The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 259-267

  Tukulula, Matshawandile ^a   Little, Susan ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c   Wan, Baojie ^d   Franzblau, Scott G ^d   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF SAN FRANCISCO   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antimycobacterial; Antiplasmodial; Arylamino quinoline tetrazoles; Physico chemical properties

Indexed keywords

4 [(1 TERT BUTYL 1H TETRAZOL 5 YL)(PIPERIDIN 1 YL)METHYL] 6 METHOXYQUINOLINE; ANTIMALARIAL AGENT; N [(1 TERT BUTYL 1H TETRAZOL 5 YL)(6 METHOXYQUINOLIN 4 YL)METHYL] N ETHYLETHANAMINE; QUINOLINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; COMPUTER MODEL; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; GROWTH INHIBITION; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; PLASMODIUM FALCIPARUM;

AMINOQUINOLINES; ANTIPROTOZOAL AGENTS; ANTITUBERCULAR AGENTS; BIOLOGICAL ASSAY; BLOOD-BRAIN BARRIER; COMPUTER SIMULATION; DRUG DESIGN; ERYTHROCYTES; HUMANS; INHIBITORY CONCENTRATION 50; MEFLOQUINE; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; QUININE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 84867237053     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.047     Document Type: Article

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