Immunology of tuberculosis

Indian Journal of Medical Research

Volumn 120, Issue 4, 2004, Pages 213-232

  Raja, Alamelu ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN TUBERCULOSIS   (India)

Author keywords

Immunology; Mycobacterium tuberculosis; Tuberculosis

Indexed keywords

BCG VACCINE; CD1 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CYTOKINE; FREE RADICAL; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; HLA ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; NITROGEN; RANTES; REACTIVE OXYGEN METABOLITE;

ANTIGEN PRESENTATION; APOPTOSIS; BACTERIAL GROWTH; BACTERIAL IMMUNITY; BACTERIAL TRANSMISSION; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; CELL MEDIATED CYTOTOXICITY; CELLULAR IMMUNITY; CONTROL STRATEGY; CORRELATION COEFFICIENT; CYTOKINE PRODUCTION; DISEASE MARKER; DISEASE PREDISPOSITION; DRUG DESIGN; GROWTH INHIBITION; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOGENETICS; IMMUNOPATHOGENESIS; IN VITRO STUDY; INFECTION CONTROL; INFECTION RISK; INTERFERON PRODUCTION; LEUKOCYTE ACTIVATION; LUNG ALVEOLUS MACROPHAGE; LUNG TUBERCULOSIS; LYSOSOME; MACROPHAGE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER CELL; NONHUMAN; PHAGOSOME; REVIEW; SUPERINFECTION; TH1 CELL; VIRUS PATHOGENESIS;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIGEN-PRESENTING CELLS; APOPTOSIS; CYTOKINES; DISEASE SUSCEPTIBILITY; HIV; HUMANS; IMMUNITY, CELLULAR; MACROPHAGES, ALVEOLAR; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES; TUBERCULOSIS;

EID: 8644263959     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (176)

1. World Health Organization. The World Health Report: Making a difference; 1999 p. 110.
2. Revised National Tuberculosis Control Programme: Key facts and concepts. New Delhi: Central TB Division, Directorate General of Health Services, Ministry of Health and Family Welfare; 1999.
3. Jayasankar K, Ramanathan VD. Biochemical and histochemical changes relating to fibrosis following infection with Mycobacterium tuberculosis in the guineapig. Indian J Med Res 1999; 110 : 91-7.
4. Schlesinger LS. Role of mononuclear phagocytes in M. tuberculosis pathogenesis. J Invest Med 1996; 44 : 312-23.
5. Schlesinger LS, Hull SR, Kaufman TM. Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. J Immunol 1994; 152: 4070-9.
6. Barnes PF, Modlin RL, Ellner JJ. T-cell responses and cytokines. In: Bloom BR, editor. Tuberculosis: Pathogenesis, protection and control. Washington, DC: ASM Press; 1994 p. 417-35.
7. Hoheisel G, Zheng L, Teschler H, Striz I, Costabel U. Increased soluble CD14 levels in BAL fluid in pulmonary tuberculosis. Chest 1995; 108 : 1614-6.
8. Gaynor C, McCormack FX, Voelker DR, McGowan SE, Schlesinger LS. Pulmonary surfactant protein A mediates enhanced phagotosis of Mycobacterium tuberculosis by a direct interaction with human macrophages. J Immunol 1995; 155 : 5343-51.
9. Cohn ZA. The fate of bacteria within phagocytic cells. I. The degradation of isotopically labeled bacteria by polymorphonuclear leucocytes and macrophages. J Exp Med 1963; 117 : 27-42.
10. Desjardins M, Huber LA, Parton RG, Griffiths G. Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus. J Cell Biol 1994; 124 : 677-88.
11. Hart PD, Armstrong JA, Brown CA, Draper P. Ultrastructural study of the behaviour of macrophages toward parasitic mycobacteria. Infect Immun 1972; 5 : 803-7.
12. Goren MB, Hart PD, Young MR, Armstrong JA. Prevention of phagosome lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1976; 73 : 2510-4.
13. Goren MB, Brokl O, Das BC. Sulfatides of Mycobacterium tuberculosis: the structure of the principal sulfatide (SL-I). Biochemistry 1976; 15 : 2728-35.
14. Gordon AH, Hart PD, Young MR. Ammonia inhibits phagosome-lysosome fusion in macrophages. Nature 1980; 286 : 79-81.
15. Walker L, Lowrie DB. Killing of Mycobacterium microti by immunologically activated macrophages. Nature 1981; 293 : 69-70.
16. Flesch I, Kaufmann SH. Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J Immunol 1987; 138 : 4408-13.
17. Selvaraj P, Venkataprasad N, Vijayan VK, Prabhakar R, Narayanan PR. Alveolar macrophages in patients with pulmonary tuberculosis. Lung India 1988; 6 : 71-4.
