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Volumn 57, Issue , 2012, Pages 162-175

Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4- morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents

(9) Zhu, Wufu a,b Liu, Yajing a Zhai, Xin a Wang, Xiao a Zhu, Yan a Wu, Di a Zhou, Hongyu a Gong, Ping a Zhao, Yanfang a

a SHENYANG PHARMACEUTICAL UNIVERSITY (China)

b JIANGXI SCIENCE AND TECHNOLOGY NORMAL UNIVERSITY (China)

Author keywords

2 Hydrazinyl 4 morpholinothieno 3,2 d pyrimidine; 3D QSAR; CoMFA; CoMSIA; Cytotoxic activity; Synthesis

Indexed keywords

2 HYDRAZINYL 4 MORPHOLINOTHIENO[3,2 D]PYRIMIDINE DERIVATIVE; 4 [2 [2 [[1 (3 FLUOROBENZYL) 1H INDOL 3 YL]METHYLENE]HYDRAZINYL]THIENO[3,2 D]PYRIMIDIN 4 YL]MORPHOLINE; ANTINEOPLASTIC AGENT; PICTILISIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; LIVER CANCER; LUNG CANCER; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STOMACH CANCER; THREE DIMENSIONAL IMAGING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOTOXINS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STATIC ELECTRICITY;

EID: 84867063736 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.09.002 Document Type: Article

Times cited : (32)

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