Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: Sensitivity to telaprevir (VX-950) and interferon α

Journal of Biological Chemistry

Volumn 282, Issue 31, 2007, Pages 22619-22628

  Zhou, Yi ^a   Müh, Ute ^a   Hanzelka, Brian L ^a   Bartels, Doug J ^a   Wei, Yunyi ^a   Rao, B Govinda ^a   Brennan, Debra L ^a   Tigges, Ann M ^a   Swenson, Lora ^a   Kwong, Ann D ^a   Lin, Chao ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DISEASES; MOLECULAR STRUCTURE; PATIENT TREATMENT; SUBSTITUTION REACTIONS;

CO-FACTOR PEPTIDES; REPLICON CELLS; WILD-TYPE APOENZYME;

ENZYMES;

ALPHA INTERFERON; PEGINTERFERON ALPHA2A; PROTEINASE; RIBAVIRIN; VIRUS ENZYME; VX 950;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME STRUCTURE; HEPATITIS C VIRUS; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN VARIANT; REPLICON; STRUCTURE ANALYSIS; WILD TYPE; X RAY ANALYSIS;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; ARGININE; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; INTERFERON ALFA-2A; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHENOTYPE; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RIBAVIRIN; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 34547927078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610207200     Document Type: Article

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