메뉴 건너뛰기




Volumn 1482, Issue , 2012, Pages 13-21

Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway

Author keywords

Amyloid beta; Antioxidant; ERK1 2; Gastrodin; Nrf2

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CATALASE; GASTRODIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENT; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

EID: 84867329289     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.09.010     Document Type: Article
Times cited : (98)

References (48)
  • 1
    • 61749103704 scopus 로고    scopus 로고
    • Protective effect of quercetin in primary neurons against Abeta(1-42): Relevance to Alzheimer's disease
    • M.A. Ansari, H.M. Abdul, G. Joshi, W.O. Opii, and D.A. Butterfield Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease J. Nutr. Biochem. 20 2009 269 275
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 269-275
    • Ansari, M.A.1    Abdul, H.M.2    Joshi, G.3    Opii, W.O.4    Butterfield, D.A.5
  • 2
    • 34249307785 scopus 로고    scopus 로고
    • MAPK activation in the hippocampus in vivo is correlated with experimental setting
    • K. Belelovsky, M. Maroun, and K. Rosenblum MAPK activation in the hippocampus in vivo is correlated with experimental setting Neurobiol. Learn Mem. 88 2007 58 64
    • (2007) Neurobiol. Learn Mem. , vol.88 , pp. 58-64
    • Belelovsky, K.1    Maroun, M.2    Rosenblum, K.3
  • 3
    • 0034833908 scopus 로고    scopus 로고
    • Oxidative and hydrolytic properties of beta-amyloid
    • M. Brzyska, A. Bacia, and D. Elbaum Oxidative and hydrolytic properties of beta-amyloid Eur. J. Biochem. 268 2001 3443 3454
    • (2001) Eur. J. Biochem. , vol.268 , pp. 3443-3454
    • Brzyska, M.1    Bacia, A.2    Elbaum, D.3
  • 4
    • 77953537275 scopus 로고    scopus 로고
    • Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning
    • G. Bureau, M. Carrier, M. Lebel, and M. Cyr Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning Neurobiol. Learn Mem. 94 2010 107 115
    • (2010) Neurobiol. Learn Mem. , vol.94 , pp. 107-115
    • Bureau, G.1    Carrier, M.2    Lebel, M.3    Cyr, M.4
  • 7
    • 80455134786 scopus 로고    scopus 로고
    • Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats
    • B.O. Cho, H.W. Ryu, C.H. Jin, D.S. Choi, S.Y. Kang, D.S. Kim, M.W. Byun, and I.Y. Jeong Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats J. Agric. Food Chem. 59 2011 11442 11448
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 11442-11448
    • Cho, B.O.1    Ryu, H.W.2    Jin, C.H.3    Choi, D.S.4    Kang, S.Y.5    Kim, D.S.6    Byun, M.W.7    Jeong, I.Y.8
  • 8
    • 33745985711 scopus 로고    scopus 로고
    • ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    • Y.H. Chong, Y.J. Shin, E.O. Lee, R. Kayed, C.G. Glabe, and A.J. Tenner ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures J. Biol. Chem. 281 2006 20315 20325
    • (2006) J. Biol. Chem. , vol.281 , pp. 20315-20325
    • Chong, Y.H.1    Shin, Y.J.2    Lee, E.O.3    Kayed, R.4    Glabe, C.G.5    Tenner, A.J.6
  • 9
    • 0035875962 scopus 로고    scopus 로고
    • Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
    • K.T. Dineley, M. Westerman, D. Bui, K. Bell, K.H. Ashe, and J.D. Sweatt Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease J. Neurosci. 21 2001 4125 4133
    • (2001) J. Neurosci. , vol.21 , pp. 4125-4133
    • Dineley, K.T.1    Westerman, M.2    Bui, D.3    Bell, K.4    Ashe, K.H.5    Sweatt, J.D.6
  • 10
    • 27844525476 scopus 로고    scopus 로고
    • Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure
    • V. Echeverria, A. Clerman, and S. Doré Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure Eur. J. Neurosci. 22 2005 2199 2206
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 2199-2206
    • Echeverria, V.1    Clerman, A.2    Doré, S.3
  • 11
    • 75149149368 scopus 로고    scopus 로고
    • Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer′s disease after chronic exposure to aluminum
    • T. Garcia, J.L. Esparza, M.R. Nogués, M. Romeu, J.L. Domingo, and M. Gómez Oxidative stress status and RNA expression in hippocampus of an animal model of Alzheimer′s disease after chronic exposure to aluminum Hippocampus 20 2010 218 225
