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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5952-5956

Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors

(12) Ni, Yike a Gopalsamy, Ariamala a Cole, Derek b Hu, Yonghan a Denny, Rajiah a Ipek, Manus a Liu, Julie a Lee, Julie a Hall, J Perry a Luong, Michael a Telliez, Jean Baptiste a Lin, Lih Ling a

a PFIZER INC (United States)

b Takeda San Diego Inc (United States)

Author keywords

Thieno 3,2 d pyrimidine; Tpl2 kinase

Indexed keywords

PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; THIENO[3,2 D]PYRIMIDINE DERIVATIVE; TUMOR PROGRESSION LOCUS 2 KINASE; TUMOR PROGRESSION LOCUS 2 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MAP KINASE KINASE KINASES; MICROSOMES, LIVER; MOLECULAR TARGETED THERAPY; MONOCYTES; NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 80052596760 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.069 Document Type: Article

Times cited : (32)

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