Determination of the microscopic equilibrium dissociation constants for risedronate and its analogues reveals two distinct roles for the nitrogen atom in nitrogen-containing bisphosphonate drugs

Journal of Medicinal Chemistry

Volumn 51, Issue 14, 2008, Pages 4170-4178

  Hounslow, Andrea M ^a   Carran, John ^a   Brown, Richard J ^a   Rejman, Dominik ^a   Blackburn, G Michael ^a   Watts, Donald J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINOPHENYL) 1 HYDROXYETHYLIDENE 1,1 BISPHOSPHONATE; 2 (3 PIPERINIDYL) 1 HYDROXYETHYLIDENE 1,1 BISPHOSPHONATE; 2 [3' (N ETHYL)PYRIDINIUM]ETHYLIDENEBISPHOSPHONATE; ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; GERANYLTRANSFERASE; NE 11807; NE 97220; NITROGEN DERIVATIVE; RISEDRONIC ACID;

ARTICLE; DICTYOSTELIUM DISCOIDEUM; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; EQUILIBRIUM CONSTANT; NONHUMAN; PH;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; DICTYOSTELIUM; DIPHOSPHONATES; ETIDRONIC ACID; HYDROGEN-ION CONCENTRATION; MICROSCOPY; NITROGEN; PROTEOME; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 47749086627     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7015792     Document Type: Article

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