Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum

Biochemical Journal

Volumn 447, Issue 3, 2012, Pages 353-361

  Nuttall, James M ^a   Hettema, Ewald H ^a   Watts, Donald J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Dictyostelium discoideum; Farnesyl diphosphate synthase; Mevalonate pathway; Nitrogen containing bisphosphonate drugs; Peroxisomal targeting signal; Peroxisome

Indexed keywords

ALENDRONIC ACID; AMINO ACID; BISPHOSPHONIC ACID DERIVATIVE; DIGITONIN; GERANYLTRANSFERASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DICTYOSTELIUM DISCOIDEUM; GROWTH INHIBITION; MUTAGENESIS; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ALENDRONATE; AMINO ACID SEQUENCE; CONSENSUS SEQUENCE; DICTYOSTELIUM; DIPHOSPHONATES; DRUG RESISTANCE; GERANYLTRANSTRANSFERASE; GREEN FLUORESCENT PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEROXISOMES; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 84867269341     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120750     Document Type: Article

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