18. Swamy R, Acharyalu GS, Balasubramaniam R, Narayanan PR, Prabhakar R. Immunological investigations in tuberculous ascites. Indian J Tuberc 1988; 35 : 3-7.
19. Selvaraj P, Swamy R, Vijayan VK, Prabhakar R, Narayanan PR. Hydrogen peroxide producing potential of alveolar macrophages and blood monocytes in pulmonary tuberculosis. Indian J Med Res 1988; 88 : 124-9.
20. Chan J, Flynn JL. Nitric oxide in Mycobacterium tuberculosis infection. In: Fang, FC, editor. Nitric oxide and infection. New York: Kluwer Academic Plenum; 1999 p. 281-310.
21. MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acd Sci USA 1997; 94 : 5243-8.
22. Vishwanath V, Meera R, Puvanakrishnan R, Narayanan PR. Fate of Mycobacterium tuberculosis inside rat peritoneal macrophages in vitro. Mol Cell Biochem 1997; 175 : 169-75.
23. Rockett KA, Brookes R, Udalova I, Vidal V, Hill AV, Kwiatkowski D. 1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line. Infect Immun 1998; 66 : 5314-21.
24. Bonecini-Almeida MG, Chitale S, Boutsikakis I, Geng J, Doo H, He S, et al. Induction of in vitro human macrophage anti- Mycobacterium tuberculosis activity: requirement for IFN-gamma and primed lymphocytes. J Immunol 1998; 160 : 4490-9.
25. Nicholson S, Bonecini-Almeida HG, Lapae Silva JRL, Nathan C, Xie QW, Mumford R, et al. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med 1996; 183 : 2293-302.
26. Vishwanath V, Narayanan S, Narayanan PR. The fate of Mycobacterium tuberculosis in activated human macrophages. Curr Sci 1998; 75 : 942-6.
27. Rook GA, Steele J, Ainsworth M, Champion BR. Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages. Immunology 1986; 59 : 333-8.
28. Douvas GS, Looker DL, Vatter AE, Crowle AJ. Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun 1985; 50 : 1-8.
29. Denis M. Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol. Clin Exp Immunol 1991; 84: 200-6.
30. Placido R, Mancino G, Amendola A, Mariani F, Vendetti S, Piacentini M, et al. Apoptosis of human monocytes/macrophages in Mycobacterium tuberculosis infection. J Pathol 1997; 181 : 31-8.
31. Klingler K, Tchou-Wong KM, Brandli O, Aston C, Kim R, Chi C, et al. Effects of mycobacteria on regulation of apoptosis in mononuclear phagocytes. Infect Immun 1997; 65 : 5272-8.
32. Keane J, Balcewicz-Sablinska MK, Remold HG, Chupp GL, Meek BB, Fenton MJ, et al. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun 1997; 65 : 298-304.
33. Molloy A, Laochumroonvorapong P, Kaplan G. Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guerin. J Exp Med 1994; 180 : 1499-509.
34. Condos R, Rom WN, Liu Y, Schluger NW. Local immune responses correlate with presentation and outcome in tuberculosis. Am J Respir Crit Care Med 1997; 157 : 729-35.
35. Tan JS, Canaday DH, Boom WH, Balaji KN, Schwander SK, Rich EA. Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4 and CD8 cytotoxic T cells and relative resistance of alveolar macrophages to lysis. J Immunol 1997; 159 : 290-7.
36. Andersen P, Askgaard D, Ljungqvist L, Bennedsen J, Heron I. Proteins released from Mycobacterium tuberculosis during growth. Infect Immun 1991; 59 : 1905-10.
37. Chan J, Fujiwara T, Brennan P, McNeil M, Turco SJ, Sibille JC, et al. Microbial glycolipids: possible virulence factors that scavenge oxygen radicals. Proc Natl Acad Sci USA 1989; 86 : 2453-7.
38. Chan J, Fan XD, Hunter SW, Brennan PJ, Bloom BR. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun 1991; 59 : 1755-61.
39. Hmama Z, Gabathuler R, Jefferies WA, deJong G, Reiner NE. Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers. J Immunol 1998; 161: 4882-93.
40. Rojas RE, Balaji KN, Subramanian A, Boom WH. Regulation of human CD4+ αβ T cell receptor positive (TCR+) and γ δ (TCR +T-cell responses to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor β. Infect Immun 1999; 67 : 6461-72.
41. vanHeyningen TK, Collins HL, Russell DG. IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses. J Immunol 1997; 158 : 303-7.
