Manganese-induced oxidative stress

Oxidative Stress and Neurodegenerative Disorders

Volumn , Issue , 2007, Pages 433-450

  Dobson, Allison W ^a   Aschner, Michael ^b  

^a WINSTON SALEM STATE UNIVERSITY   (United States)

^b Winston Salem   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84867311513     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-044452809-4/50160-5     Document Type: Chapter

References (163)

1. JW Finley and CD Davis (1999) Manganese deficiency and toxicity: are high or low dietary amounts of manganese cause for concern? Biofactors 10 15-24.
2. MA Verity (1999) Manganese neurotoxicity: a mechanistic hypothesis. Neurotoxicology 20 489-497.
3. A Takeda (2003) Manganese action in brain function. Brain Res Rev. 41 79-87.
4. D Hamai and SC Bondy (2004) Oxidative basis of manganese neurotoxicity. Ann NY Acad Sci. 1012 129-141.
5. AW Dobson, KM Erikson and M Aschner (2004) Manganese neurotoxicity. Ann NY Acad Sci. 1012 115-128.
6. CM Fored, JP Fryzek, L Brandt, G Nise, B Sjogren, JK McLaughlin, WJ Blot and A Ekbom (2006) Parkinson's disease and other basal ganglia or movement disorders in a large nationwide cohort of Swedish welders. Occup Environ Med. 63 135-140.
7. D Hamai, AL Rinderknecht, K Guo-Sharman, MT Kleinman and SC Bondy (2006) Decreased expression of inflammation-related genes following inhalation exposure to manganese. Neurotoxicology Epub Feb 27(3), 395-401.
8. CJ Chen, YC Ou, SY Lin, SL Liao, SY Chen and JH Chen (2006) Manganese modulates pro-inflammatory gene expression in activated glia. Neurochem Int. [Epub ahead print] July 49(1), 62-71.
9. AS Hazell, L Normandin, MD Norenberg, G Kennedy and JH Yi (2006) Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett. 396 167-171.
10. SG Han, Y Kim, ML Kashon, DL Pack, V Castranova and V Vallyathan (2005) Correlates of oxidative stress and free-radical activity in serum from asymptomatic shipyard welders. Am J Respir Crit Care Med. 172 1541-1548.
11. J Kaiser (2003) Manganese: a high-octane dispute. Science 300 926-928.
12. JA Pennington and SA Shoen (1996) Total Diet Study: estimated dietary intakes of nutritional elements. Int J Vitam Nutr Res. 66 350-362. 1982-1991
13. CE Casey, KM Hambidge and MC Neville (1985) Studies in human lactation: zinc, copper, manganese, and chromium in human milk in the first month of lactation. Am J Clin Nutr. 41 1193-1200.
14. D Stastey, RS Vogel and MF Picciano (1984) Manganese intake and serum manganese concentration of human milk-fed and formula-fed infants. Am J Clin Nutr. 39
15. LA Vaughan, CW Weber and SR Kemberling (1979) Longitudinal changes in the mineral content of human milk. Am J Clin Nutr. 32 2301-2306.
16. GA Wasserman, X Liu, F Parvez, H Ahsan, D Levy, P Factor-Litvak, J Kline, G.A. van Geen A, V Slavkovich, NJ LoIacono, Z Cheng, Y Zheng and JH Graziano (2006) Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 114(1), 124-129.
17. R Kawamura, et al. (1941) Intoxication by manganese in well water. Arch Exp Med. 18 145-169.
18. XG Kondakis, et al. (1989) Possible health effects of high manganese concentrations in drinking water. Arch Environ Health 44 175-178.
19. P Vieregge, B Heinzow, G Korf, HM Teichert, P Schleifenbaum and HU Mosinger (1995) Long term exposure to manganese in rural well water has no neurological effects. Can J Neurol Sci. 22 286-289.
20. JL Aschner and M Aschner (2005) Nutritional aspects of manganese homeostasis. Mol Aspects Med. Oct; 26 4-5 353-362.
21. Agency for toxic substances and disease registry. Toxicological profile for manganese. U.S. Department of Health and Human Services Public Health Service http://www.atsdr.cdc.gov/toxprofiles/tp151.html Available at
22. PJ Lioy (1983) Air pollution emission profiles of toxic and trace elements from energy related sources: status and needs. Neurotoxicology 4 103-112.
