Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: A meta-analysis of randomized controlled trials

Journal of Critical Care

Volumn 25, Issue 3, 2010, Pages 420-435

  Lamontagne, François ^a,b   Briel, Matthias ^a,c   Guyatt, Gordon H ^a   Cook, Deborah J ^a   Bhatnagar, Neera ^a   Meade, Maureen ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b Centre Hospitalier Universitaire de Sherbrooke   (Canada)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Acute lung injury; Adrenal cortex hormones; Adult respiratory distress syndrome; Glucocorticoids; Infection; Mortality; Pneumonia; Steroids

Indexed keywords

CORTICOSTEROID; HYDROCORTISONE; METHYLPREDNISOLONE; PLACEBO; PREDNISOLONE;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CLINICAL TRIAL; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; HOSPITALIZATION; HUMAN; LOW DRUG DOSE; META ANALYSIS; MORTALITY; OUTCOME ASSESSMENT; PNEUMONIA; QUALITY OF LIFE; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TREATMENT RESPONSE;

EID: 80053255664     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2009.08.009     Document Type: Article

References (47)

1. Esteban A., Anzueto A., Frutos F., et al. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 2002, 287:345-355.
2. Estenssoro E., Dubin A., Laffaire E., et al. Incidence, clinical course, and outcome in 217 patients with acute respiratory distress syndrome. Crit Care Med 2002, 30:2450-2456.
3. Rubenfeld G.D., Herridge M.S. Epidemiology and outcomes of acute lung injury. Chest 2007, 131:554-562.
4. Hudson L.D., Milberg J.A., Anardi D., et al. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995, 151:293-301.
5. Hudson L.D., Steinberg K.P. Epidemiology of acute lung injury and ARDS. Chest 1999, 116:74S-82S.
6. Piantadosi C.A., Schwartz D.A. The acute respiratory distress syndrome. Ann Intern Med 2004, 141:460-470.
7. Monton C., Torres A., El-Ebiary M., et al. Cytokine expression in severe pneumonia: a bronchoalveolar lavage study. Crit Care Med 1999, 27:1745-1753. [see comment].
8. Puren A.J., Feldman C., Savage N., et al. Patterns of cytokine expression in community-acquired pneumonia. Chest 1995, 107:1342-1349.
9. Schutte H., Lohmeyer J., Rosseau S., et al. Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. Eur Respir J 1996, 9:1858-1867.
10. Kellum J.A., Kong L., Fink M.P., et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007, 167:1655-1663. [see comment].
11. Meduri G.U., Headley S., Kohler G., et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 1995, 107:1062-1073.
12. Bernard G.R., Artigas A., Brigham K.L., et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824.
13. The Acute Respiratory Distress Syndrome Network Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000, 342:1301-1308.
14. Brower R.G., Lanken P.N., MacIntyre N., et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004, 351:327-336.
15. Meade M.O., Cook D.J., Guyatt G.H., et al. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008, 299:637-645.
16. Mercat A., Richard J.C., Vielle B., et al. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008, 299:646-655.
17. Meduri G.U., Tolley E.A., Chrousos G.P., et al. Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids. Am J Respir Crit Care Med 2002, 165:983-991.
18. Rocco P.R., Souza A.B., Faffe D.S., et al. Effect of corticosteroid on lung parenchyma remodeling at an early phase of acute lung injury. Am J Respir Crit Care Med 2003, 168:677-684.
19. Annane D., Sebille V., Bellissant E. Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome. Crit Care Med 2006, 34:22-30.
20. Confalonieri M., Urbino R., Potena A., et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 2005, 171:242-248.
21. Meduri G.U., Golden E., Freire A.X., et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007, 131:954-963.
22. Meduri G.U., Headley A.S., Golden E., et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA 1998, 280:159-165.
23. Peter J.V., John P., Graham P.L., et al. Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ 2008, 336:1006-1009.
24. Meduri G.U., Marik P.E., Chrousos G.P., et al. Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med 2008, 34:61-69.
25. Lefebvre C., Manheimer E., Glanville J. Chapter 6: Searching for studies. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2008, Available from:. http://www.cochrane-handbook.org, J.P.T. Higgins, S. Green (Eds.).
26. Ferguson N.D., Kacmarek R.M., Chiche J.D., et al. Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial. Intensive Care Med 2004, 30:1111-1116.
27. Bassler D., Ferreira-Gonzalez I., Briel M., et al. Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol 2007, 60:869-873.
28. Montori V.M., Devereaux P.J., Adhikari N.K., et al. Randomized trials stopped early for benefit: a systematic review. JAMA 2005, 294:2203-2209.
29. Deeks J.J., Higgins J.P., Altman D.G. Chapter 9: Analyzing data and undertaking meta-analyses. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration 2008, Available from:. http://www.cochrane-handbook.org, J.P.T. Higgins, S. Green (Eds.).
30. Sterne J.A., Egger M., Smith G.D. Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. BMJ 2001, 323:101-105.
31. Guyatt G.H., Wyer P., Ioannidis J. When to believe a subgroup analysis. User's Guides to the medical literature: a manual for evidence-based clinical practice 2008, The McGraw Hill Companies Inc. G. Guyatt, M.O. Meade, D. Rennie, J.D. Cook (Eds.).
32. Altman D.G., Bland J.M. Interaction revisited: the difference between two estimates. BMJ 2003, 326:219.
33. Guyatt G.H., Oxman A.D., Kunz R., et al. What is "quality of evidence" and why is it important to clinicians?. BMJ 2008, 336:995-998.
34. Guyatt G.H., Oxman A.D., Vist G.E., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008, 336:924-926.
35. Mikami K., Suzuki M., Kitagawa H., et al. Efficacy of corticosteroids in the treatment of community-acquired pneumonia requiring hospitalization. Lung 2007, 185:249-255.
36. Schein R.M., Bergman R., Marcial E.H., et al. Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. Chest 1987, 91:850-854.
37. Marik P., Kraus P., Sribante J., et al. Hydrocortisone and tumor necrosis factor in severe community-acquired pneumonia. A randomized controlled study. Chest 1993, 104:389-392.
38. Steinberg K.P., Hudson L.D., Goodman R.B., et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006, 354:1671-1684.
39. McHardy V.U., Schonell M.E. Ampicillin dosage and use of prednisolone in treatment of pneumonia: co-operative controlled trial. Br Med J 1972, 4:569-573.
40. Wagner H.N., Bennett I.L., Lasagna L., et al. The effect of hydrocortisone upon the course of pneumococcal pneumonia treated with penicillin. Bull Johns Hopkins Hosp 1956, 98:197-215.
41. Laggner A.N., Lenz K., Base W., et al. Effect of high-dose prednisolone on lung fluid in patients with non-cardiogenic lung edema. Wien Klin Wochenschr 1987, 99:245-249.
42. Weigelt J.A., Norcross J.F., Borman K.R., et al. Early steroid therapy for respiratory failure. Arch Surg 1985, 120:536-540.
43. Bernard G.R., Luce J.M., Sprung C.L., et al. High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med 1987, 317:1565-1570.
44. Annane D., Bellissant E., Bollaert P.E., et al. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004, 329:480.
45. Marik P.E., Pastores S.M., Annane D., et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008, 36:1937-1949. [see comment].
46. Agarwal R., Nath A., Aggarwal A.N., et al. Do glucocorticoids decrease mortality in acute respiratory distress syndrome? A meta-analysis. Respirology 2007, 12:585-590.
47. Tang B.M., Craig J.C., Eslick G.D., et al. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 2009, 37:1594-1603. [see comment].