Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate

Biochemical Journal

Volumn 392, Issue 3, 2005, Pages 555-564

  Hu, Tao ^a   Prabhakaran, Muthuchidambaram ^b   Acharya, Seetharama A ^a   Manjula, Belur N ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b The Department of Electrical and Computer Engineering   (United States)

Author keywords

Colloidal osmotic pressure (COP); PEGylated Hb; PEGylation; Reductive alkylation; Thiolation mediated maleimide chemistry; Viscosity

Indexed keywords

ALKYLATION; COLLOIDS; OSMOSIS; OXYGEN; PROTEINS; VISCOSITY;

COLLOIDAL OSMOTIC PRESSURE (COP); PEGYLATED HB; PEGYLATION;

POLYETHYLENE GLYCOLS;

HEMOGLOBIN; MACROGOL; MALEIMIDE;

ALKYLATION; ALLOSTERISM; ARTICLE; CHEMISTRY; CIRCULAR DICHROISM; CONJUGATION; MOLECULAR WEIGHT; ONCOTIC PRESSURE; OXYGEN AFFINITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; VISCOSITY;

HEMOGLOBIN A; HUMANS; KINETICS; MODELS, MOLECULAR; OXYGEN; POLYETHYLENE GLYCOLS; PROTEIN BINDING; SOLUTIONS;

EID: 29644434820     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050663     Document Type: Article

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