23. DR Lynam, JW Roos, GD Pfeifer, BF Fort and TG Pullin (1999) Environmental effects and exposures to manganese from use of methylcyclopenta-dienyl manganese tricarbonyl (MMT) in gasoline. Neurotoxicology 20 145-150.
24. J Zayed, C Thibault, L Gareau and G Kennedy (1999) Airborne manganese particulates and methylcyclopentadienyl manganese tricarbonyl (MMT) at selected outdoor sites in Montreal. Neurotoxicology 20 151-157.
25. CA Clayton, et al. (1999) Estimating distributions of long-term particulate matter and manganese exposures for residents of Toronto, Canada. Atmos Environ. 33 2515-2526.
26. S Loranger and J Zayed (1997) Environmental contamination and human exposure to airborne total and respirable manganese in Montreal. J Air Waste Manag Assoc. 47 983-989.
27. ED Pellizari, CA Clayton, CE Rodes, RE Mason, LL Piper, B Fort, G Pfeifer and D Lynam (1999) Particulate matter and manganese exposures in Toronto, Canada. Atmos Environ. 33 721-734.
28. GB Gerber, A Leonard and P Hantson (2002) Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. April 42(1), 25-34.
29. NAS (2002) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. http://www.nap.edu/books/0309072794/html Available at
30. JW Finley, PE Johnson and LK Johnson (1994) Sex affects manganese absorption and retention by humans from a diet adequate in manganese. Am J Clin Nutr. 60 949-955.
31. CD Davis, L Zech and JL Greger (1993) Manganese metabolism in rats: an improved methodology for assessing gut endogenous losses. Proc Soc Exp Biol Med. 202 103-108.
32. L Davidson, et al. (1988) Intrinsic and extrinsic labeling for studies of manganese absorption in humans. J Nutr. 118 1517-1521.
33. N Ballatori, E Miles and TW Clarkson (1987) Homeostatic control of manganese excretion in the neonatal rat. Am J Physiol. 252 R842-R847.
34. EA Malecki, GM Radzanowski, TJ Radzanowski, DD Gallaher and JL Greger (1996) Biliary manganese excretion in conscious rats is affected by acute and chronic manganese intake, but not by dietary fat. J Nutr. 126 489-498.
35. M Aschner, KM Erikson and DC Dorman (2005) Manganese dosimetry: species differences and implications for neurotoxicity. Crit Rev Toxicol. 35 1-32.
36. NAS (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. http://www.nap.edu/books/0309072794/html Available at
37. CL Keen, JG Bell and B Lonnerdal (1986) The effect of age on manganese uptake and retention from milk and infant formulas in rats. J Nutr. 116 395-402.
38. SH Zlotkin, S Atkinson and G Lockitch (1995) Trace elements in nutrition for premature infants. Clin Perinatol. 22 223-240.
39. K Dornar, S Dziadzka, A Hohn, E Sievers, HD Oldigs, G Schulz-Lell and J Schaub (1989) Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas. Br J Nutr. 61 559-572.
40. N Gruden (1977) Suppression of transduodenal manganese transport by milk diet supplemented with iron. Nutr Metab. 21 305-309.
41. M Krachler and E Rooipal (2000) Concentrations of trace elements in extensively hydrolysed infant formulae and their estimated daily intakes. Ann Nutr Metab. 44 68-74.
42. B Blonnerdal (1994) Nutritional aspects of soy formula. Acta Paediatr. Suppl. 402 105-108.
43. J Freeland-Grave and C Llanes (1998) Models to study manganese deficiency. Manganese in Health and Disease Boca Raton, FL: CRC Press 115-120.
44. CL Keen, JL Ensunsa, MH Watson, DL Baly, SM Donovan, MH Monaco and MS Clegg (1999) Nutritional aspects of manganese from experimental studies. Neurotoxicology 20 213-223.
45. JA Garcia-Aranda, RA Wapnir and F Lifshitz (1983) In vivo intestinal absorption of manganese in the rat. J Nutr. 113 2601-2607.