42. Moreira AL, Wang J, Tsenova-Berkova L, Hellmann W, Freedman VH, Kaplan G. Sequestration of Mycobacterium tuberculosis in tight vacuoles in vivo in lung macrophages of mice infected by the respiratory route. Infect Immun 1997; 65 : 305-8.
43. Selvaraj P, Kannapiran M, Kurian SM, Narayanan, PR. Effect of plasma lysozyme on live Mycobacterium tuberculosis. Curr Sci 2001; 81 : 201-3.
44. Newport M, Levin M, Blackwell J, Shaw MA, Williamson R, Huxley C. Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred. J Med Genet 1995; 32 : 904-6.
45. Selvaraj P, Chandra, G, Kurian SM, Reetha AM, Charles N, Narayanan PR. NRAMP1 gene polymorphism in pulmonary and spinal tuberculosis. Curr Sci 2002; 82 : 451-4.
46. Edwards D, Kirkpatrick CH. The immunology of mycobacterial diseases. Am Rev Respir Dis 1986; 134 : 1062-71.
47. Fleischmann J, Golde DW, Weisbart RH, Gasson JC. Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils. Blood 1986; 68 : 708-11.
48. Ogata K, Linzer BA, Zuberi RI, Ganz T, Lehrer RI, Catanzaro A. Activity of Defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infect Immun 1992; 60 : 4720-5.
49. Majeed M, Perskvist N, Ernst JD, Orselius K, Stendahl O. Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. Microb Pathog 1998; 24 : 309-20.
50. Esin S, Batoni G, Kallenius G, Gaines H. Campa M. Svenson SB, et al. Proliferation of distinct human T cell subsets in response to live, killed or soluble extracts of Mycobacterium tuberculosis and Mycobacterium avium. Clin Exp Immunol 1996; 104 : 419-25.
51. Ratcliffe LT, Lukey PT, Mackenzie CR, Ress SR. Reduced NK activity correlates with active disease in HIV patients with multidrug-resistant pulmonary tuberculosis. Clin Exp Immunol 1994; 97 : 373-9.
52. Bermudez LE, Young LS. Natural killer cell-dependent mycobacteriostatic and mycobactericidal activity in human macrophages. J Immunol 1991; 146 : 265-70.
53. Molloy A, Meyn PA, Smith KD, Kaplan G. Recognition and destruction of bacillus Calmette-Guerin-infected human monocytes. J Exp Med 1993; 177 : 1691-8.
54. Nirmala R, Narayanan PR, Mathew R, Maran M, Deivanayagam CN. Reduced NK activity in pulmonary tuberculosis patients with/without HIV infection: Identifying the defective stage and studying the effect of interleukins on NK activity. Tuberculosis 2001; 81 : 343-52.
55. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388 : 394-7.
56. Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, Fenton MJ. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 1999; 163 : 3920-7.
57. Johnson CM, Cooper AM, Frank AA, Bonorino CBC, Wysoki LJ, Orme IM. Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. Tuber Lung Dis 1997; 78 : 257-61.
58. Bosio CM, Gardner D, Elkins KL. Infection of B cell-deficient mice with CDC1551, a clinical isolate of Mycobacterium tuberculosis delay in dissemination and development of lung pathology. J Immunol 2000; 164 : 6417-25.
59. Engers HD, Houba V, Bennedsen J, Buchanan TM, Chaparas SD, Kadival G, et al. Results of a World Health Organization sponsored Workshop to characterize antigens recognized by mycobacterium specific monoclonal antibodies. Infect Immun 1986; 51 : 718-20.
60. Uma Devi KR, Ramalingam B, Brennan PJ., Narayanan PR, Raja A. Specific and early detection of IgG, IgA and IgM antibodies to Mycobacterium tuberculosis 38kDa antigen in pulmonary tuberculosis. Tuberculosis 2001; 81 : 249-53.
61. Raja A, Uma Devi KR, Ramalingam B, Brennan PJ. Immunoglobulin G, A and M responses in serum and circulating immune complexes elicited by the 16kDa antigen of Mycobacterium tuberculosis. Clin Diagn Lab Immunol 2002; 9 : 308-12.
62. Uma Devi KR, Senthil Kumar KS, Ramalingam B, Raja A. Purification and characterization of three immunodominant proteins (38, 30, and 16 kDa) of Mycobacterium tuberculosis. Protein Expr Purif 2002; 24 : 188-95.
63. Raja A, Ranganathan UD, Bethunaickan R, Dharmalingam, V. Serologic response to a secreted and a cytosolic antigen of Mycobacterium tuberculosis in childhood tuberculosis. Pediatr Infect Dis J 2001; 20: 1161-4.
64. Ramalingam B, Uma Devi KR, Swaminathan S, Raja A. Isotype specific antibody response in Childhood tuberculosis against purified 38kDa antigen of Mycobacterium tuberculosis. J Trop Pediatr 2002; 48 : 188-9.
