest 2002; 121: 1602-1609.
4. Stuber F, Wrigge H, Schroeder S et al. Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intens Care Med 2002; 28: 834-841.
5. Wrigge H, Zinserling J, Stuber F et al. Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function. Anesthesiology 2000; 93: 1413-1417.
6. Qu J, Zhang J, Pan J et al. Endotoxin talerance inhibits lipopolysaccharide-initiated acute pulmonary inflammation and lung injury in rats by the mechanism of nuclear factor-kappaB. Scand J Immunol 2003; 58: 613-619.
7. dos Santos CC, Han B, Andrade CF et al. DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch. Physiol Genomics 2004; 19: 331-342.
8. Baumgarten G, Knuefermann P, Nozaki N, Sivasubramanian N, Mann DL, Vallejo JG. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 2001; 183: 1617-1624.
9. Nemoto S, Vallejo JG, Knuefermann P et al. Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. Am J Physiol Heart Circ Physiol 2002; 282: H2316-H2323.
10. Knuefermann P, Nemoto S, Misra A et al. CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation 2002; 106: 2608-2615.
11. Baumgarten G, Knuefermann P, Schumacher G et al. Toll-Like receptor 4, NO and myocardial depression in endotoxemia. Shock 2006; 25(1): 43-49.
12. Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol 1999; 11: 13-18.
13. Beutler B. Innate immunity: an overview. Mol Immunol 2004; 40: 845-859.
14. Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
15. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999; 163: 1-5.
16. Schuster JM, Nelson PS. Toll receptors: an expanding role in our understanding of human disease. J Leukoc Biol 2000; 67: 767-773.
17. Frantz S, Kobzik L, Kim YD et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 1999; 104: 271-280.
18. Poltorak A, Smirnova I, He X et al. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis 1998; 24: 340-355.
19. Perera PY, Mayadas TN, Takeuchi O et al. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol 2001; 166: 574-581.
20. Knuefermann P, Chen P, Misra A, Shi SP, Abdellatif M, Sivasubramanian N. Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. J Biol Chem 2002; 277: 23888-23897.
21. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
22. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990; 347: 768-770.
23. Fonseca-Aten M, Rios AM, Mejias A et al. Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice. Am J Respir Cell Mol Biol 2005; 32: 201-210.
24. Fan J, Kapus A, Marsden PA et al. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol 2002; 168: 5252-5259.
25. Guillot L, Medjane S, Le Barillec K et al. Response of human pulmonary epithelial cells to LPS involves toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem 2004; 279(4): 2712-2718.
26. Oshikawa K, Sugiyama Y. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Biochem Biophys Res Commun 2003; 305: 649-655.
27. Fearns C, Kravchenko VV, Ulevitch RJ, Loskutoff DJ. Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med 1995; 181: 857-866.
28. Poynter ME, Irvin CG, Janssen-Heininger YM. A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. J Immunol 2003; 170: 6257-6265.
29. Cui X, Rouhani FN, Hawari F, Levine SJ. Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding. J Immunol 2003; 171: 6814-6819.
30. Jablonska E, Jabionski J, Holownia A et al. TNFRs and IL-6R transmembrane receptors expression and release of their soluble forms by neutrophils and mononuclear cells from cancer patients. Rocz Akad Med Bialymst 2001; 46: 113-125.
31. Lynn M, Rossignol DP, Wheeler JL et al. Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J Infect Dis 2003; 187: 631-639.