Heme oxygenase inhibition by 2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone

Chemical Biology and Drug Design

Volumn 75, Issue 1, 2010, Pages 68-90

  Roman, Gheorghe ^a   Rahman, Mona N ^a   Vukomanovic, Dragic ^a   Jia, Zongchao ^a   Nakatsu, Kanji ^a   Szarek, Walter A ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Azole based inhibitors; Carbon monoxide; Heme; Heme oxygenase; Heme oxygenase inhibitor complex; Structure activity relationship; X ray crystallography

Indexed keywords

2 BUTANONE; 4 PHENYL 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANONE; ALCOHOL DERIVATIVE; BENZENE DERIVATIVE; HEME; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; IMIDAZOLE; KETONE DERIVATIVE; PYRROLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; MALE; MOLECULAR INTERACTION; MOLECULAR STABILITY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

CRYSTALLOGRAPHY, X-RAY; DIOXOLANES; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; HYDROPHOBICITY; IMIDAZOLES; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; TRIAZOLES; X-RAYS;

EID: 71449115481     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00909.x     Document Type: Article

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