65. Uma Devi KR, Ramalingam B, Raja A. Qualitative and quantitative analysis of antibody response in childhood tuberculosis against antigens of Mycobacterium tuberculosis. Indian J Med Microbiol 2002; 20 : 145-9.
66. Senthil Kumar KS, Uma Devi KR, Raja A. Isolation and evaluation of diagnostic value of two major secreted proteins of Mycobacterium tuberculosis. Indian J Chest Dis Allied Sci 2002; 44 : 225-32.
67. Ramalingam B, Uma Devi KR, Raja A. Isotype specific anti-38 and 27kDa (mpt 51) response in pulmonary tuberculosis with human immunodeficiency virus coinfection. Scand J Infect Dis 2003; 35 : 234-9.
68. Uma Devi KR, Ramalingam B, Raja A. Antibody response to Mycobacterium tuberculosis 30 and 16kDa antigens in pulmonary tuberculosis with human immunodeficiency virus coinfection. Diagn Microbiol Infect Dis 2003; 46 : 205-9.
69. Raja A, Acharyulu GS, Selvaraj R, Khudoos A. Evaluation of antibody level to purified mycobacterial antigens for identification of tuberculous infection. Biomedicine 2001; 21: 63-9.
70. Senthil Kumar KS, Raja A, Uma Devi KR, Paranjape RS. Production and characterization of monoclonal antibodies to Mycobacterium tuberculosis. Indian J Med Res 2000; 112 : 37-46.
71. Feng CG, Bean AGD, Hooi H, Briscoe H, Britton WJ. Increase in gamma interferon- secreting CD8+, as well as CD4 + T cells in lungs following aerosol infection with Mycobacterium tuberculosis. Infect Immun 1999; 67 : 3242-7.
72. Randhawa PS. Lymphocyte subsets in granulomas of human tuberculosis: an in situ immunofluorescence study using monoclonal antibodies. Pathology 1990; 22 : 153-5.
73. Muller I, Cobbold SP, Waldmann H, Kaufmann SH. Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2 + T cells. Infect Immun 1987; 55 : 2037-41.
74. Orme IM, Collins FM. Adoptive protection of the Mycobacterium tuberculosis-infected lung. Cell Immunol 1984; 84 : 113-20.
75. Caruso AM, Serbina N, Klein E, Triebold K, Bloom BR, Flynn JL. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis. J Immunol 1999; 162 : 5407-16.
76. Selwyn PA, Hartel D, Lewis VA, Schoenbaum EE, Vermund SH, Klein RS, et al. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N Engl J Med 1989; 320 : 545-50.
77. Scanga CA, Mohan VP, Yu K, Joseph H, Tanaka K, Chan J, et al. Depletion of CD4+ T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon-γ and nitric oxide synthase. J Exp Med 2000; 192 : 347-58.
78. McDonough KA, Kress Y, Bloom BR. Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect Immun 1993; 61: 2763-73.
79. Teitelbaum R, Cammer M, Maitland ML, Freitag NE, Condeelis J, Bloom BR. Mycobacterial infection of macrophages results in membrane permeable phagosomes. Proc Natl Acad Sci USA 1999; 96 : 15190-5.
80. Yu CT, Wang CH, Huang TJ, Lin HC, Kuo HP. Relation of bronchoalveolar lavage T lymphocyte subpopulations to rate of regression of active pulmonary tuberculosis. Thorax 1995; 50 : 869-74.
81. Taha RA, Kotsimbos TC, Song YL, Menzies D, Hamid Q. IFN-gamma and IL-12 are increased in active compared with inactive tuberculosis. Am J Respir Crit Care Med 1997; 155 : 1135-9.
82. Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat JP, et al. Differential effects of cytolytic T cell subsets on intracellular infection. Science 1997; 276 : 1684-7.
83. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazik R, Froelich CS, et al. An antimicrobial activity of cytolytic T cells mediate by granulysin. Science 1998; 282 : 121-5.
84. Silva CL, Lowrie DB. Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis. Infect Immun 2000; 68 : 3269-74.
85. Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, et al. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol 1999; 73 : 2527-36.
86. Kremer L, Estaquier J, Wolowczuk I, Biet F, Ameisen JC, Locht C. Ineffective cellular immune response associated with T-cell apoptosis in susceptible Mycobacterium bovis BCG-infected mice. Infect Immun 2000; 68 : 4264-73.
87. Hirsch CS, Toossi Z, Johnson JL, Luzze H, Ntambi L, Peters P, et al. Augmentation of apoptosis and interferon-g production at sites of active Mycobacterium tuberculosis infection in human tuberculosis. J Infect Dis 2001; 183 : 779-88.
88. Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Okwera A, et al. Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis. J Infect Dis 1999; 179 : 945-53.
89. Varadhachary AS, Perdow SN, Hu C, Ramanarayanan M, Salgame P. Differential ability of T cell subsets to undergo activation-induced cell death. Proc Natl Acad Sci USA 1997; 94 : 5778-83.
90. Fayyazi A, Eichmeyer B, Sorui A, Schewyer S, Herms J, Schwarz P, et al. Apoptosis of macrophages and T cells in tuberculosis associated caseous necrosis. J Pathol 2000; 191 : 417-25.
91. Aravindhan V, Das S. In vivo study on dual-signal hypothesis and its correlation to immune response using mycobacterial antigen. Curr Sci 2001; 81 : 301-4.
92. Sulochana D., Deepa S., Prabha C. Cell proliferation and apoptosis: dual-signal hypothesis tested in tuberculous pleuritis using mycobacterial antigens. FEMS Immunol Med Microbiol 2004; 41: 85-92.
93. Moody DB, Ulrichs T, Muhlecker W, Young DC, Gurcha SS, Grant E, et al. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 2000; 404 : 884-8.
94. Sieling PA, Jullien D, Dahlem M, Tedder TF, Rea TH, Modlin RL, et al. CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J Immunol 1999; 162 : 1851-8.
95. Izzo AA, North RJ. Evidence for an α/β T cell-independent mechanism of resistance to mycobacteria. Bacillus-Calmette-Guerin causes progressive infection in severe combined immunodeficient mice, but not in nude mice or in mice depleted of CD4+ and CD8+ T cells. J Exp Med 1992; 176 : 581-6.
96. Munk ME, Gatrill AJ, Kaufmann SH. Target cell lysis and IL-2 secretion by gamma/delta T lymphocytes after activation with bacteria. J Immunol 1990; 145 : 2434-9.
97. Ueta C, Tsuyuguchi I, Kawasumi H, Takashima T, Toba H, Kishimoto S. Increase of gamma/delta T cells in hospital workers who are in close contact with tuberculosis patients. Infect Immun 1994; 62 : 5434-41.
98. Tazi A, Bouchonnet F, Valeyre D, Cadranel J, Battesti JP, Hance AJ. Characterization of gamma/delta T-lymphocytes in the peripheral blood of patients with active tuberculosis. A comparison with normal subjects and patients with sarcoidosis. Am Rev Respir Dis 1992; 146 : 1216-21.
99. Swaminathan S, Nandini KS, Hanna LE, Somu N, Narayanan PR, Barnes PF. T - lymphocyte subpopulations in tuberculosis. Indian Pediatr 2000; 37: 489-95.
100. Ladel CH, Hess J, Daugelat S, Mombaerts P, Tonegawa S, Kaufmann SH. Contribution of alpha/beta and gamma/delta T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guerin : studies with T cell receptor-deficient mutant mice. Eur J Immunol 1995; 25 : 838-46.
101. Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol 1993; 151 : 518-25.
102. Huygen K, Van Vooren JP, Turneer M, Bosmans R, Dierckx P, De Bruyn J. Specific lymphoproliferation, gamma interferon production, and serum immunoglobulin G directed against a purified 32kDa mycobacterial protein antigen (P32) in patients with active tuberculosis. Scand J Immunol 1988; 27 : 187-94.
103. Vilcek J, Klion A, Henriksen-DeStefano D, Zemtsov A, Davidson DM, Davidson M, et al. Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis. J Clin Immunol 1986; 6 : 146-51.
104. Sanchez FO, Rodriguez JI, Agudelo G, Garcia LF. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls. Infect Immun 1994; 62 : 5673-8.
105. Surcel HM, Troye-Blomberg M, Paulie S, Andersson G, Moreno C, Pasvol G, et al. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 1994; 81 : 171-6.
106. Zhang M, Gately MK, Wang E, Gong J, Wolf SF, Lu S, et al. Interleukin 12 at the site of disease in tuberculosis. J Clin Invest 1994; 93 : 1733-9.
107. Lin Y, Zhang M, Hofman FM, Gong J, Barnes PF. Absence of a prominent Th2 cytokine response in human tuberculosis. Infect Immun 1996; 64 : 1351-6.
108. Robinson DS, Ying S, Taylor IK, Wangoo V, Mitchell DM, Kay AB, et al. Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis. Am J Respir Crit Care Med 1994; 149 : 989-93.
109. Sodhi A, Gong J, Silva C, Qian D, Barnes PF. Clinical correlates of interferon gamma production in patients with tuberculosis. Clin Infect Dis 1997; 25 : 617-20.
