Genes and networks regulating cardiac development and function in flies: Genetic and functional genomic approaches

Briefings in Functional Genomics

Volumn 11, Issue 5, 2012, Pages 366-374

  Seyres, Denis ^a   Röder, Laurence ^a   Perrin, Laurent ^a  

^a Aix Marseille university   (France)

Author keywords

Cardiac function; Cardiovascular diseases; Gene regulatory network; Genome wide genetic screens; Heart differentiation

Indexed keywords

BETA GALACTOSIDASE; MEMBRANE PROTEIN; RNA; TRANSCRIPTION FACTOR;

ARTICLE; CARDIOVASCULAR SYSTEM; DIPTERA; DROSOPHILA; FUNCTIONAL GENOMICS; GENE IDENTIFICATION; GENE INTERACTION; GENETIC REGULATION; GENETIC SCREENING; HEART DEVELOPMENT; HEART DISEASE; HEART FUNCTION; INSECT GENETICS; NONHUMAN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME, INSECT; MYOCYTES, CARDIAC; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 84867130757     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/els028     Document Type: Article

References (56)

1. Rizki TM. The circulatory system and associated cells tissues. In: Ashburner M, Wright TR (eds). The genetics and biology of Drosophila, Vol. 2b. London: Academic Press, 1978:397-452.
2. Rugendorff A, Younossi-Hartenstein A, Hartenstein V. Embryonic origin and differentiation of the Drosophila heart. Roux's ArchDev Biol 1994;203:266-80.
3. Reim I, Frasch M. Genetic and genomic dissection of cardiogenesis in the Drosophila model. Pediatr Cardiol 2010; 31(3):325-34.
4. Tao Y, Schulz RA. Heart development in Drosophila. Semin Cell Dev Biol 2007;18(1):3-15.
5. Hartenstein V. Atlas of Drosophila development. In: The Development of Drosophila melanogaster, supplement. Plainview N.Y.: Cold Spring Harbor Laboratory Press, 1993.
6. Azpiazu N, Frasch M. Tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 1993;7(7B):1325-40.
7. Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 1993;118(3):719-29.
8. Bodmer R, Frasch M. Genetic determination of Drosophila heart development. In: Rosenthal N, Harvey RP (eds). Heart Development. San Diego, California: Academic Press, 1999:65-90.
9. Komuro I, Izumo S. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. ProcNatl Acad SciUSA 1993;90(17):8145-9.
10. Lints TJ, Parsons LM, Hartley L, et al. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 1993; 119(3):969.
11. Cripps RM, Olson EN. Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 2002;246(1):14-28.
12. Olson EN. Gene regulatory networks in the evolution and development of the heart. Science 2006;313(5795):1922-7.
13. Lalevée N, Monier B, Senatore S, et al. Control of cardiac rhythm by ORK1, a Drosophila two-pore domain potassium channel. Curr Biol 2006;16(15):1502-8.
14. Medioni C, Senatore S, Salmand PA, et al. The fabulous destiny of the Drosophila heart. Curr Opin Genet Dev 2009; 19(5):518-25.
15. Nishimura M, Ocorr K, Bodmer R, et al. Drosophila as a model to study cardiac aging. Exp Gerontol 2011; 46(5):326-30.
16. Ocorr K, Perrin L, Lim HY, et al. Genetic control of heart function and aging in Drosophila. Trends Cardiovasc Med 2007; 17(5):177-82.
17. Ocorr K, Reeves NL, Wessells RJ, et al. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci USA 2007;104(10):3943-8.
18. Wessells RJ, Fitzgerald E, Cypser JR, et al. Insulin regulation of heart function in aging fruit flies. Nat Genet 2004; 36(12):1275-81.
19. Wolf MJ, Rockman HA. Drosophila, genetic screens, and cardiac function. Circ Res 2011;109(7):794-806.
20. Bryantsev AL, Cripps RM. Cardiac gene regulatory networks in Drosophila. Biochim Biophys Acta 2009; 1789(4):343-53.
21. Occor K, Perrin L, Lim HY, Quian L, Bodmer R. Genetic control of heart function and aging in Drosophila. Trends CardiovascMed 2007;17(5):177-82.
22. Kim YO, Park SJ, Balaban RS, et al. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Proc Natl Acad Sci USA 2004;101(1):159-64.
23. Han Z, Yi P, Li X, Olson EN. Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. Development 2006;133(6):1175-82.
24. Wang J, Tao Y, Reim I, et al. Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Mol Cell Biol 2005;25(10):4200-10.
25. Tao Y, Christiansen AE, Schulz RA. Second chromosome genes required for heart development in Drosophila melanogaster. Genesis 2007;45(10):607-17.
