Possible involvement of hypothalamic nucleobindin-2 in hyperphagic feeding in Tsumura Suzuki Obese Diabetes mice

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 10, 2012, Pages 1784-1793

  Miyata, Shigeo ^a,c   Yamada, Nao ^a   Kawada, Tomie ^b  

^a MUSASHINO UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetes; Hyperphagic feeding; Hypothalamus; Nucleobindin 2; Obesity

Indexed keywords

AGOUTI RELATED PROTEIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; GALANIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; NEUROMEDIN S; NEUROMEDIN U; NEUROPEPTIDE; NEUROPEPTIDE B; NEUROPEPTIDE S; NEUROPEPTIDE W; NEUROPEPTIDE Y; NUCLEOBINDIN 2; OREXIN; PROOPIOMELANOCORTIN; PROTIRELIN; UNCLASSIFIED DRUG; UROCORTIN; UROCORTIN II; UROCORTIN III;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPERLIPIDEMIA; HYPERPHAGIA; HYPOTHALAMUS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WEIGHT GAIN;

ANIMALS; CALCIUM-BINDING PROTEINS; DIABETES MELLITUS, TYPE 2; DNA-BINDING PROTEINS; HYPERPHAGIA; HYPOTHALAMUS; MALE; MICE; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; OBESITY; RNA, MESSENGER;

EID: 84867263935     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00505     Document Type: Article

References (57)

