Hemoglobin-based oxygen carriers for reversing hypotension and shock: NO way, no how?

Anesthesiology

Volumn 114, Issue 5, 2011, Pages 1016-1018

  Levy, Jerrold H ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN DERIVATIVE; MP4OX; NITRIC OXIDE; PERFLUORO COMPOUND; RECOMBINANT HEMOGLOBIN; UNCLASSIFIED DRUG;

DRUG EFFICACY; EDITORIAL; HIP ARTHROPLASTY; HUMAN; HYPOTENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SHOCK; SPINAL ANESTHESIA; SURGICAL PATIENT;

EID: 79955412524     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318215e20b     Document Type: Editorial

References (21)

1. Weiskopf RB: Hemoglobin-based oxygen carriers: Compassionate use and compassionate clinical trials. Anesth Analg 2010; 110:659-62.
2. Silverman TA, Weiskopf RB, Planning Committee and the Speakers: Hemoglobin-based oxygen carriers: Current status and future directions. ANESTHESIOLOGY 2009; 111:946-63.
3. Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine. Second of two parts-blood conservation. N Engl J Med 1999; 340:525-33. (Pubitemid 29093289)
4. Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine. First of two parts-blood transfusion. N Engl J Med 1999; 340:438-47. (Pubitemid 29084776)
5. Olofsson CI, Górecki AZ, Dirksen R, Kofranek I, Majewski JA, Mazurkiewicz T, Jahoda D, Fagrell B, Keipert PE, Hardiman YJ, Levy H: Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: A randomized, doubleblind, multicenter study. ANESTHESIOLOGY 2011; 114:1048-63.
6. Estep T, Bucci E, Farmer M, Greenburg G, Harrington J, Kim HW, Klein H, Mitchell P, Nemo G, Olsen K, Palmer A, Valeri CR, Winslow R: Basic science focus on blood substitutes: A summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006. Transfusion 2008; 48:776-82. (Pubitemid 351430350)
7. Levy JH: Hemoglobin-based oxygen-carrying solutions: Close but still so far. ANESTHESIOLOGY 2000; 92:639-41. (Pubitemid 30130163)
8. Loscalzo J: Nitric oxide binding and the adverse effects of cell-free hemoglobins: What makes us different from earthworms. J Lab Clin Med 1997; 129:580-3.
9. Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM: Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: A meta-analysis. JAMA 2008; 299: 2304-12. (Pubitemid 351724397)
10. Hess JR, MacDonald VW, Brinkley WW: Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 1993; 74:1769-78. (Pubitemid 23133473)
11. Steudel W, Hurford WE, Zapol WM: Inhaled nitric oxide: Basic biology and clinical applications. ANESTHESIOLOGY 1999; 91:1090-121. (Pubitemid 29466545)
12. Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM: Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. ANESTHESIOLOGY 2010; 112:586-94.
13. Silverman TA, Weiskopf RB: Hemoglobin-based oxygen carriers: Current status and future directions. Transfusion 2009; 49:2495-515.
14. Olofsson C, Ahl T, Johansson T, Larsson S, Nellgård P, Ponzer S, Fagrell B, Przybelski R, Keipert P, Winslow N, Winslow RM: A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified Hemoglobin (Hemospan) in patients undergoing major orthopedic surgery. ANESTHESIOLOGY 2006; 105:1153-63. (Pubitemid 44808579)
15. Bowersox JC, Hess JR: Trauma and military applications of blood substitutes. Artif Cells Blood Substit Immobil Biotechnol 1994; 22:145-57. (Pubitemid 24202372)
16. Levy JH, Goodnough LT, Greilich PE, Parr GV, Stewart RW, Gratz I, Wahr J, Williams J, Comunale ME, Doblar D, Silvay G, Cohen M, Jahr JS, Vlahakes GJ: Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial. J Thorac Cardiovasc Surg 2002; 124:35-42.
17. Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ: The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: Results of a multicenter, randomized, single-blinded trial. Anesth Analg 2002; 94:799-808. (Pubitemid 34263719)
18. Lamy ML, Daily EK, Brichant JF, Larbuisson RP, Demeyere RH, Vandermeersch EA, Lehot JJ, Parsloe MR, Berridge JC, Sinclair CJ, Baron JF, Przybelski RJ: Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. The DCLHb Cardiac Surgery Trial Collaborative Group. ANESTHESIOLOGY 2000; 92:646-56. (Pubitemid 30130166)
19. Kilbourn RG, Szabó C, Traber DL: Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies. Shock 1997; 7:235-46. (Pubitemid 127654274)
20. Dzavík V, Cotter G, Reynolds HR, Alexander JH, Ramanathan K, Stebbins AL, Hathaway D, Farkouh ME, Ohman EM, Baran DA, Prondzinsky R, Panza JA, Cantor WJ, Vered Z, Buller CE, Kleiman NS, Webb JG, Holmes DR, Parrillo JE, Hazen SL, Gross SS, Harrington RA, Hochman JS, SHould we inhibit nitric Oxide synthase in Cardiogenic shocK 2 (SHOCK-2) investigators: Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: A phase II dose-ranging study. Eur Heart J 2007; 28:1109-16. (Pubitemid 47343883)
21. Tsuda A, Tanaka KA, Huraux C, Szlam F, Sato N, Yamaguchi K, Levy JH: The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery. Anesth Analg 2001; 93:1453-9 (Pubitemid 33111668)