46. JG Bell, CL Keen and B Lonnerdal (1989) Higher retention of manganese in suckling than in adult rats is not due to maturational differences in manganese uptake by rat small intestine. J Toxicol Environ Health 26 387-398.
47. AA Britton and GC Cotzias (1966) Dependence of manganese turnover on intake. Am J Physiol. 211 203-206.
48. DC Dorman, MF Struve, RA James, BE McManus, MW Marshall and BA Wong (2001) Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats. Toxicol Sci. 60 242-251.
49. L Davidson, et al. (1991) The effect of individual dietary components on manganese absorption in humans. Am J Clin Nutr. 54 1065-1070.
50. JC Lai, MJ Minski, AW Chan, TK Leung and L Lim (1999) Manganese mineral interactions in brain. Neurotoxicology 20 433-444.
51. S.-M.N. Planells Sanchez-Morito N, MA Montellano, P Aranda and J Llopis (2000) Effect of magnesium deficiency on enterocyte Ca, Fe, Cu, Zn, Mn, and Se content. J Physiol Biochem. 56 217-222.
52. CD Davis, EA Malecki and JL Greger (1992) Interactions among dietary manganese, heme iron, and nonheme iron in women. Am J Clin Nutr. 56 926-932.
53. H Gunshin, B Mackenzie, UV Berger, Y Gunshin, MF Romero, WF Boron, S Nussberger, JL Gollan and MA Hediger (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 482-488.
54. VS Chandra and GS Shukla (1976) Role of iron deficiency in inducing susceptibility to manganese toxicity. Arch Toxicol. 35 319-323.
55. A Shukla, NS Agawal and GS Shukla (1989) Effect of latent iron deficiency on metal levels of rat brain regions. Biol Trace Elem Res. 22 141-152.
56. KM Erikson, ZK Shihabi, JL Aschner and M Aschner (2002) Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res. 87 143-156.
57. H Roels, G Meiers, M Delos, I Ortega, R Lauwerys, JP Buchet and D Lison (1997) Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats. Arch Toxicol. 71 223-230.
58. DC Dorman, MF Struve, RA James, MW Marshall, CU Parkinson and BA Wong (2001) Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following r. Toxicol Appl Pharmacol. 170 79-87.
59. P Aisen, R Aasa and AG Redfield (1969) The chromium, manganese, and cobalt complexes of transferrin. J Biol Chem. 244 4628-4633.
60. JW Critchfield and CL Keen (1992) 2 exhibits dynamic binding to multiple ligands in human plasma. Manganese Metab. 41 1087-1092.
61. F Ueda, KB Raja, RJ Simpson, IS Trowbridge and MW Bradbury (1993) Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor. J Neurochem. 60 106-113.
62. M Aschner and JL Aschner (1990) Manganese transport across the blood-brain barrier: relationship to iron homeostasis. Brain Res Bull. 24 857-860.
63. JS Crossgrove, DD Allen, BL Bukaveckas, SS Rhineheimer and RA Yokel (2003) Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transf. Neurotoxicology 24 3-13.
64. CL Keen and S Zidenberg-Cherr (1994) Manganese toxicity in humans and experimental animals. Manganese in Health and Disease Boca Raton, FL: CRC Press 193-205.
65. GL Rehnberg, JF Hein, SD Carter and JW Laskey (1980) Chronic manganese oxide administration to preweanling rats: manganese accumulation and distribution. J Toxicol Environ Health 6 217-226.
66. EA Malecki, AG Devenyi, TF Barron, TJ Mosher, P Eslinger, CV Flaherty-Craig and L Rossaro (1999) Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity. Neurotoxicology 20 647-652.
67. V Herynek, M Babis, P Trunecka, K Filip, J Vymazal, M Dezortova and M Hajek (2001) Chronic liver disease: relaxometry in the brain after liver transplantation. MAGMA 12 10-15.
68. S Montes, M Alcaraz-Zubeldia, P Muriel and C Rios (2001) Striatal manganese accumulation induces changes in dopamine metabolism in the cirrhotic rat. Brain Res. 891 123-129.
69. VA Murphy, KC Wadhwani, QR Smith and SI Rapoport (1991) Saturable transport of manganese(II) across the rat blood-brain barrier. J Neurochem. 57 948-954.
