Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 21, 2011, Pages 11442-11448

  Cho, Byoung Ok ^a   Ryu, Hyung Won ^a   Jin, Chang Hyun ^a   Choi, Dae Seong ^a   Kang, Si Yong ^a   Kim, Dong Sub ^a   Byun, Myung Woo ^b   Jeong, Il Yun ^a  

^a Korea Atomic Energy Research Institute   (South Korea)

^b Woosong University   (South Korea)

Author keywords

antioxidant enzyme; blackberry; carbon tetrachloride; lipid peroxidation; NF E2 related factor 2 (Nrf2); oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT ENZYME; ASPARTATE AMINOTRANSFERASE; BLACKBERRY; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEME OXYGENASE-1; IN-VIVO; LIPID PEROXIDATION; NF-E2-RELATED FACTOR-2 (NRF2); PROTECTIVE EFFECTS; PROTEIN EXPRESSION LEVELS; SUPEROXIDE DISMUTASES; UP-REGULATION;

AMINO ACIDS; CARBON TETRACHLORIDE; CATALYSTS; ENZYMES; OXIDATION; OXYGEN; PORPHYRINS; RATS;

OXIDATIVE STRESS;

ANTIOXIDANT; CARBON TETRACHLORIDE; CATALASE; GLUTATHIONE PEROXIDASE; PLANT EXTRACT; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ARTICLE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; LIVER; MALE; METABOLISM; OXIDATIVE STRESS; RAT; ROSACEAE; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS; UPREGULATION;

ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE; CATALASE; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; GLUTATHIONE PEROXIDASE; HUMANS; LIVER; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; ROSACEAE; SUPEROXIDE DISMUTASE; UP-REGULATION;

RATTUS; RUBUS;

EID: 80455134786     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf2021804     Document Type: Article

References (32)

