The role of serotonin in viral hepatitis - Depletion of plasma tryptophan as a potential option to reduce virus persistence and immunopathology?

Medical Hypotheses

Volumn 72, Issue 3, 2009, Pages 367-

  Zepf, Florian Daniel ^a   Holtmann, Martin ^a   Poustka, Fritz ^a   Wöckel, Lars ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; SEROTONIN; TRYPTOPHAN;

ACTIVE TRANSPORT; AMINO ACID BLOOD LEVEL; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ATTENTION DEFICIT DISORDER; BLOOD BRAIN BARRIER; BODY WEIGHT; CD8+ T LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; DRUG TOLERABILITY; HUMAN; IMMUNOPATHOLOGY; LETTER; LIVER; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NAUSEA AND VOMITING; PERSISTENT VIRUS INFECTION; PRECURSOR; PRIORITY JOURNAL; PROTEIN SYNTHESIS; THROMBOCYTE; VIRUS HEPATITIS;

ANIMALS; BLOOD PLATELETS; CD8-POSITIVE T-LYMPHOCYTES; HALF-LIFE; HEPATITIS, VIRAL, ANIMAL; LIVER; LYMPHOCYTIC CHORIOMENINGITIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; PLATELET COUNT; SEROTONIN; TRYPTOPHAN;

EID: 59249084005     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.09.035     Document Type: Letter

References (8)

1. Lang P.A., et al. Aggravation of viral hepatitis by platelet-derived serotonin. Nature Med 14 (2008) 756-761
2. Moja E.A., et al. Decrease in plasma tryptophan after tryptophan-free amino acid mixtures in man. Life Sci 42 16 (1988) 1551-1556
3. Zepf F.D., Holtmann M., Stadler C., Schmitt M., and Poustka F. Diminished serotonergic functioning in hostile children with ADHD: tryptophan depletion increases behavioural inhibition. Pharmacopsychiatry 41 2 (2008) 60-65
4. Zepf F.D., Wöckel L., Poustka F., and Holtmann M. Diminished 5-HT functioning in CBCL pediatric bipolar disorder profiled ADHD patients vs normal ADHD: susceptibility to rapid tryptophan depletion influences reaction time performance. Human Psychopharmacol Clin Exp 23 4 (2008) 291-299
5. Zepf F.D., Stadler C., Demisch L., Schmitt M., Landgraf M., and Poustka F. Serotonergic functioning and trait-impulsivity in attention-deficit/hyperactivity-disordered boys (ADHD): influence of rapid tryptophan depletion. Human Psychopharmacol Clin Exp 23 1 (2008) 43-51
6. Moore P., et al. Clinical and physiological consequences of rapid tryptophan depletion. Neuropsychopharmacology 23 6 (2002) 601-622
7. Kewitz A. Biochemische Untersuchungen zur Optimierung des »Rapid tryptophan depletion-test« (RTD): Eine physiologische Methode zur akuten Vermidnerung der zentralnervösen Serotonin-Synthese in der psychobiologischen Forschung. Medizinische Dissertationsarbeit, J. W. Goethe Universität, Frankfurt am Main; 2002.
8. Zepf FD, Holtmann M, Wöckel L, Poustka F. Dietary tryptophan depletion according to body weight - a new treatment option in acute mania? Med Hypotheses; in press, doi:10.1016/j.mehy.2008.06.046.