70. O Rabin, L Hegedus, JM Bourre and QR Smith (1993) Rapid brain uptake of manganese(II) across the blood-brain barrier. J Neurochem. 61 509-517.
71. KA Brennemann, BA Wong, MA Buccellato, ER Costa, EA Gross and DC Dorman (2000) Direct olfactory transport of inhaled manganese ((54)MnCl(2)) to the rat brain: toxicokinetic investigations in a unilateral nasal occlusion model. Toxicol Appl Pharmacol. 169 238-248.
72. S.U. AschnerMU Sonnewald U and KH Tan (2002) Astrocyte modulation of neurotoxic injury. Brain Pathol. 12 475-481.
73. AS Hazell (2002) Astrocytes and manganese neurotoxicity. Neurochem Int. 41 271-277.
74. E Tiffany-Castiglion and Y Qain (2001) Astroglia as metal depots: molecular mechanisms for metal accumulation, storage, and release. Neurotoxicology 22 577-592.
75. KC Wadwani, et al. (1992) Saturable transport of manganese(II) across blood-nerve barrier of rat peripheral nerve. Am J Physiol. 262 R284-R288.
76. A Takeda, J Sawashita and S Okada (1998) Manganese concentration in rat brain: manganese transport from the peripheral tissues. Neurosci Lett. 242 45-48.
77. EA Malecki, et al. (1999) Existing and emerging mechanisms for transport of iron and manganese to the brain. J Neurosci Res. 56 113-122.
78. N Suares and H Erikson (1993) Receptor-mediated endocytosis of a manganese complex of transferrin into neuroblastoma (SHSY5Y) cells in culture. J Neurochem. 61 127-131.
79. M Aschner and M Gannon (1994) Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain Res Bull. 33 345-349.
80. MC Newland, C Cox, R Hamada, G Oberdorster and B Weiss (1987) The clearance of manganese chloride in the primate. Fundam Appl Toxicol. 9 314-328.
81. GC Cotzias, K Horiuchi, S Fuenzalida and I Mena (1968) Chronic manganese poisoning. Clearance of tissue manganese concentrations with persistance of the neurological picture. Neurology 376-382 18
82. A Takeda, J Sawashita and S Okada (1995) Biological half-lives of zinc and manganese in rat brain. Brain Res. 695 53-58.
83. DC Dorman, MF Struve, D Vitarella, FL Byerly, J Goetz and R Miller (2000) Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. J Appl Toxicol. 20(3), 179-187.
84. TK Dickinson, AG Devenyi and JR Connor (1996) Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice. J Lab Clin Med. 128 270-278.
85. AC Chua and EH Morgan (1997) Manganese metabolism is impaired in the Belgrade laboratory rat. J Comp Physiol. B167 361-369.
86. RA Yokel and JS Crossgrove (2004) Manganese toxicokinetics at the blood-brain barrier. Res Rep Health Eff Inst. 119 7-58. discussion: 59-73
87. JA Roth and MD Garrick (2003) Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol. 66(1), 1-13.
88. MD Garrick and KG Dolan (2002) An expression system for a transporter of iron and other metals. Methods Mol Biol. 196 147-154.
89. RA Yokel, JS Crossgrove and BL Bukaveckas (2003) Manganese distribution across the blood-brain barrier. II. Manganese efflux from the brain does not appear to be carrier mediated. Neurotoxicology 24 15-22.
90. S Marthison, et al. (1998) Nasal route for direct delivery of solutes to the central nervous system: fact or fiction? J Drug Target 5 415-441.
91. G Gianutsos, GR Morrow and JB Morris (1997) Accumulation of manganese in rat brain following intranasal administration. Fundam Appl Toxicol. 37 102-105.
92. Transport of manganese via the olfactory pathway in rats: dosage dependency of the uptake and subcellular distribution of the metal in the olfactory epitheliu. Toxicol Appl Pharmacol. 156 119-128.
93. CP Lin, WY Tseng, HC Cheng and JH Chen (2001) Validation of diffusion tensor magnetic resonance axonal fiber imaging with registered manganese-enhanced optic tracts. Neuroimage 14 1035-1047.
94. KS Saleem, JM Pauls, M Augath, T Trinath, BA Prause, T Hashikawa and NK Logothetis (2002) Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron 34 685-700.