1. Srinivasan K, Ramarao P. Animal models in type 2 diabetes research: an overview. Indian J. Med. Res., 125, 451-472 (2007).
2. Suzuki W, Iizuka S, Tabuchi M, Funo S, Yanagisawa T, Kimura M, Sato T, Endo T, Kawamura H. A new mouse model of spontaneous diabetes derived from ddY strain. Exp. Anim., 48, 181-189 (1999).
3. Iizuka S, Suzuki W, Tabuchi M, Nagata M, Imamura S, Kobayashi Y, Kanitani M, Yanagisawa T, Kase Y, Takeda S, Aburada M, Takahashi KW. Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity. Exp. Anim., 54, 71-83 (2005).
4. Kawada T, Miyata S, Shimada T, Sanzen Y, Ito M, Hemmi C, Iizuka S, Suzuki W, Mihara K, Aburada M, Nakazawa M. A study of cardiovascular function in Tsumura Suzuki obese diabetes, a new model mouse of type 2 diabetes. Biol. Pharm. Bull., 33, 998-1003 (2010).
5. Hirayama I, Yi Z, Izumi S, Arai I, Suzuki W, Nagamachi Y, Kuwano H, Takeuchi T, Izumi T. Genetic analysis of obese diabetes in the TSOD mouse. Diabetes, 48, 1183-1191 (1999).
6. Miura T, Suzuki W, Ishihara E, Arai I, Ishida H, Seino Y, Tanigawa K. Impairment of insulin-stimulated GLUT4 translocation in skeletal muscle and adipose tissue in the Tsumura Suzuki obese diabetic mouse: a new genetic animal model of type 2 diabetes. Eur. J. Endocrinol., 145, 785-790 (2001).
7. Takahashi A, Tabuchi M, Suzuki W, Iizuka S, Nagata M, Ikeya Y, Takeda S, Shimada T, Aburada M. Insulin resistance and low sympathetic nerve activity in the Tsumura Suzuki obese diabetic mouse: a new model of spontaneous type 2 diabetes mellitus and obesity. Metabolism, 55, 1664-1669 (2006).
8. Mercer JG, Speakman JR. Hypothalamic neuropeptide mechanisms for regulating energy balance: from rodent models to human obesity. Neurosci. Biobehav. Rev., 25, 101-116 (2001).
9. Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science, 307, 375-379 (2005).
10. Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science, 274, 1704-1707 (1996).
11. Kudo T, Shimada T, Toda T, Igeta S, Suzuki W, Ikarashi N, Ochiai W, Ito K, Aburada M, Sugiyama K. Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity. Xenobiotica, 39, 889-902 (2009).
12. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science, 278, 135-138 (1997).
13. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature, 393, 72-76 (1998).
14. Masaki T, Yoshimichi G, Chiba S, Yasuda T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H. Corticotropin-releasing hormone-mediated pathway of leptin to regulate feeding, adiposity, and uncoupling protein expression in mice. Endocrinology, 144, 3547-3554 (2003).
15. Kyrkouli SE, Stanley BG, Leibowitz SF. Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur. J. Pharmacol., 122, 159-160 (1986).
16. Moody TW, Merali Z. Bombesin-like peptides and associated receptors within the brain: distribution and behavioral implications. Peptides, 25, 511-520 (2004).
17. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest., 107, 379-386 (2001).
18. Ida T, Mori K, Miyazato M, Egi Y, Abe S, Nakahara K, Nishihara M, Kangawa K, Murakami N. Neuromedin S is a novel anorexigenic hormone. Endocrinology, 146, 4217-4223 (2005).
19. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat. Med., 10, 1067-1073 (2004).
20. Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc. Natl. Acad. Sci. U.S.A., 100, 6251-6256 (2003).
21. Beck B, Fernette B, Stricker-Krongrad A. Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats. Biochem. Biophys. Res. Commun., 332, 859-865 (2005).
22. Mondal MS, Yamaguchi H, Date Y, Shimbara T, Toshinai K, Shimomura Y, Mori M, Nakazato M. A role for neuropeptide W in the regulation of feeding behavior. Endocrinology, 144, 4729-4733 (2003).
23. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides, 7, 1189-1192 (1986).
24. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature, 443, 709-712 (2006).
25. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 92, 573-585 (1998).
26. Morley JE, Horowitz M, Morley PM, Flood JF. Pituitary adenylate cyclase activating polypeptide (PACAP) reduces food intake in mice. Peptides, 13, 1133-1135 (1992).
27. Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature, 411, 480-484 (2001).
28. Lechan RM, Fekete C. The TRH neuron: a hypothalamic integrator of energy metabolism. Prog. Brain Res., 153, 209-235 (2006).
29. Wang C, Mullet MA, Glass MJ, Billington CJ, Levine AS, Kotz CM. Feeding inhibition by urocortin in the rat hypothalamic paraventricular nucleus. Am. J. Physiol. Regul. Integr. Comp. Physiol., 280, R473-R480 (2001).
30. Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughan J, Arias CA, Hogenesch JB, Gulyas J, Rivier J, Vale WW, Sawchenko PE. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. U.S.A., 98, 2843-2848 (2001).
31. Chen P, Lin D, Giesler J, Li C. Identification of urocortin 3 afferent projection to the ventromedial nucleus of the hypothalamus in rat brain. J. Comp. Neurol., 519, 2023-2042 (2011).
32. Starr ME, Saito H. Age-Related Increase in Food Spilling by Laboratory Mice May Lead to Significant Overestimation of Actual Food Consumption: Implications for Studies on Dietary Restriction, Metabolism, and Dose Calculations. J. Gerontol. A: Biol. Sci. Med. Sci., in press (2012).
33. Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology, 150, 662-671 (2009).
34. Beck B, Stricker-Krongrad A, Nicolas JP, Burlet C. Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behaviour of obese Zucker rats. Int. J. Obes. Relat. Metab. Disord., 16, 295-302 (1992).
35. Chronwall BM, DiMaggio DA, Massari VJ, Pickel VM, Ruggiero DA, O'Donohue TL. The anatomy of neuropeptide-Y-containing neurons in rat brain. Neuroscience, 15, 1159-1181 (1985).
36. Gray TS, Morley JE. Neuropeptide Y: anatomical distribution and possible function in mammalian nervous system. Life Sci., 38, 389-401 (1986).
37. Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, Moran TH, Bi S. Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J. Neurosci., 29, 179-190 (2009).
38. White JD, Kershaw M. Increased hypothalamic neuropeptide Y expression following food deprivation. Mol. Cell. Neurosci., 1, 41-48 (1990).
39. Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am. J. Physiol. Regul. Integr. Comp. Physiol., 285, R1030-R1036 (2003).
40. Beck B. Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos. Trans. R. Soc. Lond., 361, 1159-1185 (2006).
41. Kyrkouli SE, Stanley BG, Seirafi RD, Leibowitz SF. Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide's effects in the brain. Peptides, 11, 995-1001 (1990).
42. Corwin RL, Robinson JK, Crawley JN. Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat. Eur. J. Neurosci., 5, 1528-1533 (1993).
43. Koegler FH, York DA, Bray GA. The effects on feeding of galanin and M40 when injected into the nucleus of the solitary tract, the lateral parabrachial nucleus, and the third ventricle. Physiol. Behav., 67, 259-267 (1999).
44. Menéndez JA, Atrens DM, Leibowitz SF. Metabolic effects of galanin injections into the paraventricular nucleus of the hypothalamus. Peptides, 13, 323-327 (1992).
45. Nagase H, Bray GA, York DA. Effect of galanin and enterostatin on sympathetic nerve activity to interscapular brown adipose tissue. Brain Res., 709, 44-50 (1996).
46. Hohmann JG, Teklemichael DN, Weinshenker D, Wynick D, Clifton DK, Steiner RA. Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol. Cell. Biol., 24, 2978-2985 (2004).
47. Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology, 138, 351-355 (1997).
48. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature, 396, 670-674 (1998).
49. Skofitsch G, Jacobowitz DM, Zamir N. Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain. Brain Res. Bull., 15, 635-649 (1985).
50. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol., 319, 218-245 (1992).
51. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature, 380, 243-247 (1996).
52. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG Jr, Flier JS, Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc. Natl. Acad. Sci. U.S.A., 100, 10085-10090 (2003).
53. Mountjoy KG, Wong J. Obesity, diabetes and functions for propiomelanocortin-derived peptides. Mol. Cell. Endocrinol., 128, 171-177 (1997).
54. Stütz AM, Staszkiewicz J, Ptitsyn A, Argyropoulos G. Circadian expression of genes regulating food intake. Obesity (Silver Spring), 15, 607-615 (2007).
55. Sindelar DK, Palmiter RD, Woods SC, Schwartz MW. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides, 26, 2597-2602 (2005).
56. Akabayashi A, Levin N, Paez X, Alexander JT, Leibowitz SF. Hypothalamic neuropeptide Y and its gene expression: relation to light/ dark cycle and circulating corticosterone. Mol. Cell. Neurosci., 5, 210-218 (1994).
57. Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C, Liu Y. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A., 105, 18619-18624 (2008).