3D pharmacophore model-assisted discovery of novel CDC7 inhibitors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 10, 2011, Pages 720-723

  Lindvall, Mika ^a   McBride, Christopher ^a   McKenna, Maureen ^a   Gesner, Thomas G ^a   Yabannavar, Asha ^a   Wong, Kent ^a   Lin, Song ^a   Walter, Annette ^a   Shafer, Cynthia M ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

CDC7; homology model; kinase; lead generation; pharmacophore model; structure activity relationship

Indexed keywords

2 (HETEROARYL) 6,7 DIHYDROTHIENO[3,2 C]PYRIDIN 4(5H) ONE; CDC7 PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; PHARMACOPHORE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STRUCTURE ACTIVITY RELATION;

EID: 80054770024     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200029w     Document Type: Article

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