Accumulation of manganese in rat brain following intranasal administration

Fundamental and Applied Toxicology

Volumn 37, Issue 2, 1997, Pages 102-105

  Gianutsos, Gerald ^a   Morrow, Gale R ^a   Morris, John B ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANGANESE CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN LEVEL; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DOSE TIME EFFECT RELATION; INTRANASAL DRUG ADMINISTRATION; MALE; NEUROTOXICITY; NONHUMAN; OLFACTORY BULB; OLFACTORY NUCLEUS; RAT;

ANIMALIA;

EID: 85033530949     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1997.2306     Document Type: Article

References (16)

1. Bird E. D., Anton A. H., Bullock B. The effect of manganese inhalation on basal ganglia dopamine concentrations in rhesus monkey. Neurotoxicology. 5:1984;59-65.
2. Clay R. J., Morris J. B. Comparative pneumotoxicity of cyclopentadienyl manganese tricarbonyl and methylcyclopentadienyl manganese tricarbonyl. Toxicol. Appl. Pharmacol. 98:1989;434-443.
3. Cotzias G. C., Papavasiliou P. S., Mena I., Tang L. C., Miller S. T. Manganese and catecholamines. Adv. Neurol. 5:1974;235-243.
4. Evans J., Hastings L. Accumulation of Cd(II) in the CNS depending on the route of administration: Intraperitoneal, intratracheal, or intranasal. Fundam. Appl. Toxicol. 19:1992;275-278.
5. Gianutsos G., Seltzer M. D., Saymeh R., Wang-Wu M. L., Michel R. G. Brain manganese accumulation following systemic administration of different forms. Arch. Toxicol. 57:1985;272-275.
6. Graham D. G. Catecholamine toxicity: A proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease. Neurotoxicology. 5:1984;83-95.
7. Hastings L., Evans J. E. Olfactory primary neurons as a route of entry for toxic agents into the CNS. Neurotoxicology. 12:1991;707-714.
8. Ingersoll R. T., Montgomery E. B. Jr., Aposhian H. V. Central nervous system toxicity of manganese. I. Inhibition of spontaneous motor activity in rats after intrathecal administration of manganese chloride. Fundam. Appl. Toxicol. 27:1995;106-113.
9. P. M. LeQuesne, 1992, Metal neurotoxicity, Diseases of the Nervous System, Clinical Neurobiology, 1250, 1258, Saunders, Philadelphia.
10. Mena I., Marin O., Fuenzalida S., Cotzias G. C. Chronic manganese poisoning. Clinical picture and manganese turnover. Neurology. 17:1967;128-136.
11. 2. Neurotoxicology. 6:1985;1-15.
12. Paynter D. I. Microdetermination of manganese in animal tissue by flameless atomic absorption spectrometry. Anal. Chem. 51:1979;2986-2989.
13. Perl D. P., Good D. F. Uptake of aluminum into central nervous system along nasal-olfactory pathways. Lancet. 1:1987;1028.
14. Rodier J. Manganese poisoning in Moroccan miners. Br. J. Ind. Med. 12:1955;21-35.
15. St. Clair M. B. G., Gross E. A., Morgan K. T. Pathology and cell proliferation induced by intra-nasal instillation of aldehydes in the rat: Comparison of glutaraldehyde and formaldehyde. Toxicol. Pathol. 18:1990;353-361.
16. Zheng W., Perry D. F., Nelson D. L., Aposhian H. V. Choroid plexus protects cerebrospinal fluid against toxic metals. FASEB J. 5:1991;2188-2193.