Serotonergic functioning and trait-impulsivity in attention-deficit/hyperactivity-disordered boys (ADHD): Influence of rapid tryptophan depletion

Human Psychopharmacology

Volumn 23, Issue 1, 2008, Pages 43-51

  Zepf, Florian Daniel ^a   Stadler, Christina ^a   Demisch, Lothar ^a   Schmitt, Marcus ^a   Landgraf, Meike ^a   Poustka, Fritz ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

ADHD; Aggression; Impulsivity; RTD; Serotonin; Tryptophan

Indexed keywords

AMINO ACID MIXTURE; METHYLPHENIDATE; PLACEBO; SEROTONIN; TRYPTOPHAN;

ADOLESCENT; AGGRESSION; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN LEVEL; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; GENDER; HUMAN; IMPULSIVENESS; INTERNATIONAL CLASSIFICATION OF DISEASES; MALE; NEUROCHEMISTRY; PERSONALITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; RAPID TRYPTOPHAN DEPLETION; REACTION TIME; SCHOOL CHILD; SEROTONIN RELEASE; SEROTONINERGIC TRANSMISSION;

AGGRESSION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CROSS-OVER STUDIES; DIET, REDUCING; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; HUMANS; IMPULSIVE BEHAVIOR; MALE; PSYCHIATRIC STATUS RATING SCALES; REACTION TIME; SEROTONIN; TRYPTOPHAN;

EID: 38649125257     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.896     Document Type: Article

References (57)

1. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders: American Psychiatric Association. American Psychiatric Press: Washington, DC.
2. Barkley RA. 1998. Attention Deficit Hyperactivity Disorder; a Handbook for Diagnosis and Treatment. Guilford Press: New York.
3. Beitchman J, Davidge KM, Kennedy JL, et al. 2003. The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls. Ann N Y Acad Sci 1008: 248-251.
4. Biederman J. 2005. Attention-Deficit/Hyperactivity disorder: a selective overview. Biol Psychiatry 57: 1215-1220.
5. Biederman J, Newcorn J, Sprich S. 1991. Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry 148: 564-577.
6. Biederman J, Mick E, Faraone SV, et al. 2002. Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. Am J Psychiatry 159: 36-42.
7. Buss AH, Perry M. 1992. The aggression questionnaire. J Pers Soc Psychol 63: 452-459.
8. Cadoret RJ, Langbehn D, Caspers K, et al. 2003. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Compr Psychiatry 44: 88-101.
9. Castellanos FX, Elia J, Kruesi MJP, et al. 1994. Cerebrospinal fluid monoamine metabolites in boys with attention-deficit-hyperactivity disorder. Psychiatry Res 52: 306-316.
10. Castellanos FX, Giedd JN, Marsh WL, et al. 1996. Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry 53: 607-616.
11. Coccaro EF, Bergeman CS, McClearn GE. 1993. Heritability of irritable impulsiveness: a study of twins reared together and apart. Psychiatry Res 48: 229-242.
12. Coccaro EF, Kavoussi RJ, Cooper TB, Hauger R. 1998. Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects. Psychopharmacology (Berl) 138: 9-15.
13. Demisch L, Kewitz A, Schmeck K, et al. 2002. Methodology of rapid tryptophan depletion (RTD): impact of gender and body weight. Eur Arch Psychiatry Clin Neurosci 252 (Supplement 2): I/25.
14. Demisch L, Zepf F, Schmitt M, et al. 2004. Experimentally induced reduction of central serotonin synthesis by using the "Rapid Tryptophan Depletion-Test" (RTD) in accordance with Moja et al.: methodology, development and application in children and adolescents Presented at the "12th annual meeting on Biological Child and Adolescent Psychiatry", Goettingen (Germany).
15. Elia J, Ambrosini PJ, Rapoport JL. 1999. Treatment of attention-deficit-hyperactivity disorder. N Engl J Med 340: 780-788.
16. Fairbanks LA, Fontenot MB, Phillips-Conroy JE, Jolly CJ, Kaplan JR, Mann JJ. 1999. CSF monoamines, age and impulsivity in wild Grivet monkeys (Cercopithecus aethiops aethiops). Brain Behav Evol 53: 305-312.
17. Faraone SV, Biederman J. 1998. Neurobiology of attention deficit hyperactivity disorder. Biol Psychiatry 44: 951-958.
18. Farrington DP. 1995. The twelfth Jack Tizard memorial lecture. The development of offending and antisocial behavior from childhood: key findings from the Cambridge Study in Delinquent Development. J Child Psychol Psychiatry 36: 929-964.
19. Halperin JM, Sharma V, Schwartz ST, Matier K, Wornell G, Newcorn JH. 1994. Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Am J Psychiatry 151: 243-248.
20. Halperin JM, Newcorn JH, Matier K, Bedi G, Hall S, Sharma V. 1995. Impulsivity and the initiation of fights in children with disruptive behavior disorders. J Child Psychol Psychiatry 36: 1199-1211.
21. Halperin JM, Newcorn JH, Schwartz ST, et al. 1997. Age-related changes in the association between serotonergic function and aggression in boys with ADHD. Biol Psychiatry 41: 682-689.
22. Hawi Z, Dring M, Kirley A, et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Mol Psychiatry 7: 718-725.
23. Hodapp V. 2001. Fragebogen zum Umgang mit anderen Personen (AQ-G) Johann Wolfgang Goethe Universität/Fachbereich Psychologie/Abteilung Differentielle Psychologie und Psychologische Diagnostik, Frankfurt/Main.
24. Kagan J, Zentner M. 1996. Early childhood predictors of adult psychopathology. Harv Rev Psychiatry 3/6: 341-350.
25. Kent L, Doerry U, Hardy E, et al. 2002. Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. Mol Psychiatry 7: 908-912.
26. Kewitz A. 2002. Biochemische Untersuchungen zur Optimierung des "Rapid Tryptophan Depletion-Test" (RTD): Eine physiologische Methode zur akuten Vermidnerung der zentralnervösen Scrotonin-Synthese in der psychobiologischen Forschung Medizinische Dissertationsarbeit, J.W. Goethe Universität, Frankfurt am Main.
27. Kruesi MJP, Rapoport JL, Hamburger S, et al. 1990. Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 47: 419-426.
28. Kruesi MJP, Hibbs ED, Zahn TP, et al. 1992. A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders: prediction by cerebrospinal fluid 5-Hydroxy-indoleacetic acid, homovanillic acid and autonomic measures. Arch Gen Psychiatry 49: 429-435.
29. Langley K, Payton A, Hamshere ML, et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatr Genet 13: 107-110.