1. Kaspar, J. W.; Niture, S. K.; Jaiswal, A. K. Nrf2:INrf2 (Keap1) signaling in oxidative stress Free Radical Biol. Med. 2009, 47, 1304-1309
2. Wiseman, H.; Halliwell, B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Biochem. J. 1996, 313, 17-29
3. Akindele, A. J.; Ezenwanebe, K. O.; Anunobi, C. C.; Adeyemi, O. O. Hepatoprotective and in vivo antioxidant effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) J. Ethnopharmacol. 2010, 129, 46-52
4. Manibusan, M. K.; Odin, M.; Eastmond, D. A. Postulated carbon tetrachloride mode of action: a review J. Environ. Sci. Health C: Environ. Carcinog. Ecotoxicol. Rev. 2007, 25, 185-209
5. Ozturk, I. C.; Ozturk, F.; Gul, M.; Ates, B.; Cetin, A. Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats Cell Biochem. Funct. 2009, 27, 309-315
6. Issa, A. Y.; Volate, S. R.; Wargovich, M. J. The role of phytochemicals in inhibition of cancer and inflammation: new directions and perspectives J. Food Compos. Anal. 2006, 19, 405-419
7. 4-induced oxidative stress in rats Food Chem. Toxicol. 2009, 47, 716-721
8. Cuevas-Rodriguez, E. O.; Yousef, G. G.; Garcia-Saucedo, P. A.; Lopez-Medina, J.; Paredes-Lopez, O.; Lila, M. A. Characterization of anthocyanins and proanthocyanidins in wild and domesticated Mexican blackberries (Rubus spp.) J. Agric. Food Chem. 2010, 58, 7458-7464
9. Bowen-Forbes, C. S.; Zhang, Y.; Nair, M. G. Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits J. Food Compos. Anal. 2010, 23, 554-560
10. Cuevas-Rodriguez, E. O.; Dia, V. P.; Yousef, G. G.; Garcia-Saucedo, P. A.; Lopez-Medina, J.; Paredes-Lopez, O.; Gonzalez de Mejia, E.; Lila, M. A. Inhibition of pro-inflammatory responses and antioxidant capacity of Mexican blackberries (Rubus spp.) extracts J. Agric. Food Chem. 2010, 58, 9542-9548
11. Srivastava, A.; Greenspan, P.; Hartle, D. K.; Hargrove, J. L.; Amarowicz, R.; Pegg, R. B. Antioxidant and anti-inflammatory activities of polyphenolics from southeastern U.S. range blackberry cultivars J. Agric. Food Chem. 2010, 58, 6102-6109
12. Hassimotto, N. M. A.; Lajolo, F. M. Antioxidant status in rats after long-term intake of anthocyanins and ellagitannins from blackberries J. Sci. Food Agric. 2011, 91, 523-531
13. Pergola, C.; Rossi, A.; Dugo, P.; Cuzzocrea, S.; Sautebin, L. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract Nitric Oxide 2006, 15, 30-39
14. Ding, M.; Feng, R.; Wang, S. Y.; Bowman, L.; Lu, Y.; Qian, Y.; Castranova, V.; Jiang, B. H.; Shi, X. Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity J. Biol. Chem. 2006, 281, 17359-17368
15. Julkunen-Tiitto, R. Phenolics constituents in the leaves of northern willows: methods for the analysis of certain phenolics J. Agric. Food Chem. 1985, 33, 213-217
16. Giusti, M. M.; Wrolstad, R. E. Characterization and measurement of anthocyanins by UV-visible spectroscopy. In Current Protocols in Food Analytical Chemistry; Wrolstad, R. E., Ed.; Wiley: New York, 2001; units F1.2.1-F1.2.13.
17. Lee, B. W.; Lee, J. H.; Gal, S. W.; Moon, Y. H.; Park, K. H. Selective ABTS radical-scavenging activity of prenylated flavonoids from Cudrania tricuspidata Biosci., Biotechnol., Biochem. 2006, 70, 427-432
18. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying improved ABTS radical cation decolorization assay Free Radical Biol. Med. 1999, 26, 1231-1237
19. Stintzing, F. C.; Stintzing, A. S.; Carle, R.; Wrolstad, R. E. A novel zwitterionic anthocyanin from evergreen blackberry (Rubus laciniatus Willd.) J. Agric. Food Chem. 2002, 50, 396-399
20. Dai, J.; Gupte, A.; Gates, L.; Mumper, R. J. A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: extraction methods, stability, anticancer properties and mechanisms Food Chem. Toxicol. 2009, 47, 837-847
21. Dugo, P.; Mondello, L.; Errante, G.; Zappia, G.; Dugo, G. Identification of anthocyanins in berries by narrow-bore high performance liquid chromatography with electrospray ionization dectection J. Agric. Food Chem. 2001, 49, 3987-3992
22. Elisia, I.; Hu, C.; Popovich, D. G.; Kitts, D. D. Antioxidant assessment of an anthocyanin-enriched blackberry extract Food Chem. 2007, 101, 1052-1058
23. Patras, A.; Brunton, N. P.; O'Donnell, C.; Tiwari, B. K. Effect of thermal processing on anthocyanin stability in foods; mechanisms and kinetics of degradation Trends Food Sci. Technol. 2010, 21, 3-11
24. Sariburun, E.; Sahin, S.; Demir, C.; Turkben, C.; Uylaser, V. Phenolic content and antioxidant activity of raspberry and blackberry cultivars J. Food Sci. 2010, 75, C328-C335
25. Hsu, Y. W.; Tsai, C. F.; Chuang, W. C.; Chen, W. K.; Ho, Y. C.; Lu, F. J. Protective effects of silica hydride against carbon tetrachloride-induced hepatotoxicity in mice Food Chem. Toxicol. 2010, 48, 1644-1653
26. Ilavarasan, R.; Vasudevan, M.; Anbazhagan, S.; Venkataraman, S. Antioxidant activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver injury in rats J. Ethnopharmacol. 2003, 87, 227-230
27. Giudice, A.; Montella, M. Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention BioEssays 2006, 28, 169-181
28. Zhang, Q.; Pi, J.; Woods, C. G.; Andersen, M. E. A systems biology perspective on Nrf2-mediated antioxidant response Toxicol. Appl. Pharmacol. 2010, 244, 84-97
29. Wang, X.; Hai, C. X.; Liang, X.; Yu, S. X.; Zhang, W.; Li, Y. L. The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: role of Nrf2 and antioxidant enzymes J. Ethopharmacol. 2010, 127, 424-432
30. Sahin, K.; Tuzcu, M.; Gencoglu, H.; Dogukan, A.; Timurkan, M.; Sahin, N.; Aslan, A.; Kucuk, O. Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats Life Sci. 2010, 87, 240-245
31. Adesanoye, O. A.; Farombi, E. O. Hepatoprotective effects of Vernonia amygdalina (Astereaceae) in rats treated with carbon tetrachloride Exp. Toxicol. Pathol. 2010, 62, 197-206
32. 4 induced hepatic damage in rats J. Ethnopharmacol. 2010, 127, 777-780