-
1
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
M.W. Fried, M.L. Shiffman, K.R. Reddy Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection N Engl J Med 347 2002 975 982
-
(2002)
N Engl J Med
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
2
-
-
65449171953
-
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
-
C. Hezode, N. Forestier, G. Dusheiko Telaprevir and peginterferon with or without ribavirin for chronic HCV infection N Engl J Med 360 2009 1839 1850
-
(2009)
N Engl J Med
, vol.360
, pp. 1839-1850
-
-
Hezode, C.1
Forestier, N.2
Dusheiko, G.3
-
3
-
-
77956268467
-
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre phase 2 trial
-
P.Y. Kwo, E.J. Lawitz, J. McCone Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial Lancet 376 2010 705 716
-
(2010)
Lancet
, vol.376
, pp. 705-716
-
-
Kwo, P.Y.1
Lawitz, E.J.2
McCone, J.3
-
4
-
-
65449152185
-
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
-
J.G. McHutchison, G.T. Everson, S.C. Gordon Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection N Engl J Med 360 2009 1827 1838
-
(2009)
N Engl J Med
, vol.360
, pp. 1827-1838
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
5
-
-
0032475822
-
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
-
A.U. Neumann, N.P. Lam, H. Dahari Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Science 282 1998 103 107
-
(1998)
Science
, vol.282
, pp. 103-107
-
-
Neumann, A.U.1
Lam, N.P.2
Dahari, H.3
-
6
-
-
77953013128
-
Rapid emergence of protease inhibitor resistance in hepatitis C virus
-
30ra32
-
L. Rong, H. Dahari, R.M. Ribeiro Rapid emergence of protease inhibitor resistance in hepatitis C virus Sci Transl Med 2 2010 30ra32
-
(2010)
Sci Transl Med
, vol.2
-
-
Rong, L.1
Dahari, H.2
Ribeiro, R.M.3
-
7
-
-
75149151884
-
Resistance to direct antiviral agents in patients with hepatitis C virus infection
-
C. Sarrazin, S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2010 447 462
-
(2010)
Gastroenterology
, vol.138
, pp. 447-462
-
-
Sarrazin, C.1
Zeuzem, S.2
-
8
-
-
78049527728
-
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomized, double-blind, placebo-controlled, dose-escalation trial
-
E.J. Gane, S.K. Roberts, C.A. Stedman Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomized, double-blind, placebo-controlled, dose-escalation trial Lancet 376 2010 1467 1475
-
(2010)
Lancet
, vol.376
, pp. 1467-1475
-
-
Gane, E.J.1
Roberts, S.K.2
Stedman, C.A.3
-
9
-
-
81855228070
-
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
-
S. Zeuzem, T. Asselah, P. Angus Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection Gastroenterology 141 2011 2047 2055
-
(2011)
Gastroenterology
, vol.141
, pp. 2047-2055
-
-
Zeuzem, S.1
Asselah, T.2
Angus, P.3
-
10
-
-
84860269481
-
Virologic response to an interferon-free regimen of BI 201335 and BI 207127, with and without ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: Week 12 interim results of the SOUND-C2 study
-
November 4-8, 2011; San Francisco, CA. LB-15.
-
Zeuzem S, Soriano V, Asselah T, et al. Virologic response to an interferon-free regimen of BI 201335 and BI 207127, with and without ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: week 12 interim results of the SOUND-C2 study. Presented at: 62nd Annual Meeting of the American Association of the Study of Liver Diseases; November 4-8, 2011; San Francisco, CA. LB-15.
-
Presented At: 62nd Annual Meeting of the American Association of the Study of Liver Diseases
-
-
Zeuzem, S.1
Soriano, V.2
Asselah, T.3
-
11
-
-
85171927971
-
Dual, triple, and quadruple combination treatment with a protease inhibitor (GS-9256) and a polymerase inhibitor (GS-9190) alone and in combination with ribavirin (RBV) or PegIFN/RBV for up to 28 days in treatment nave, genotype 1 HCV subjects
-
Boston, MA. LB-1
-
Zeuzem S, Buggisch P, Agarwal K, et al. Dual, triple, and quadruple combination treatment with a protease inhibitor (GS-9256) and a polymerase inhibitor (GS-9190) alone and in combination with ribavirin (RBV) or PegIFN/RBV for up to 28 days in treatment nave, genotype 1 HCV subjects. Presented at: 61st Annual Meeting of the American Association of the Study of Liver Diseases; October 30 to November 2, 2010; Boston, MA. LB-1.
