Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 10, 2008, Pages 1402-1409

  Portoro I ^a   Kocsis, L ^a   Herman P ^a   Caccia, D ^b   Perrella, M ^b   Ronda, L ^b   Bruno, S ^c   Bettati, S ^c   Micalella, C ^c   Mozzarelli, A ^c   Varga, A ^d   Vas, M ^d   Lowe, K C ^e   Eke, A ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

(Hb) based oxygen carrier; Blood substitute; Haemoglobin; Protein PEGylation; Urine Hb; Vasoactivity

Indexed keywords

BLOOD SUBSTITUTE; CARBON DIOXIDE; DEOXYHEMOGLOBIN; HEMOGLOBIN A; HEMOGLOBIN BASED OXYGEN CARRIER; MACROGOL; PEGYLATED HEMOGLOBIN; PROTON; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; DRUG MECHANISM; GLOMERULUS FILTRATION; HYPERTENSION; NONHUMAN; OXIDATION; OXYGEN AFFINITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT;

AEROBIOSIS; ANAEROBIOSIS; BLOOD SUBSTITUTES; BLOOD TRANSFUSION; DEVELOPING COUNTRIES; FILTRATION; HEMOGLOBINS; HUMANS; ISOTONIC SOLUTIONS; KIDNEY; KINETICS; MODELS, MOLECULAR; OXYGEN; OXYHEMOGLOBINS; POLYETHYLENE GLYCOLS; PROTEIN BINDING; PROTEIN CONFORMATION;

RATTUS;

EID: 52049113672     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2008.03.005     Document Type: Article

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