Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a Guinea pig model

Toxicological Sciences

Volumn 127, Issue 2, 2012, Pages 567-581

  Baek, Jin Hyen ^a   Zhou, Yipin ^b   Harris, David R ^b   Schaer, Dominik J ^a   Palmer, Andre F ^c   Buehler, Paul W ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b The Ohio State University   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Hemoglobin; Oxygen therapeutic; Pharmacokinetics pharmacodynamics; Polymerized hemoglobin; Red blood cell substitute; Toxicity; Transfusion medicine

Indexed keywords

CREATININE; GLUTARALDEHYDE; HEMOGLOBIN; OXYGEN; POLYMER; POLYMERIZED BOVINE HEMOGLOBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; EXCHANGE BLOOD TRANSFUSION; EXPERIMENTAL GUINEA PIG; HISTOPATHOLOGY; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATION;

BOVINAE; CAVIA;

EID: 84861466881     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs109     Document Type: Article

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