30. Lyons MJ, True WR, Eisen SA, et al. 1995. Differential heritability of adult and juvenile antisocial traits. Arch Gen Psychiatry 52: 906-915.
31. Maes M, Meltzer HY. 2000. The Serotonin Hypothesis of Major Depression. In Psychopharmacology: The Fourth Generation of Progress. Raven Press: New York.
32. Manor I, Eisenberg J, Tyano S, et al. 2001. Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. Am J Med Genet 105: 91-95.
33. Moja EA, Stoff DM, Gessa GL, Castoldi D, Assereto R, Tofanetti O. 1988. Decrease in plasma tryptophan after tryptophan-free amino acid mixtures in man. Life Sci 42: 1551-1556.
34. Moore P, Landolt HP, Seifritz E, et al. 2000. Clinical and physiological consequences of rapid tryptophan depletion. Neuropsychopharmacology 23: 601-622.
35. Muris R Meesters C. 2003. The validity of attention deficit hyper-activity disorder and hyperkinetic disorder symptom domains in nonclinical Dutch children. J Clin Child Adolesc Psychol 32: 460-466.
36. Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJS. 2005. Causal models in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 57: 1224-1230.
37. Pedersen NL, Plomon R, McClearn GE, Friberg L. 1988. Neuroticism, extraversion and related traits in adults twins reared apart and reared together. J Pers Soc Psychol 55: 950-957.
38. Pelham WE, Milich R, Cummings EM, Murphy DA, Schaughency EA, Greiner AR. 1991. Effects of background anger, provocation, and methylphenidate on emotional arousal and aggressive responding in attention-deficit hyperactivity disordered boys with and without concurrent aggressiveness. J Abnorm Child Psychol 19: 407-426.
39. Pennington B. 2005. Toward a new neuropsychological model of attention-deficit/hyperactivity disorder: subtypes and multiple deficits. Biol Psychiatry 57: 1221-1223.
40. Pine DS, Coplan JD, Wasserman GA, et al. 1997. Neuroendocrine response to fenfluramine challenge in boys. Arch Gen Psychiatry 54: 839-846.
41. Pliszka SR. 1998. Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorder: an overview. J Clin Psychiatry 59: 50-59.
42. Quist JF, Barr CL, Schachar R, et al. 2003. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Mol Psychiatry 8: 98-102.
43. Retz W, Rosler M, Supprian T, Retz-Junginger P, Thome J. 2003. Dopamine D3 receptor gene polymorphism and violent behavior. Relation to impulsiveness and ADHD-related psychopathology. J Neural Transm 110: 561-572.
44. Schulz KP, Newcorn JH, McKay KE, et al. 2001. Relationship between central serotonergic function and aggression in prepubertal boys: effect of age and attention-deficit/hyperactivity disorder. Psychiatry Res 101: 1-10.
45. Seroczynski AD, Bergeman CS, Coccaro EF. 1999. Etiology of the impulsivity aggression relationship: genes or environment? Psychiatry Res 86: 41-57.
46. Shemer AV, Azmitia EC, Whitaker-Azmitia PM. 1991. Dose-related effects of prenatal 5-methoxytryptamine (5-MT) on development of serotonin terminal density and behavior. Brain Res Dev Brain Res 59: 59-63.
47. Stadler C, Janke W. 2002. Concurrent validity of the German version of S.B. Eysenck's impulsiveness questionnaire for children. Pers Individ Dif 35: 51-58.
48. Stadler C, Zepf FD, Demisch L, Schmitt M, Landgraf M, Poustka F. in press. Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD. Neuropsychobiology.
49. Stefan EL. 2004. Entwicklung und Validierung der deutschen Version des Aggressionsfiragebogens (AG-G). Unveröffentlichte Diplomarbeit, Institut für Psychologie, Frankfurt am Main, J.W. Goethe-Universität.
50. Stein DJ, Hollander E, Liebowitz MR. 1993. Neurobiology of impulsivity and the impulse control disorders. J Neuropsychiatr 5: 9-17.
51. Stoff DM, Pasatiempo AP, Yeung JH, Cooper TB, Bridget WH, Rabinovich H. 1992. Neuroendocrine response to challenge with D,L-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Res 43: 263-276.
52. Vitiello B, Stoff DM. 1997. Subtypes of aggression and their relevance to child psychiatry. J Am Acad Child Adolesc Psychiatry 36: 307-315.
53. Waschbusch DA, Pelham WE, Jennings JR, Greiner AR, Tarter RE, Moss HB. 2002. Reactive aggression in boys with disruptive behavior disorders: behavior, physiology and affect. J Abnorm Child Psychol 30: 641-656.
54. Whitaker-Azmitia PM, Zhang X, Clarke C. 1994. Effects of gestational exposure to monoamine oxidase inhibitors in rats: Preliminary behavioral and neurochemical studies. Neuropsychopharmacology 11: 125-132.
55. White JL, Moffit TE, Caspi A, Bartusch Dj, Needles DJ, Strouthamer-Loeber M. 1994. Measuring impulsivity and examining its relationship to delinquency. J Abnorm Child Psychol 103/2: 192-205.
56. Young SN, Smith SE, Pihl RO, Ervin FR. 1985. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology (Berl) 87: 173-177.
57. Zoroglu SS, Erdal ME, Alasehirli B, et al. 2002. Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder. Neuropsychobiology 45: 176-181.