Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin

Journal of Immunology

Volumn 183, Issue 4, 2009, Pages 2294-2302

  Swetman Andersen, Claire A ^a   Rosenkrands, Ida ^a   Olsen, Anja W ^a   Nordly, Pernille ^a   Christensen, Dennis ^a   Lang, Roland ^c   Kirschning, Carsten ^d   Gomes, Jessica M ^e   Bhowruth, Veemal ^b   Minnikin, David E ^b   Besra, Gurdyal S ^b   Follmann, Frank ^a   Andersen, Peter ^a   Agger, Else Marie ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

AG85B ESAT 6 FUSION PROTEIN; ANTIMYCOBACTERIAL AGENT; BCG VACCINE; GAMMA INTERFERON; INTERLEUKIN 2; LIPOSOME; MONOMYCOLOYL GLYCEROL; MYCOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GLYCEROL; IMMUNOLOGICAL ADJUVANT; MONOACYLGLYCEROL;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL WALL; BCG VACCINATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; ENCAPSULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TUBERCULOSIS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; IMMUNOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BCG VACCINE; CELLS, CULTURED; FEMALE; GLYCEROL; LIPOSOMES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MONOGLYCERIDES; MYCOBACTERIUM BOVIS; MYCOLIC ACIDS;

EID: 70149111330     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804091     Document Type: Article

References (32)