-
(2010)
Presented At: 61st Annual Meeting of the American Association of the Study of Liver Diseases; October 30 to November 2
-
-
Zeuzem, S.1
Buggisch, P.2
Agarwal, K.3
-
12
-
-
85171926923
-
VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: ZENITH study, SVR12 interim analysis
-
November 4-8, 2011; San Francisco, CA. LB-14
-
Nelson DR, Gane EJ, Jacobson IM, et al. VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment-naive genotype 1 HCV patients treated for 12 weeks: ZENITH study, SVR12 interim analysis. Presented at: 62nd Annual Meeting of the American Association of the Study of Liver Diseases; November 4-8, 2011; San Francisco, CA. LB-14.
-
Presented At: 62nd Annual Meeting of the American Association of the Study of Liver Diseases
-
-
Nelson, D.R.1
Gane, E.J.2
Jacobson, I.M.3
-
13
-
-
85171934878
-
Combination therapy with BMS-790052 and BMS-650032 alone or with pegylated interferon and ribavirin (pegIFN/RBV) results in undetectable HCV RNA through 12 weeks of therapy in HCV genotype 1 null responders
-
October 30 to November 2, Boston, MA
-
Lok A, Gardiner D, Lawitz E, et al. Combination therapy with BMS-790052 and BMS-650032 alone or with pegylated interferon and ribavirin (pegIFN/RBV) results in undetectable HCV RNA through 12 weeks of therapy in HCV genotype 1 null responders. Presented at: 61st Annual Meeting of the American Association of the Study of Liver Diseases; October 30 to November 2, 2010; Boston, MA.
-
(2010)
Presented At: 61st Annual Meeting of the American Association of the Study of Liver Diseases
-
-
Lok, A.1
Gardiner, D.2
Lawitz, E.3
-
14
-
-
84872608402
-
Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders
-
November 4-8, 2011; San Francisco, CA. LB-4
-
Chayama K, Takahashi S, Kawakami Y, et al. Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders. Presented at: 62nd Annual Meeting of the American Association of the Study of Liver Diseases; November 4-8, 2011; San Francisco, CA. LB-4.
-
Presented At: 62nd Annual Meeting of the American Association of the Study of Liver Diseases
-
-
Chayama, K.1
Takahashi, S.2
Kawakami, Y.3
-
15
-
-
84870483603
-
Quadruple therapy with BMS-790052, BMS-650032 and PEG-IFN/RBV for 24 weeks results in 100% SVR12 in HCV genotype 1 null responders
-
March 30 to April 3, Berlin, Germany
-
Lok A, Gardiner D, Lawitz E, et al. Quadruple therapy with BMS-790052, BMS-650032 and PEG-IFN/RBV for 24 weeks results in 100% SVR12 in HCV genotype 1 null responders. Presented at: 2011 Annual Meeting of the European Association for the Study of the Liver; March 30 to April 3, 2011; Berlin, Germany.
-
(2011)
Presented At: 2011 Annual Meeting of the European Association for the Study of the Liver
-
-
Lok, A.1
Gardiner, D.2
Lawitz, E.3
-
17
-
-
79251561245
-
Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus
-
T. Shimakami, C. Welsch, D. Yamane Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus Gastroenterology 140 2011 667 675
-
(2011)
Gastroenterology
, vol.140
, pp. 667-675
-
-
Shimakami, T.1
Welsch, C.2
Yamane, D.3
-
18
-
-
79959381354
-
Telaprevir for retreatment of HCV infection
-
S. Zeuzem, P. Andreone, S. Pol Telaprevir for retreatment of HCV infection N Engl J Med 364 2011 2417 2428
-
(2011)
N Engl J Med
, vol.364
, pp. 2417-2428
-
-
Zeuzem, S.1
Andreone, P.2
Pol, S.3
-
19
-
-
84860302646
-
Silen-C1: Sustained virologic response (SVR) and safety of BI201335 combined with peginterferon alfa-2a and ribavirin (P/R) in treatment-nave patients with chronic genotype 1 HCV infection
-
March 30 to April 3, Berlin, Germany
-
Sulkowski MS, Ceasu E, Asselah T, et al. Silen-C1: Sustained virologic response (SVR) and safety of BI201335 combined with peginterferon alfa-2a and ribavirin (P/R) in treatment-nave patients with chronic genotype 1 HCV infection. Presented at: 2011 Annual Meeting of the European Association for the Study of the Liver; March 30 to April 3, 2011; Berlin, Germany.
