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E.M. Hiltbold, N.J. Poloso, and P.A. Roche MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse J Immunol 170 2003 1329 1338 In this study, the accumulation of cognate pMHC-II and irrelevant pMHC-II molecules as well as lipid rafts in the IS is reported. As the IS matures, relevant pMHC-II complexes are sorted to a central region, whereas irrelevant pMHC-II molecules are excluded from this area. The authors hypothesize that, at limited peptide density, irrelevant pMHCs are involved in the initial stabilization of APC-T cell contact.
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Hiltbold, E.M.1
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C. Wulfing, C. Sumen, M.D. Sjaastad, L.C. Wu, M.L. Dustin, and M.M. Davis Costimulation and endogenous MHC ligands contribute to T cell recognition Nat Immunol 3 2002 42 47
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E. Pluskota, Y. Chen, and S.E. D'Souza Src homology domain 2-containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival J Biol Chem 275 2000 30029 30036
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Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells
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P.W. Thompson, A.M. Randi, and A.J. Ridley Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells J Immunol 169 2002 1007 1013
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Cross-linking of intercellular adhesion molecule-1 induces interleukin-8 and RANTES production through the activation of MAP kinases in human vascular endothelial cells
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H. Sano, N. Nakagawa, R. Chiba, K. Kurasawa, Y. Saito, and I. Iwamoto Cross-linking of intercellular adhesion molecule-1 induces interleukin-8 and RANTES production through the activation of MAP kinases in human vascular endothelial cells Biochem Biophys Res Commun 250 1998 694 698
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C. Lawson, M. Ainsworth, M. Yacoub, and M. Rose Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism J Immunol 162 1999 2990 2996
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Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration
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J. Greenwood, C.L. Amos, C.E. Walters, P.O. Couraud, R. Lyck, B. Engelhardt, and P. Adamson Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration J Immunol 171 2003 2099 2108 By transfecting brain endothelial cells with either wild-type ICAM-1 or ICAM-1 with defective intracellular domain, the authors have shown that the effectiveness of transendothelial migration of T lymphocytes, but not their adhesion to the endothelial cells, was dependent on ICAM-1-mediated signaling leading to Rho GTPase activation. The data indicate that, in addition to adhesion, ICAM-1 induces a signal that facilitates migration of T lymphocytes across the endothelial barrier.
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ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines
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S. Etienne-Manneville, J.B. Manneville, P. Adamson, B. Wilbourn, J. Greenwood, and P.O. Couraud ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines J Immunol 165 2000 3375 3383
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Q. Wang, G.R. Pfeiffer II, and W.A. Gaarde Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells J Biol Chem 278 2003 47731 47743
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+ T cell responses
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+ T cell responses J Immunol 174 2005 3401 3407 The ability of non-professional APCs to prime and activate CTLs directly in an ICAM-1-dependent manner was shown. Resulting CTLs were capable of inhibiting tumor growth in vivo.
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J Immunol
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Jenkinson, S.R.1
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14844344816
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ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo
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C. Blank, I. Brown, A.K. Kacha, M.A. Markiewicz, and T.F. Gajewski ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo J Immunol 174 2005 3416 3420 Authors report that ICAM-1 functions as a co-stimulatory ligand at the priming stage of CTL development, but its involvement in the effector phase of anti-tumor response is limited.
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Blank, C.1
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Cooperative disengagement of Fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency
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K. Liu, S.A. Caldwell, and S.I. Abrams Cooperative disengagement of Fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency Cancer Res 65 2005 1045 1054 In this work, the mechanism of tumor progression was ultimately linked to a cooperative decrease in ICAM-1 and Fas expression on the surface of CMS4 sarcoma cells.
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Liu, K.1
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