Propylbenzmethylation at Val-1(α) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(α)

Biochimica et Biophysica Acta - General Subjects

Volumn 1820, Issue 12, 2012, Pages 2044-2051

  Hu, Tao ^a   Li, Dongxia ^a   Wang, Jun ^a   Wang, Qingqing ^a   Liang, Yangui ^a,b   Su, Yanlei ^b   Ma, Guanghui ^a   Su, Zhiguo ^a   Wang, Shihua ^c  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b TIANJIN UNIVERSITY   (China)

^c FUJIAN AGRICULTURE AND FORESTRY UNIVERSITY   (China)

Author keywords

Hemoglobin; Hemoglobin based oxygen carrier; PEGylation; Propylbenzmethylation; Tetramer stability

Indexed keywords

CYSTEINE; DIMER; HEMOGLOBIN A; MALEIMIDE; PEGYLATED HEMOGLOBIN; TETRAMER; UNCLASSIFIED DRUG; VALINE;

ARTICLE; AUTOOXIDATION; DISSOCIATION CONSTANT; HYDROPHOBICITY; PRIORITY JOURNAL; PROPYLBENZMETHYLATION; PROTEIN DENATURATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN METHYLATION; PROTEIN MODIFICATION; PROTEIN PROPYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMOSTABILITY;

ADULT; ALKENES; CIRCULAR DICHROISM; HEME; HEMOGLOBINS; HUMANS; METHYLATION; OSMOTIC PRESSURE; OXYGEN; POLYETHYLENE GLYCOLS; ULTRACENTRIFUGATION; VALINE;

EID: 84867237759     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.09.013     Document Type: Article

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