110. Ladel CH, Szalay G, Riedel D, Kaufmann SH. Interleukin-12 secretion by Mycobacterium tuberculosis infected macrophages. Infect Immun 1997; 65 : 1936-8.
111. Cooper AM, Magram J, Ferrante J, Orme IM. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 1997; 186 : 39-45.
112. Ottenhof TH, Kumararatne D, Casanova JL. Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria. Immunol Today 1998; 19: 491-4.
113. Lowrie DB, Tascon RE, Bonato VL, Lima VM, Faccioli LH, Stavropoulos E, et al. Therapy of tuberculosis in mice by DNA vaccination. Nature 1999; 400 : 269-71.
114. McDyer JF, Hackley MN, Walsh TE, Cook JL, Seder RA. Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses. J Immunol 1997; 158 : 492-500.
115. Blanchard DK, Michelini-Norris MB, Pearson CA, Mcmillen S, Djeu JY. Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by monocytes and large granular lymphocytes stimulated with Mycobacterium avium-M.intracellulare: activation of bactericidal activity by GM-CSF. Infect Immun 1991; 59 : 2396-402.
116. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferom gamma gene-disrupted mice. J Exp Med 1993; 178 : 2243-7.
117. Jouanguy E, Altare F, Lamhamedi S, Revy P, Emile JF, Newport M, et al. Interferon-gamma-receptor deficiency in an infant with fatal bacillie Calmette-Guerin infection. N Engl J Med 1996; 335 : 1956-61
118. Zhang M, Lin Y, Iyer DV, Gong J, Abrams JS, Barnes PF. T cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect Immun 1995; 63 : 3231-4.
119. Ting LM, Kim AC., Cattamanchi A., Ernst J.D. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol 1999; 163 : 3898-906.
120. Das SD, Narayanan PR, Kolappan C, Colston MJ. The cytokine response to bacille Calmette Guerin vaccination in South India. Int J Tuberc Lung Dis 1998; 2: 836-43.
121. Kripa VJ, Prabha C, Sulochana D. Correlates of protective immune response in tuberculous pleuritis. FEMS Immunol Med Microbiol 2004; 40 : 139-45.
122. Swaminathan S, Gong J, Zhang M, Samten B, Hanna LE, Narayanan PR, et al. Cytokine production in children with tuberculous infection and disease. Clin Infect Dis 1999; 28 : 1290-3.
123. Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, et al. Tumour necrosis factor-a is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 1995; 2: 561-72.
124. Flesch E, Kaufmann, SH. Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect Immun 1990; 58 : 2675-7.
125. Garcia I, Miyazaki Y, Marchal G, Lesslauer W, Vassalli P. High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: synergistic action of TNF and IFN-gamma in the differentiation of protective granulomas. Eur J Immunol 1997; 27 : 3182-90.
126. Moreira AL, Tsenova-Berkova L, Wang J, Laochumroonvorapong P, Freeman S, Freedman VH, et al. Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. Tuberc Lung Dis 1997; 78 : 47-55.
127. Prabha C, Kripa V J, Ram Prasad M, Sulochana D. Role of TNF-a in host immune response in tuberculous pleuritis. Curr Sci 2003; 85 : 639-42.
128. Wallis RS, Amir-Tahmasseb M, Ellner JJ. Induction of interleukin -1 and tumor necrosis factor by mycobacterial proteins: the monocyte western blot. Proc Natl Acad Sci USA 1990; 87 : 3348 -52.
129. Fujiwara H, Kleinhenz ME, Wallis RS, Ellner JJ. Increased interleukin-1 production and monocyte suppressor cell activity associated with human tuberculosis. Am Rev Respir Dis 1986; 133 : 73-7.
130. Blanchard DK, Michelini-Norris MB, Friedman H, Djeu JY. Lysis of mycobacteria-infected monocytes by IL-2 activated killer cells: role of LFA-1. Cell Immunol 1989; 119 : 402-11.
131. Fenhalls G, Wong A, Bezuidenhout J, van Helden P, Bardin P, Lukey PT. In situ production of gamma interferon, interleukin-4 and tumour necrosis factor alpha mRNA in human lung tuberculous granulomas. Infect Immun 2000; 68 : 2827-36.
132. Saunders BM, Frank AA, Orme IM, Cooper AM. Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection. Infect Immun 2000; 68 : 3322-6.
133. Rojas M, Olivier M, Gros P, Barrera LF, Garcia LF. TNF-a and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages. J Immunol 1999; 162 : 6122-31.
134. Murray PJ, Wang L, Onufryk C, Tepper RI, Young RA. T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. J Immunol 1997; 158 : 315-21.
