Anti-cancer gallotannin penta-O-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases

Biochemical Pharmacology

Volumn 80, Issue 8, 2010, Pages 1125-1132

  Mizushina, Yoshiyuki ^a   Zhang, Jinhui ^b   Pugliese, Angelo ^b   Kim, Sung Hoon ^b,c   Lü, Junxuan ^b  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Kyung Hee University   (South Korea)

Author keywords

Anticancer effect; DNA polymerase (pol); DNA replication; Enzyme inhibitor; Penta 1,2,3,4,6 O galloyl beta d glucose (PGG)

Indexed keywords

ANTINEOPLASTIC AGENT; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; DNA DIRECTED DNA POLYMERASE ETA; DNA DIRECTED DNA POLYMERASE IOTA; DNA DIRECTED DNA POLYMERASE KAPPA; NUCLEOTIDYLTRANSFERASE INHIBITOR; PENTA O GALLOYL BETA DEXTRO GLUCOSE; TANNIN; UNCLASSIFIED DRUG; BETA-PENTA-O-GALLOYL-GLUCOSE; DNA; NUCLEIC ACID SYNTHESIS INHIBITOR; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SYNTHESIS INHIBITION; DNA TEMPLATE; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; ENZYME STRUCTURE; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; SIMULATION; ANIMAL; BOVINAE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DNA DAMAGE; ENZYMOLOGY; HUMAN; METABOLISM; MOUSE; PLANT; PROTEIN CONFORMATION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; COMPUTER SIMULATION; DNA; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; HUMANS; HYDROLYZABLE TANNINS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLANTS; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; NUCLEIC ACID SYNTHESIS INHIBITORS;

EID: 77956224958     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.06.031     Document Type: Article

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