26. Tao Y, Wang J, Tokusumi T, et al. Requirement of the LIM homeodomain transcription factor tailup for normal heart and hematopoietic organ formation in Drosophila melanogaster. Mol Cell Biol 2007;27(11):3962-9.
27. Mann T, Bodmer R, Pandur P. The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis. Development 2009;136(2):317-26.
28. Yi P, Han Z, Li X, Olson EN. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science 2006;313(5791):1301-3.
29. King IN, Qian L, Liang J, et al. A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Dev Cell 2011;20(4):497-510.
30. Kwon C, Han Z, Olson EN, et al. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. ProcNatl Acad SciUSA 2005;102(52):18986-91.
31. Sokol NS, Ambros V. Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. Genes Dev 2005;19(19):2343-54.
32. Zhao Y, Ransom JF, Li A, et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007;129(2):303-17.
33. Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005;436(7048):214-20.
34. Senatore S, Rami Reddy V, Semeriva M, et al. Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. PLoSGenet 2010;6(9):pii: e1001088.
35. Qian L, Wythe JD, Liu J, et al. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. JCell Biol 2011;193(7):1181-96.
36. Fink M, Callol-Massot C, Chu A, et al. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 2009;46(2):101-13.
37. Grossman TR, Gamliel A, Wessells RJ, et al. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet 2011; 7(11):e1002344.
38. Wolf MJ, Amrein H, Izatt JA, et al. Drosophila as a model for the identification of genes causing adult human heart disease. ProcNatl Acad SciUSA 2006;103(5):1394-9.
39. Yu L, Lee T, Lin N, et al. Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet 2010; 6(5):e1000969.
40. Kim IM, Wolf MJ, Rockman HA. Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res 2010;106(7):1233-43.
41. Casad ME, Yu L, Daniels JP, et al. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Mol Genet Genomics 2012;287(4):351-60.
42. Neely GG, Kuba K, Cammarato A, et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell 2010;141(1):142-53.
43. Akasaka T, Ocorr K. Drug discovery through functional screening in the Drosophila heart. Methods Mol Biol 2009; 577:235-49.
44. Calzolari D, Bruschi S, Coquin L, et al. Search algorithms as a framework for the optimization of drug combinations. PLoSComput Biol 2008;4(12):e1000249.
45. Pandey UB, Nichols CD. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev 2011;63(2):411-36.
46. Zeitouni B, Senatore S, Severac D, et al. Signalling pathways involved in adult heart formation revealed by gene expression profiling in Drosophila. PLoS Genet 2007; 3(10):1907-21.
47. Molina MR, Cripps RM. Ostia, The inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells. Mech Dev 2001;109(1):51-9.
48. Monier B, Astier M, Semeriva M, et al. Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart. Development 2005; 132(23):5283-93.
49. Shah AP, Nongthomba U, Kelly Tanaka KK, et al. Cardiac remodeling in Drosophila arises from changes in actin gene expression and from a contribution of lymph gland-like cells to the heart musculature. Mech Dev 2011; 128(3-4):222-33.
50. Junion G, Bataille L, Jagla T, et al. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Genes Dev 2007;21(23):3163-80.
51. Junion G, Spivakov M, Girardot C, et al. A transcription factor collective defines cardiac cell fate and reflects lineage history. Cell 2012;148(3):473-86.
52. Salmand PA, Iche-Torres M, Perrin L. Tissue-specific cell sorting from Drosophila embryos: application to gene expression analysis. Fly (Austin) 2011;5(3):261-5.
53. Bryantsev AL, Cripps RM. Purification of cardiac cells from Drosophila embryos. Methods 2012;56(1):44-9.
54. Bonn S, Zinzen RP, Girardot C, et al. Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. Nat Genet 2012;44(2):148-56.
55. Steiner FA, Talbert PB, Kasinathan S, et al. Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling. Genome Res 2012;22(4):766-77.
56. Cammarato A, Ahrens CH, Alayari NN, et al. A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS One 2011;6(4):e18497.