-
(2011)
Presented At: 2011 Annual Meeting of the European Association for the Study of the Liver
-
-
Sulkowski, M.S.1
Ceasu, E.2
Asselah, T.3
-
20
-
-
84860302646
-
Silen-C2: Sustained virologic response (SVR) and safety of BI201335 combined with peginterferon alfa-2a and ribavirin (P/R) in chronic HCV genotype-1 patients with non-response to P/R
-
March 30 to April 3; Berlin, Germany.
-
Sulkowski MS, Bourliere M, Bronowicki JP, et al. Silen-C2: Sustained virologic response (SVR) and safety of BI201335 combined with peginterferon alfa-2a and ribavirin (P/R) in chronic HCV genotype-1 patients with non-response to P/R. Presented at: 2011 Annual Meeting of the European Association for the Study of the Liver; March 30 to April 3, 2011; Berlin, Germany.
-
(2011)
Presented At: 2011 Annual Meeting of the European Association for the Study of the Liver
-
-
Sulkowski, M.S.1
Bourliere, M.2
Bronowicki, J.P.3
-
21
-
-
78149434641
-
DEBO25 (Alispovir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
-
L. Coelmont, X. Hanoulle, U. Chatterji DEBO25 (Alispovir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A PLoS One 5 2010 e13687
-
(2010)
PLoS One
, vol.5
, pp. 13687
-
-
Coelmont, L.1
Hanoulle, X.2
Chatterji, U.3
-
22
-
-
84862210840
-
Once daily alisporivir (DEBO25) plus PegIFNalfa2A/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment nave patients
-
March 30 to April 3; Berlin, Germany
-
Flisiak R, Pawlotsky JM, Crabbé R, et al. Once daily alisporivir (DEBO25) plus PegIFNalfa2A/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment nave patients. Presented at: 2011 Annual Meeting of the European Association for the Study of the Liver; March 30 to April 3, 2011; Berlin, Germany.
-
(2011)
Presented At: 2011 Annual Meeting of the European Association for the Study of the Liver
-
-
Flisiak R, P.1
-
23
-
-
79955815806
-
Sustained virological response with 29 days of Debio 025 monotherapy in hepatitis C virus genotype 3
-
H. Patel, E.J. Heathcote Sustained virological response with 29 days of Debio 025 monotherapy in hepatitis C virus genotype 3 Gut 60 2011 879
-
(2011)
Gut
, vol.60
, pp. 879
-
-
Patel, H.1
Heathcote, E.J.2
-
24
-
-
84861537600
-
A randomized, double-blind, placebo (PLB) controlled safety and antiviral proof of concept study of miravirsen (MIR), an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 (GT1) chronic HCV infection
-
November 4-8, San Francisco, CA. LB-6
-
Janssen HL, Reesink HW, Zeuzem S, et al. A randomized, double-blind, placebo (PLB) controlled safety and antiviral proof of concept study of miravirsen (MIR), an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 (GT1) chronic HCV infection. Presented at: 62nd Annual Meeting of the American Association of the Study of Liver Diseases; November 4-8, 2011; San Francisco, CA. LB-6.
-
(2011)
Presented At: 62nd Annual Meeting of the American Association of the Study of Liver Diseases
-
-
Janssen, H.L.1
Reesink, H.W.2
Zeuzem, S.3
-
25
-
-
84860267416
-
Pegylated interferon-lambda (pegIFN-[lambda]) shows superior viral response with improved safety and tolerability versus pegIFN-[alpha]-2a in HCV patients (G1/2/3/4): EMERGE phase IIb through week 12
-
March 30 to April 3,; Berlin, Germany
-
Zeuzem S, Arora S, Bacon BR, et al. Pegylated interferon-lambda (pegIFN-[lambda]) shows superior viral response with improved safety and tolerability versus pegIFN-[alpha]-2a in HCV patients (G1/2/3/4): EMERGE phase IIb through week 12. Presented at: 2011 Annual Meeting of the European Association for the Study of the Liver; March 30 to April 3, 2011; Berlin, Germany.
-
(2011)
Presented At: 2011 Annual Meeting of the European Association for the Study of the Liver
-
-
Zeuzem, S.1
Arora, S.2
Bacon, B.R.3
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