A single mutation in framework 2 of the heavy variable domain improves the properties of a diabody and a related single-chain antibody

Journal of Molecular Biology

Volumn 423, Issue 3, 2012, Pages 337-350

  Rodríguez Rodríguez, Everardo Remi ^a   Ledezma Candanoza, Luis M ^a   Contreras Ferrat, Luis Gabriel ^a   Olamendi Portugal, Timoteo ^a   Possani, Lourival D ^a   Becerril, Baltazar ^a   Riaño Umbarila, Lidia ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

diabody; directed evolution; neutralization; phage display; scorpion toxin

Indexed keywords

DIABODY 6009F; DIABODY D4; NOXIUSTOXIN; SCFV 6009F ANTIBODY; SCFV LER ANTIBODY; SCFV LR ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOPANNING; CONTROLLED STUDY; ENVENOMATION; FEMALE; GENE MUTATION; GENE REARRANGEMENT; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; TEMPERATURE;

CENTRUROIDES NOXIUS; MUS; SCORPIONES;

EID: 84867072214     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.07.007     Document Type: Article

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