95. H Tjalve and J Henriksson (1999) Uptake of metals in the brain via olfactory pathways. Neurotoxicology 20 181-195.
96. H Tjalve, C Mejare and K Borg-Neczak (1995) Uptake and transport of manganese in primary and secondary olfactory neurones in pike. Pharmacol Toxicol. 77 23-31.
97. CD Dorman, KA Brenneman, AM McElveen, SE Lynch, KC Roberts and BA Wong (2002) Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain. J Toxicol Environ Health A65 1493-1511.
98. H Tjalve, et al. (1996) Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol Toxicol. 79 347-356.
99. DC Dorman, H Tjalve, et al. (1997) Olfactory neurotoxicology. Nervous System and Behavioral Toxicology Comprehensive Toxicology 11 Cambridge, UK: Elsevier 281-294.
100. Y Kafrista, J Fell, S Long, M Bynevelt, W Taylor and P Milla (1998) Long-term outcome of brain manganese deposition in patients on home parenteral nutrition. Arch Dis Child. 79 263-265.
101. DB Calne, NS Chu, CC Huang, CS Lu and W Olanow (1994) Manganism and idiopathic parkinsonism: similarities and differences. Neurology 44 1583-1586.
102. H Eriksson, J Tedroff, KA Thuomas, SM Aquilonius and P Hartvig (1992) Manganese induced brain lesions in Macaca fascicularis as revealed by positron emission tomography and magnetic resonance imaging. Arch Toxicol. 66 403-407.
103. S Nagatomo, F Umehara, K Hanada, Y Nobuhara, S Takenaga, K Arimura and M Osame (1999) Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature. J Neurol Sci. 162 102-105.
104. KA Brennehem, et al. (1999) Manganese-induced developmental neurotoxicity in the CD rat: is oxidative damage a mechanism of action? Neurotoxicology 20 477-487.
105. N Ballatori, E Miles and TW Clarkson (1987) Homeostatic control of manganese excretion in the neonatal rat. Am J Physiol. 252 R842-R847.
106. D Krieger, S Krieger, O Jansen, P Gass, L Theilmann and H Lichtnecker (1995) Manganese and chronic hepatic encephalopathy. Lancet 346(8970), 270-274.
107. S Montes, M Alcaraz-Zubeldia, P Muriel and C Rios (2001) Striatal manganese accumulation induces changes in dopamine metabolism in the cirrhotic rat. Brain Res. 891 123-129.
108. C Rose, RF Butterworth, J Zayed, L Normandin, K Todd, A Michalak, L Spahr, PM Huet and G Pomier-Layrargues (1999) Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology 117 640-644.
109. JM Reimund, JL Dietemann, JM Warter, R Baumann and B Duclos (2000) Factors associated to hypermanganesemia in patients receiving home parenteral nutrition. Clin Nutr. 19 343-348.
110. S Ikeda, Y Yamaguchi, Y Sera, H Ohshiro, S Uchino, Y Yamashita and M Ogawa (2000) Manganese deposition in the globus pallidus in patients with biliary atresia. Transplantation 69 2339-2343.
111. S Ikeda, Y Sera, M Yoshida, H Ohshiro, S Uchino, Y Oka, KJ Lee and A Kotera (2000) Manganese deposits in patients with biliary atresia after hepatic porto-enterostomy. J Pediatr Surg. 35 450-453.
112. D Mergler, G Huel, R Bowler, A Iregren, S Belanger, M Baldwin, R Tardif, A Smargiassi and L Martin (1994) Nervous system dysfunction among workers with long-term exposure to manganese. Environ Res. 64 151-180.
113. PK Pal, H Tjalve, A Samii and DB Calne (1999) Manganese neurotoxicity: a review of clinical features, imaging, and pathology. Neurotoxicology 20 227-238.
114. A Beuter, D Mergler, G.A. de Geoffroy A, L Carriere, S Belanger and L Varghese (1994) Diadochokinesimetry: a study of patients with Parkinson's disease and manganese exposed workers. Neurotoxicology 15 655-664.
115. H Roels, R Lauwerys, P Genet, MJ Sarhan, F.M. de Fays M, I Hanotiau and JP Buchet (1987) Relationship between external and internal parameters of exposure to manganese in workers from a manganese oxide and salt producing plant. Am J Ind Med. 11 297-305.
