The E3 ubiquitin ligase TRIM11 mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B

Journal of Molecular Medicine

Volumn 90, Issue 9, 2012, Pages 1025-1035

  Parodi, Sara ^a,b   Di Zanni, Eleonora ^a   Di Lascio, Simona ^c   Bocca, Paola ^a   Prigione, Ignazia ^a   Fornasari, Diego ^c   Pennuto, Maria ^b   Bachetti, Tiziana ^a   Ceccherini, Isabella ^a  

^a G GASLINI INSTITUTE   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Aggregation; Congenital central hypoventilation syndrome; E3 ubiquitin ligase; Insoluble fraction; PHOX2B; Polyalanine expansion; Ubiquitin proteasome system

Indexed keywords

ALANINE; MUTANT PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PHOX2B; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE TRIM11; UNCLASSIFIED DRUG;

ARTICLE; CONGENITAL CENTRAL HYPOVENTILATION SYNDROME; CONTROLLED STUDY; CORRELATION COEFFICIENT; GENE TARGETING; HUMAN; HUMAN TISSUE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; PROTEIN FOLDING; REGULATORY MECHANISM; UBIQUITINATION; WESTERN BLOTTING;

CELL LINE, TUMOR; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; HYPOVENTILATION; MUTANT PROTEINS; MUTATION; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; SLEEP APNEA, CENTRAL; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84867334353     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0868-1     Document Type: Article

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