    • (2010) Hippocampus , vol.20 , pp. 218-225
    • Garcia, T.1    Esparza, J.L.2    Nogués, M.R.3    Romeu, M.4    Domingo, J.L.5    Gómez, M.6
  • 12
    • 56949092261 scopus 로고    scopus 로고
    • Does salicylic acid regulate antioxidant defense system, cell death, cadmium uptake and partitioning to acquire cadmium tolerance in rice
    • B. Guo, Y. Liang, and Y. Zhu Does salicylic acid regulate antioxidant defense system, cell death, cadmium uptake and partitioning to acquire cadmium tolerance in rice J. Plant. Physiol. 166 2009 20 31
    • (2009) J. Plant. Physiol. , vol.166 , pp. 20-31
    • Guo, B.1    Liang, Y.2    Zhu, Y.3
  • 13
    • 78649820608 scopus 로고    scopus 로고
    • Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity
    • L.K. Habib, M.T. Lee, and J. Yang Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity J. Biol. Chem. 285 2010 38933 38943
    • (2010) J. Biol. Chem. , vol.285 , pp. 38933-38943
    • Habib, L.K.1    Lee, M.T.2    Yang, J.3
  • 14
    • 44249109772 scopus 로고    scopus 로고
    • Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats
    • A.M. Haque, M. Hashimoto, M. Katakura, Y. Hara, and O. Shido Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats J. Nutr. Biochem. 19 2008 619 626
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 619-626
    • Haque, A.M.1    Hashimoto, M.2    Katakura, M.3    Hara, Y.4    Shido, O.5
  • 16
    • 61449134946 scopus 로고    scopus 로고
    • Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
    • S. Kalayarasan, P.N. Prabhu, N. Sriram, R. Manikandan, M. Arumugam, and G. Sudhandiran Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats Eur. J. Pharmacol. 606 2009 162 171
    • (2009) Eur. J. Pharmacol. , vol.606 , pp. 162-171
    • Kalayarasan, S.1    Prabhu, P.N.2    Sriram, N.3    Manikandan, R.4    Arumugam, M.5    Sudhandiran, G.6
  • 17
    • 0034613438 scopus 로고    scopus 로고
    • Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations
    • S. Leutner, C. Czech, K. Schindowski, N. Touchet, A. Eckert, and W.E. Müller Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations Neurosci. Lett. 292 2000 87 90
    • (2000) Neurosci. Lett. , vol.292 , pp. 87-90
    • Leutner, S.1    Czech, C.2    Schindowski, K.3    Touchet, N.4    Eckert, A.5    Müller, W.E.6
  • 18
    • 70450217248 scopus 로고    scopus 로고
    • Clock test deficits are associated with semantic memory impairment in Alzheimer disease
    • T. Leyhe, R. Saur, G.W. Eschweiler, and M. Milian Clock test deficits are associated with semantic memory impairment in Alzheimer disease J. Geriatr. Psychiatry Neurol. 22 2009 235 245
    • (2009) J. Geriatr. Psychiatry Neurol. , vol.22 , pp. 235-245
    • Leyhe, T.1    Saur, R.2    Eschweiler, G.W.3    Milian, M.4
  • 19
    • 79953771772 scopus 로고    scopus 로고
    • Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: The role of Nrf2 and antioxidant enzymes
    • L. Li, W. Li, S.W. Jung, Y.W. Lee, and Y.H. Kim Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes Biosci. Biotechnol. Biochem. 75 2011 434 442
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , pp. 434-442
    • Li, L.1    Li, W.2    Jung, S.W.3    Lee, Y.W.4    Kim, Y.H.5
  • 20
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 21
    • 77952888677 scopus 로고    scopus 로고
    • Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells
    • W. Ma, L. Yuan, H. Yu, B. Ding, Y. Xi, J. Feng, and R. Xiao Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells Int. J. Dev. Neurosci. 28 2010 289 295
    • (2010) Int. J. Dev. Neurosci. , vol.28 , pp. 289-295
    • Ma, W.1    Yuan, L.2    Yu, H.3    Ding, B.4    Xi, Y.5    Feng, J.6    Xiao, R.7
  • 22
    • 69449096141 scopus 로고    scopus 로고
    • Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease
    • C.A. Massaad, T.M. Washington, R.G. Pautler, and E. Klann Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A 106 2009 13576 13581
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 13576-13581
    • Massaad, C.A.1    Washington, T.M.2    Pautler, R.G.3    Klann, E.4
  • 23
    • 10844277858 scopus 로고    scopus 로고
    • Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment
    • S. Melov, N. Wolf, D. Strozyk, S.R. Doctrow, and A.I. Bush Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment Free Radical Biol. Med. 38 2005 258 261
    • (2005) Free Radical Biol. Med. , vol.38 , pp. 258-261
    • Melov, S.1    Wolf, N.2    Strozyk, D.3    Doctrow, S.R.4    Bush, A.I.5
  • 25
    • 33645106304 scopus 로고    scopus 로고
    • Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: Implications for Alzheimer's disease
    • H. Mohmmad Abdul, R. Sultana, J.N. Keller, D.K. St Clair, W.R. Markesbery, and D.A. Butterfield Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease J. Neurochem. 96 2006 1322 1335
    • (2006) J. Neurochem. , vol.96 , pp. 1322-1335
    • Mohmmad Abdul, H.1    Sultana, R.2    Keller, J.N.3    St Clair, D.K.4    Markesbery, W.R.5    Butterfield, D.A.6
  • 26
    • 79957935370 scopus 로고    scopus 로고
    • Assessment of antioxidant capacity of natural products
    • E. Niki Assessment of antioxidant capacity of natural products Curr. Pharm. Biotechnol. 11 2010 801 809
    • (2010) Curr. Pharm. Biotechnol. , vol.11 , pp. 801-809
    • Niki, E.1
  • 28
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • H. Oakley, S.L. Cole, S. Logan, E. Maus, P. Shao, J. Craft, A. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, L. Van Eldik, R. Berry, and R. Vassar Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation J. Neurosci. 26 2006 10129 10140
    • (2006) J. Neurosci. , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 29
    • 57749120460 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    • M. Ohtsuji, F. Katsuoka, A. Kobayashi, H. Aburatani, J.D. Hayes, and M. Yamamoto Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes J. Biol. Chem. 283 2008 33554 33562
    • (2008) J. Biol. Chem. , vol.283 , pp. 33554-33562
    • Ohtsuji, M.1    Katsuoka, F.2    Kobayashi, A.3    Aburatani, H.4    Hayes, J.D.5    Yamamoto, M.6
  • 30
    • 4744360664 scopus 로고    scopus 로고
    • NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells
    • S. Papaiahgari, S.R. Kleeberger, H.Y. Cho, D.V. Kalvakolanu, and S.P. Reddy NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells J. Biol. Chem. 279 2004 42302 42312
    • (2004) J. Biol. Chem. , vol.279 , pp. 42302-42312
    • Papaiahgari, S.1    Kleeberger, S.R.2    Cho, H.Y.3    Kalvakolanu, D.V.4    Reddy, S.P.5
  • 32
    • 77957221943 scopus 로고    scopus 로고
    • Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN. Invest
    • I. Pitha-Rowe, K. Liby, D. Royce, and M. Sporn Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN. Invest Ophthalmol. Vis. Sci. 50 2009 5339 5347
    • (2009) Ophthalmol. Vis. Sci. , vol.50 , pp. 5339-5347
    • Pitha-Rowe, I.1    Liby, K.2    Royce, D.3    Sporn, M.4
  • 35
    • 2542418930 scopus 로고    scopus 로고
    • Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein
    • G. Shen, V. Hebbar, S. Nair, C. Xu, W. Li, W. Lin, Y.S. Keum, J. Han, M.A. Gallo, and A.N. Kong Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein J. Biol. Chem. 279 2004 23052 23060
    • (2004) J. Biol. Chem. , vol.279 , pp. 23052-23060
    • Shen, G.1    Hebbar, V.2    Nair, S.3    Xu, C.4    Li, W.5    Lin, W.6    Keum, Y.S.7    Han, J.8    Gallo, M.A.9    Kong, A.N.10
  • 36
    • 77149166322 scopus 로고    scopus 로고
    • Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice
    • Y.Q. Shi, T.W. Huang, L.M. Chen, X.D. Pan, J. Zhang, Y.G. Zhu, and X.C. Chen Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice J. Alzheimers Dis. 19 2010 977 989
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 977-989
    • Shi, Y.Q.1    Huang, T.W.2    Chen, L.M.3    Pan, X.D.4    Zhang, J.5    Zhu, Y.G.6    Chen, X.C.7
  • 38
    • 79961210010 scopus 로고    scopus 로고
    • ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression
    • C. Su, W. Underwood, N. Rybalchenko, and M. Singh ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression J. Neurosci. Res. 89 2011 1542 1550
    • (2011) J. Neurosci. Res. , vol.89 , pp. 1542-1550
    • Su, C.1    Underwood, W.2    Rybalchenko, N.3    Singh, M.4
  • 39
    • 71249160483 scopus 로고    scopus 로고
    • Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia
    • I. Szaingurten-Solod-kin, N. Hadad, and R. Levy Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia Glia 57 2009 1727 1740
    • (2009) Glia , vol.57 , pp. 1727-1740
    • Szaingurten-Solod-Kin, I.1    Hadad, N.2    Levy, R.3
  • 40
    • 77954621176 scopus 로고    scopus 로고
    • Attenuation of NF-kappaB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis
    • S.K. Tusi, N. Ansari, M. Amini, A.D. Amirabad, A. Shafiee, and F. Khodagholi Attenuation of NF-kappaB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis Apoptosis 15 2010 738 751
    • (2010) Apoptosis , vol.15 , pp. 738-751
    • Tusi, S.K.1    Ansari, N.2    Amini, M.3    Amirabad, A.D.4    Shafiee, A.5    Khodagholi, F.6
  • 41
    • 78650685650 scopus 로고    scopus 로고
    • β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and caenorhabditis elegans models of Alzheimer disease
    • L. Wan, G. Nie, J. Zhang, Y. Luo, P. Zhang, Z. Zhang, and B. Zhao β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and caenorhabditis elegans models of Alzheimer disease Free Radical Biol. Med. 50 2011 122 129
    • (2011) Free Radical Biol. Med. , vol.50 , pp. 122-129
    • Wan, L.1    Nie, G.2    Zhang, J.3    Luo, Y.4    Zhang, P.5    Zhang, Z.6    Zhao, B.7
  • 42
    • 37749014296 scopus 로고    scopus 로고
    • Distribution and metabolism of gastrodin in rat brain
    • Q. Wang, G. Chen, and S. Zeng Distribution and metabolism of gastrodin in rat brain J. Pharm. Biomed. Anal. 46 2008 399 404
    • (2008) J. Pharm. Biomed. Anal. , vol.46 , pp. 399-404
    • Wang, Q.1    Chen, G.2    Zeng, S.3
  • 43
    • 17444427161 scopus 로고    scopus 로고
    • Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neurons
    • Y. Watanabe, N. Matsumoto, M. Dezawa, Y. Itokazu, T. Yoshihara, and C. Ide Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neurons Neurosci. Lett. 379 2005 158 163
    • (2005) Neurosci. Lett. , vol.379 , pp. 158-163
    • Watanabe, Y.1    Matsumoto, N.2    Dezawa, M.3    Itokazu, Y.4    Yoshihara, T.5    Ide, C.6
  • 44
    • 34447531020 scopus 로고    scopus 로고
    • Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons
    • X. Xu, Y. Lu, and X. Bie Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons Planta Med. 73 2007 650 654
    • (2007) Planta Med. , vol.73 , pp. 650-654
    • Xu, X.1    Lu, Y.2    Bie, X.3
  • 45
    • 77956884328 scopus 로고    scopus 로고
    • The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage
    • X. Xu, F. Martin, and J.S. Friedman The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage Blood Cells Mol. Dis. 45 2010 227 232
    • (2010) Blood Cells Mol. Dis. , vol.45 , pp. 227-232
    • Xu, X.1    Martin, F.2    Friedman, J.S.3
  • 46
    • 70349952431 scopus 로고    scopus 로고
    • Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor
    • K.F. Young, S.H. Pasternak, and R.J. Rylett Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor Neurochem. Int. 55 2009 796 801
    • (2009) Neurochem. Int. , vol.55 , pp. 796-801
    • Young, K.F.1    Pasternak, S.H.2    Rylett, R.J.3
  • 47
    • 77958014684 scopus 로고    scopus 로고
    • Enzymic synthesis of gastrodin through microbial transformation and purification of gastrodin biosynthesis enzyme
    • H. Zhu, P. Dai, W. Zhang, E. Chen, W. Han, C. Chen, and Y. Cui Enzymic synthesis of gastrodin through microbial transformation and purification of gastrodin biosynthesis enzyme Biol. Pharm. Bull. 33 2010 1680 1684
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 1680-1684
    • Zhu, H.1    Dai, P.2    Zhang, W.3    Chen, E.4    Han, W.5    Chen, C.6    Cui, Y.7
  • 48
    • 33846187694 scopus 로고    scopus 로고
    • ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells
    • S. Zhuang, Y. Yan, R.A. Daubert, J. Han, and R.G. Schnellmann ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells Am. J. Physiol. Renal. Physiol. 292 2007 440 447
    • (2007) Am. J. Physiol. Renal. Physiol. , vol.292 , pp. 440-447
    • Zhuang, S.1    Yan, Y.2    Daubert, R.A.3    Han, J.4    Schnellmann, R.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.