116. SA Gurgueira, J Lawrence, B Coull, GG Murthy and B Gonzalez-Flecha (2002) Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect 110 749-755.
117. Y Jiang and W Zheng (2005) Cardiovascular toxicities upon manganese exposure. Cardiovasc Toxicol. 5(4), 345-354.
118. KM Hambridge, et al. (1989) Plasma manganese concentrations in infants and children receiving parenteral nutrition. J Parenter Enteral Nutr. 13 168-171.
119. J Kurkus, et al. (1984) Manganese content of large-volume parenteral solutions and of nutrient additives. J Parenter Enteral Nutr. 8 254-257.
120. DB Bertinet, M Tinivella, FA Balzola, F.A. de Francesco A, O Davini, L Rizzo, P Massarenti, MA Leonardi and F Balzola (2000) Brain manganese deposition and blood levels in patients undergoing home parenteral nutrition. JPEN J Parenter Enteral Nutr. 24 223-227.
121. J Ono, K Harada, R Kodaka, K Sakurai, H Tajiri, Y Takagi, T Nagai, T Harada, A Nihei, A Okada, et al. (1995) Manganese deposition in the brain during long-term total parenteral nutrition. JPEN J Parenter Enteral Nutr. 19 310-312.
122. S Nagatomo, F Umehara, K Hanada, Y Nobuhara, S Takenaga, K Arimura and M Osame (1999) Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature. J Neurol Sci. 162 102-105.
123. Y Takagi, A Okada, K Sando, M Wasa, H Yoshida and N Hirabuki (2002) Evaluation of indexes of in vivo manganese status and the optimal intravenous dose for adult patients undergoing home parenteral nutrition. Am J Clin Nutr. 75 112-118.
124. A Carlsson and M Carlsson (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia implications for schizophrenia and Parkinson's disease. Trends Neurosci. 13 272-276.
125. VA Fitsanakis and M Aschner (2005) The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity. Toxicol Appl Pharmacol. 204 343-354.
126. JP Blass (2001) Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? J Neurosci Res. 66 851-856.
127. RH Gwiazda, D Lee, J Sheridan and DR Smith (2002) Low cumulative manganese exposure affects striatal GABA, but not dopamine. Neurotoxicology 23 69-76.
128. KM Erikson and M Aschner (2003) Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int. 43 475-480.
129. GW Lipe, H Duhart, GD Newport, J.W. Slikker Jr.W and SF Ali (1999) Effect of manganese on the concentration of amino acids in different regions of the rat brain. J Environ Sci Health B34 119-132.
130. RL Albin (2000) Basal ganglia neurotoxins. Neurol Clin. 18 665-680.
131. DC Dorman, MF Struve, D Vitarella, FL Byerly, J Goetz and R Miller (2000) Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. J Appl Toxicol. 20 179-187.
132. MC Newland (1999) Animal models of manganese's neurotoxicity. Neurotoxicology 20 415-432.
133. BA Pappas, D Zhang, CM Davidson, T Crowder, GA Park and T Fortin (1997) Perinatal manganese exposure: behavioral, neurochemical, and histopathological effects in the rat. Neurotoxicol Teratol. 19 17-25.
134. DS Alber and MF Beal (2000) Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neura Transm. Suppl. 59 133-154.
135. CEH Given, et al. (1999) Manganese and calcium transport in mitochondria: implications for manganese toxicity. Neurotoxicology 20 445-453.
136. V Calabrese, G Scapagnini, S.A.M. Giuffrida Stella AM, TE Bates and JB Clark (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochem Res. 26 739-764.
137. KB Beckman and BN Ames (1998) Mitochondrial aging: open questions. Ann NY Acad Sci. 854 118-127.
138. S Melove (2000) Mitochondrial oxidative stress: physiologic consequences and potential for a role in aging. Ann NY Acad Sci. 908 219-225.
139. A Roth, et al. (2000) Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation. J Neurosci Res. 61 162-171.
140. LS Maynard and GC Cotzias (1954) The partition of manganese among organs and intracellular organelles of the rat. J Biol Chem. 214 489-495.