135. Toossi Z, Gogate P, Shiratsuchi H, Young T, Ellner JJ. Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions. J Immunol 1995; 154 : 465-73.
136. Dahl KE, Shiratsuchi H, Hamilton BD, Ellner JJ, Toossi Z. Selective induction of transforming growth factor β in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis. Infect Immun 1996; 64 : 399-405.
137. Ding A, Nathan CF, Graycar J, Derynck R, Stulhr DJ, Srimal S. Macrophage deactivating factor and transforming growth factor beta 1-beta 2 and beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol 1990; 145 : 940-4.
138. Ruscetti F, Varesio L, Ochoa A, Ortaldo J. Pleiotropic effects of transforming growth factor-beta on cells of the immune system. Ann N Y Acad Sci 1993; 685 : 488-500.
139. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R. Borsatti A, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998; 187 : 129-34.
140. Law KF, Jagirdar J, Weiden MD, Bodkin M, Rom WN. Tuberculosis in HIV-positive patients: cellular response and immune activation in the lung. Am J Respir Crit Care Med 1996; 153 : 1377-84.
141. Spector WG, Lykke AW. The cellular evolution of inflammatory granulomata. J Pathol Bacteriol 1966; 92 : 163-77.
142. Lopez Ramirez GM, Rom WN, Ciotoli C, Talbot A, Martiniuk F, Cronstein B, et al. Mycobacterium tuberculosis alters expression of adhesion molecules on monocytic cells. Infect Immun 1994; 62 : 2515-20.
143. Nau GJ, Guilfoile P. Chupp GL, Berman JS, Kim SJ, Kornfeld H, et al. A chemo attractant cytokine associated with granulomas in tuberculosis and silicosis. Proc Natl Acad Sci USA 1997; 94 : 6414-9.
144. Ramanathan VD, Jawahar MS, Paramasivan CN, Rajaram K, Chandrasekar K, Kumar V, et al. A histological spectrum of host responses in tuberculous Lymphadenitis. Indian J Med Res 1999; 109 : 212-20.
145. Munk ME, Emoto M. Functions of T-cell subsets and cytokines in mycobacterial infections. Eur Respir J Suppl 1995; 20 : 668s-75s.
146. Zhang Y, Broser M, Cohen H, Bodkin M, Law K, Reibman J, et al. Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components. J Clin Invest 1995; 95 : 586-92.
147. Friedland JS, Hartley JC, Hartley CG, Shattock RJ, Griffin GE. Cytokine secretion in vivo and ex vivo following chemotherapy of Mycobacterium tuberculosis infection. Trans R Soc Trop Med Hyg 1996; 90 : 199-203.
148. Ceyhan BB, Ozgun S, Celikel T, Yalcin M, Koc M. IL-8 in pleural effusion. Respir Med 1996; 90 : 215-21.
149. Rhoades ER, Cooper AM, Orme IM. Chemokine response in mice infected with Mycobacterium tuberculosis. Infect Immun 1995; 63 : 3871-7.
150. Rutledge BJ, Rayburn H, Rosenberg R, North RJ, Gladue RP, Corless CL, et al. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J Immunol 1995; 155 : 4838-43.
151. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, et al. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 1998; 187 : 601-8.
152. Lane BR, Markovitz DM, Woodford NL, Rochford R, Strieter RM, Coffey MJ. TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression. J Immunol 1999; 163 : 3653-61.
153. Sadek MI, Sada E, Toossi Z, Schwander SK, Rich EA. Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis. Am J Respir Cell Mol Biol 1998; 19 : 513-21.
154. Kurashima K, Mukaida N, Fujimura M, Yasui M, Nakazumi Y, Matsuda T, et al. Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients. Am J Respir Crit Care Med 1997; 155 : 1474-7.
155. Fraziano M, Cappelli G, Santucci M, Mariani F, Amicosante M, Casarini M, et al. Expression of CCR5 is increased in human monocyte - derived macrophages and alveolar macrophages in the course of in vivo and in vitro Mycobacterium tuberculosis infection. AIDS Res Hum Retroviruses 1999; 15 : 869-74.
156. Markowitz N, Hansen NI, Hopewell PC, Glassroth J, Kvale PA, Mangura BT, et al. Incidence of tuberculosis in the United States among HIV-infected persons. The pulmonary complications of HIV infection study group. Ann Intern Med 1997; 126 : 123-32.
157. Swaminathan S, Ramachandran R, Baskaran G, Paramasivan CN, Ramanathan U, Venkatesan P, et al. Risk of development of tuberculosis in HIV-infected patients. Int J Tuberc Lung Dis 2000; 4 : 839-44.
158. Matsuyama T, Kobayashi N, Yamamoto N. Cytokines and HIV infection: is AIDS a tumour necrosis factor disease? AIDS 1991; 5 : 1405-17.
