PEGylation of Val-1(α) destabilizes the tetrameric structure of hemoglobin

Biochemistry

Volumn 48, Issue 3, 2009, Pages 608-616

  Hu, Tao ^a   Li, Dongxia ^a   Manjula, Belur N ^a   Brenowitz, Michael ^a   Prabhakaran, Muthuchidambaram ^b   Acharya, Seetharama A ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b The Department of Electrical and Computer Engineering   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION; HEMOGLOBIN;

ALLOSTERIC EFFECTORS; DIMER DISSOCIATION; FUNCTIONAL CHANGES; QUATERNARY STRUCTURE; STRUCTURAL ALTERATIONS; STRUCTURAL ASPECTS; TETRAMER STABILITY; TETRAMERIC STRUCTURES;

OLIGOMERS;

DIMER; HEME; HEMOGLOBIN; MACROGOL; TETRAMER; VALINE; MACROGOL DERIVATIVE; OXYGEN;

ALLOSTERISM; ARTICLE; BOHR EFFECT; CHEMICAL MODIFICATION; DISSOCIATION CONSTANT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SENSITIZATION; CHEMISTRY; CIRCULAR DICHROISM; FLUORESCENCE; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR WEIGHT; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; ULTRACENTRIFUGATION;

ALLOSTERIC REGULATION; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CIRCULAR DICHROISM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENCE; HEMOGLOBINS; HUMANS; HYDROGEN-ION CONCENTRATION; ISOELECTRIC FOCUSING; KINETICS; MOLECULAR WEIGHT; OXYGEN; POLYETHYLENE GLYCOLS; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; ULTRACENTRIFUGATION; VALINE;

EID: 59249106690     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801880y     Document Type: Article

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