141. EA Malecki (2001) Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons. Brain Res Bull. 55 225-228.
142. M Basso, S Giraudo, D Corpillo, B Bergamasco, L Lopiano and M Fasano (2004) Proteome analysis of human substantia nigra in Parkinson's disease. Proteomics 4 3943-3952.
143. R Witholt, RH Gwiazda and DR Smith (2000) The neurobehavioral effects of subchronic manganese exposure in the presence and absence of pre-parkinsonism. Neurotoxicol Teratol. 22 851-861.
144. V Anantharam, et al. (2002) Is essential Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta for oxidative stress-mediated dopaminergic cell death after exposure to methylc. J Neurosci. 22 1738-1751.
145. M Kitazawa, JR Wagner, ML Kirby, V Anantharam and AG Kanthasamy (2002) Oxidative stress and mitochondrialmediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. J Pharmacol Exp Ther. 302 26-35.
146. F Cardozo-Pelaez, DP Cox and C Bolin (2005) Lack of the DNA repair enzyme OGG1 sensitizes dopamine neurons to manganese toxicity during development. Gene Expr. 12(4-6), 315-323.
147. C Zwingmann, D Leibfritz and AS Hazell (2003) Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular traffic. J Cereb Blood Flow Metab. 23 756-771.
148. ME Gegg, JB Clark and SJ Heales (2005) Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligas. Brain Res. 1036(1-6)
149. L Bambrick, T Kristian and G Fiskum (2004) Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochem Res. 29(3), 601-608.
150. FS Archibald and C Tyree (1987) Manganese poisoning and the attack of trivalent manganese upon catecholamines. Arch Biochem Biophys. 256 638-650.
151. SF Ali, HM Duhart, GD Newport, GW Lipe and J.W. Slikker Jr.W (1995) Manganese-induced reactive oxygen species: comparison 3+2 and Mn+ between Mn. Neurodegeneration 4 329-334.
152. JY Chen, GC Tsao, Q Zhao and W Zheng (2001) Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes. Toxicol Appl Pharmacol. 175 160-168.
153. P Aisen, R Aasa and AG Redfield (1969) The chromium, manganese, and cobalt complexes of transferrin. J Biol Chem. 244 4628-4633.
154. KK Gunter, LM Miller, M Aschner, R Eliseev, D Depuis, CE Gavin and TE Gunter (2002) XANES spectroscopy: a promising tool for toxicology: a tutorial. Neurotoxicology 23 127-146.
155. KK Gunter, LM Miller, M Aschner, R Eliseev, D Depuis, CE Gavin and TE Gunte (2002) XANES spectroscopy: a promising tool for toxicology: a tutorial. Neurotoxicology 23(2), 127-146.
156. TE Gunter, LM Miller, CE Gavin, R Eliseev, J Salter, L Buntinas, A Alexandrov, S Hammond and KK Gunter (2004) Determination of the oxidation states of manganese in brain, liver, and heart mitochondria. J Neurochem. 88 266-280.
157. D Hamai, A Campbell and SC Bondy (2001) Modulation of oxidative events by multivalent manganese complexes in brain tissue. Free Radical Biol Med. 31 763-768.
158. S Melov (2002) Therapeutics against mitochondrial oxidative stress in animal models of aging. Ann NY Acad Sci. 959 330-340.
159. J Peng, FF Stevenson, SR Doctrow and JK Andersen (2005) Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implication. J Biol Chem. 280 29194-29198.
160. BI Lee, PH Chan and GW Kim (2005) Metalloporphyrin-based superoxide dismutase mimic attenuates the nuclear translocation of apoptosis-inducing factor and the subsequent DNA fragmentation after. Stroke 36 2712-2717.
161. SB Leinenweber, H Sheng, JR Lynch, H Wang, I Batinic-Haberle, DT Laskowitz, JD Crapo, RD Pearlstein and DS Warner (2006) Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. Eur J Pharmacol. 531 126-132.
162. S Melov, SR Doctrow, JA Schneider, J Haberson, M Patel, PE Coskun, K Huffman, DC Wallace and B Malfroy (2001) Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci. 21 8348-8353.
163. YG Abashkin and SK Burt (2005) (salen)MnIII compounds as nonpeptidyl mimics of catalase. Mechanism-based tuning of catalase activity: a theoretical study. Inorg Chem. 44 1425-1432.