1. Asselineau, J. 1966. The Bacterial Lipids. Hermann, Paris.
2. Minnikin, D. E. 1982. Lipids: complex lipids, their chemistry, biosynthesis and roles. In The Biology of the Mycobacteria. C. Ratledge and J. L. Stanford (eds.). Academic Press, London, pp. 95-184.
3. Sprott, G. D., C. J. Dicaire, K. Gurnani, S. Sad, and L. Krishnan. 2004. Activation of dendritic cells by liposomes prepared from phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette-Guérin and adjuvant activity in vivo. Infect. Immun. 72: 5235-5246.
4. Geisel, R. E., K. Sakamoto, D. G. Russell, and E. R. Rhoades. 2005. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates. J. Immunol. 174: 5007-5015.
5. Rhoades, E. R., R. E. Geisel, B. A. Butcher, S. McDonough, and D. G. Russell. 2005. Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components. Tuberculosis 85: 159-176.
6. Rosenkrands, I., E. M. Agger, A. W. Olsen, K. S. Korsholm, C. S. Andersen, K. T. Jensen, and P. Andersen. 2005. Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system. Infect. Immun. 73: 5817-5826.
7. Andersen, C. S., E. M. Agger, I. Rosenkrands, J. M. Gomes, V. Bhowruth, K. J. C. Gibson, R. V. Petersen, D. E. Minnikin, G. S. Besra, and P. Andersen. 2009. A simple mycobacterial monomycolated glycerol lipid has immunostimulatory activity. J. Immunol. 182: 424-432.
8. Dobson, G., D. E. Minnikin, S. M. Minnikin, J. H. Parlett, M. Goodfellow, and M. Ridell. 1985. Systematic analysis of complex mycobacterial lipids In Chemical Methods in Bacterial Systematics. M. Goodfellow and D. E. Minnikin (eds.). Academic Press, London, pp. 237-265.
9. Bhowruth, V., D. E. Minnikin, E. M. Agger, P. Andersen, V. W. Bramwell, Y. Perrie, and G. S. Besra. 2009. Adjuvant properties of a simplified C32 monomycoloylglycerol analogue. Bioorg. Med. Chem. Lett. 19: 2029-2032.
10. Olsen, A. W., L. A. van Pinxteren, L. M. Okkels, P. B. Rasmussen, and P. Andersen. 2001. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect. Immun. 69: 2773-2778.
11. Olsen, A. W., F. Follmann, K. Jensen, P. Hojrup, R. Leah, H. Sorensen, S. Hoffmann, P. Andersen, and M. Theisen. 2006. Identification of CT521 as a frequent target of Th1 cells in patients with urogenital Chlamydia trachomatis infection. J. Infect. Dis. 194: 1258-1266.
12. Follmann, F., A. W. Olsen, K. T. Jensen, P. R. Hansen, P. Andersen, and M. Theisen. 2008. Antigenic profiling of a Chlamydia trachomatis gene-expression library. J. Infect. Dis. 197: 897-905.
13. Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162: 3749-3752.
14. Spiller, S., S. Dreher, G. Meng, A. Grabiec, W. Thomas, T. Hartung, K. Pfeffer, H. Hochrein, H. Brade, W. Bessler, H. Wagner, and C. J. Kirschning. 2007. Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J. Biol. Chem. 282: 13190-13198.
15. Billeskov, R., C. Vingsbo-Lundberg, P. Andersen, and J. Dietrich. 2007. Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1. J. Immunol. 179: 3973-3981.
16. Agger, E. M., I. Rosenkrands, J. Hansen, K. Brahimi, B. S. Vandahl, C. Aagaard, K. Werninghaus, C. Kirschning, R. Lang, D. Christensen, et al. 2008. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PLoS ONE. 3: e3116.
17. Brandt, L., M. Elhay, I. Rosenkrands, E. B. Lindblad, and P. Andersen. 2000. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect. Immun. 68: 791-795.
18. Means, T. K., S. Wang, E. Lien, A. Yoshimura, D. T. Golenbock, and M. J. Fenton. 1999. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163: 3920-3927.
19. Darrah, P. A., D. T. Patel, P. M. De Luca, R. W. Lindsay, D. F. Davey, B. J. Flynn, S. T. Hoff, P. Andersen, S. G. Reed, S. L. Morris, et al. 2007. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 13: 843-850.
20. Baldridge, J. R., P. McGowan, J. T. Evans, C. Cluff, S. Mossman, D. Johnson, and D. Persing. 2004. Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin. Biol. Ther. 4: 1129-1138.
21. Olds, G. R., L. Chedid, E. Lederer, and A. A. Mahmoud. 1980. Induction of resistance to Schistosoma mansoni by natural cord factor and synthetic lower homologues. J. Infect. Dis. 141: 473-478.
22. Pimm, M. V., R. W. Baldwin, J. Polonsky, and E. Lederer. 1979. Immunotherapy of an ascitic rat hepatoma with cord factor (trehalose-6,6′- dimycolate) and synthetic analogues. Int. J. Cancer 24: 780-785.
23. Davidsen, J., I. Rosenkrands, D. Christensen, A. Vangala, D. Kirby, Y. Perrie, E. M. Agger, and P. Andersen. 2005. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6′-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim. Biophys. Acta 1718: 22-31.
24. Hansen, J., K. T. Jensen, F. Follmann, E. M. Agger, M. Theisen, and P. Andersen. 2008. Liposome delivery of C. muridarum MOMP primes a Th1 response that protect against genital Chlamydia infection in a mouse model. J. Infect. Dis. 198: 758-767.
25. Jo, E. K., C. S. Yang, C. H. Choi, and C. V. Harding. 2007. Intracellular signalling cascades regulating innate immune responses to mycobacteria: branching out from Toll-like receptors. Cell. Microbiol. 9: 1087-1098.
26. Fremond, C. M., V. Yeremeev, D. M. Nicolle, M. Jacobs, V. F. Quesniaux, and B. Ryffel. 2004. Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J. Clin. Invest. 114: 1790-1799.
27. Nicolle, D. M., X. Pichon, A. Bouchot, I. Maillet, F. Erard, S. Akira, B. Ryffel, and V. F. Quesniaux. 2004. Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice. Lab. Invest. 84: 1305-1321.
28. Gavin, A. L., K. Hoebe, B. Duong, T. Ota, C. Martin, B. Beutler, and D. Nemazee. 2006. Adjuvant-enhanced antibody responses in the absence of Toll-like receptor signaling. Science 314: 1936-1938.
29. Su, S. B., P. B. Silver, R. S. Grajewski, R. K. Agarwal, J. Tang, C. C. Chan, and R. R. Caspi. 2005. Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J. Immunol. 175: 6303-6310.
30. Werminghaus, K., A. Babiak, O. Gross, C. Hölscher, H. Dietrich, E. M. Agger, J. Mages, A. Mocsai, H. Schoenen, K. Finger, et al. 2009. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ-Syk-Card9-dependent immune activation. J. Exp. Med. 206: 89-97.
31. Silva, C. L. 1985. Inflammation induced by mycolic acid-containing glycolipids of Mycobacterium bovis (BCG). Braz. J. Med. Biol. Res. 18: 327-335.
32. Korsholm, K. S., E. M. Agger, C. Foged, D. Christensen, J. Dietrich, C. S. Andersen, C. Geisler, and P. Andersen. 2007. The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes. Immunology 121: 216-226.