159. Shafer RW, Edlin BR. Tuberculosis in patients infected with human immunodeficiency virus: perspective on the past decade. Clin Infect Dis 1996; 22 : 683-704.
160. Slutsker L, Castro KG, Ward JW, Dooley SW Jr. Epidemiology of extrapulmonary tuberculosis among persons with AIDS in the United States. Clin Infect Dis 1993; 16 : 513-8.
161. van der werf TS, Das PK, van Soolingen D, Yong S, van der Mark TW, van den Akker R. Sero-diagnosis of tuberculosis with A60 antigen enzyme linked immunosorbent assay. Failure in HIV-infected individuals in Ghana. Med Microbiol Immunol (Berl) 1992; 181 : 71-6.
162. Simonney N, Molina JM, Molimard M, Oksenhendler E, Perronne C, Lagrange P H. Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-Seropositive and seronegative patients. Eur J Clin Microbiol Infect Dis 1995; 14 : 883-91.
163. Colangeli R, Antinori A, Cingolani A, Ortona L, Lyashchenko K, Fadda G, et al. Humoral immune responses to multiple antigens of Mycobacterium tuberculosis in tuberculosis patients co-infected with the human immunodeficiency virus. Int J Tuberc Lung Dis 1999; 3 : 1127-31.
164. Zhang M, Gong J, Iyer DV, Jones BE, Modlin RL, Barnes PF. T cell cytokine responses in persons with tuberculosis and human immunodeficiency virus infection. J Clin Invest 1994; 94 : 2435-42.
165. Fehniger TA, Herbein G, Yu H, Para MI, Bernstein ZP, O'Brien WA, et al. Natural killer cells from HIV-1+ patients produce C-C chemokines and inhibit HIV-1 infection. J Immunol 1998; 161 : 6433-8.
166. Lin SJ, Roberts RL, Ank BJ, Nguyen QH, Thomas EK, Stiehm ER. Effect of interleukin (IL)-12 and IL-15 on activated natural killer (ANK) and antibody-dependent cellular cytotoxicity (ADCC) in HIV infection. J Clin Immunol 1998; 18 : 335-45.
167. Selvaraj P, Uma H, Reetha AM, Kurian SM, Xavier T, Prabhakar R, et al. HLA antigen profile in pulmonary tuberculosis patients, and their spouses. Indian J Med Res 1998; 107 : 155-8.
168. Sriram U, Selvaraj P, Kurian SM, Reetha AM, Narayanan PR. HLA-DR2 subtypes & immune responses in pulmonary tuberculosis. Indian J Med Res 2001; 113 : 117-24.
169. Selvaraj P, Narayanan PR, Reetha AM. Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India. Tuberc Lung Dis 1999; 79 : 221-7.
170. Selvaraj P, Narayanan PR, Reetha AM. Association of vitamin D receptor genotypes with the susceptibility to pulmonary tuberculosis in female patients and resistance in female contacts. Indian J Med Res 2000; 111 : 172-9.
171. Selvaraj P, Chandra G, Kurian SM, Reetha AM, Narayanan PR. Association of Vitamin D receptor gene variants of BsmI, ApaI and FokI polymorphisms with susceptibility or resistance to pulmonary tuberculosis. Curr Sci 2003; 84 : 1564-8.
172. Selvaraj P, Sriram U, Mathan Kurian S, Reetha AM, Narayanan PR. Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis : haplotype analysis with HLA-A, B and DR genes. Tuberculosis 2001; 81 : 335-41.
173. Selvaraj P, Chandra G, Kurian SM, Reetha AM, Charles N, Narayanan PR. NRAMPI gene polymorphism in pulmonary and spinal tuberculosis. Curr Sci 2002; 82 : 451-4.
174. Selvaraj P, Reetha A.M, Uma H, Xavier T, Janardhanam B, Prabhakar R, et al. Influence of HLA-DR and -DQ phenotypes on tuberculin reactive status in pulmonary tuberculosis patients. Tuber Lung Dis 1996; 77 : 369-73.
175. Selvaraj P, Kurian SM, Uma H, Reetha AM, Narayanan PR. Influence of non-MHC genes on lymphocyte response to Mycobacterium tuberculosis antigens and tuberculin reactive status in pulmonary tuberculosis. Indian J Med Res 2000; 112 : 86-92.
176. Selvaraj P, Uma H, Reetha A.M, Xavier T, Prabhakar R, Narayanan PR. Influence of HLA-DR2 phenotype on humoral immunity and lymphocyte response Mycobacterium tuberculosis culture filtrate antigens in pulmonary tuberculosis. Indian J Med Res 1998; 107 : 208-17.