Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

Acta Pharmaceutica

Volumn 57, Issue 4, 2007, Pages 395-411

  El Gazzar, Abdel Rahman B A ^a   Hussein, Hoda A R ^a   Hafez, Hend N ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Analgesic; Anti inflammatory; Thienopyridines; Thienopyrimidines; Thieno 2,3 d 1,3 thiazine; Triazolothienopyrimidine; Ulcerogenic activity

Indexed keywords

1 (3 AMINO 4 IMINO 6 ISOPROPYL 3,4 DIHYDRO THIENO[2,3 D]PYRIMIDIN 5 YL) PROPAN 2 ONE; 1 (4 AMINO 6 ISOPROPYL THIENO[2,3 D]PYRIMIDIN 5 YL) PROPAN 2 ONE; 1 (4 IMINO 6 ISOPROPYL 2 THIOXO 1,4 DIHYDRO 2H THIENO[2,3 D][1,3]THIAZIN 5 YL) PROPAN 2 ONE; 1 (6 ISOPROPYL 2,4 DITHIOXO 1,2,3,4 TETRAHYDRO THIENO[2,3 D]PYRIMIDIN 5 YL) PROPAN 2 ONE; 1,7 DIPHENYL 6 METHYL THIENO[2,3 D][1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 5 ONE 3 ETHYLCARBOXYLATE; 2 AMINO 4 METHYL 5 PHENYL THIOPENE 3 ETHYLCARBOXYLATE; 3 ACETYL 1 (4 CHLOROPHENYL) 7 PHENYL 6 METHYL THIENO[2,3 D][1,2,4]TRIAZOLO [4,3 A]PYRIMIDIN 5 ONE; 3 ACETYL 1 (4 METHOXYPHENYL) 7 PHENYL 6 METHYL THIENO[2,3 D][1,2,4]TRIAZOLO [4,3 A]PYRIMIDIN 5 ONE; 3 ACETYL 1 (4 NITROPHENYL) 7 PHENYL 6 METHYL THIENO[2,3,D][1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 5 ONE; 4 AMINO 6 HYDROXY 2 ISOPROPYL 3 (2 OXO PROPYL) THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 AMINO 6 ISOPROPYL 5 (2 OXO PROPYL) 1H THIENO[2,3 D]PYRIMIDIN 2 ONE; 4 AMINO 6 ISOPROPYL 5 (2 OXO PROPYL) 1H THIENO[2,3 D]PYRIMIDINE 2 THIONE; 4,6 DIAMINO 2 ISOPROPYL 3 (2 OXO PROPYL) THIENO[2,3 D]PYRIDINE 5 CARBONITRILE; 5 METHYL 6 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDRO THIENO[2,3 D[PYRIMIDIN 4 ONE; 6 ISOPROPYL 2 METHYL 5 (2 OXO PROPYL) 3H THIENO[2,3 D]PYRIMIDIN 4 ONE; 6 ISOPROPYL 5 (2 OXO PROPYL) 3H THIENO[2,3 D]PYRIMIDIN 4 ONE; 6 METHYL 1,3,7 TRIPHENYL THIENO[2,3 D][1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 5 ONE; 7 PHENYL 6 METHYL 1 (4 TOLLYL) THIENO[2,3 D][1,2,4]TRIAZOLO[4,3 A]PYRIMIDIN 5 ONE 3 ETHYLCARBOXYLATE; ACETONE 1 (2 AMINO 5 ISOPROPYL THIOPHENE 3 CARBONITRILE); ACETONITRILE DERIVATIVE; ACETYLSALICYLIC ACID; CARBOXYLIC ACID DERIVATIVE; FUNCTIONAL GROUP; INDOMETACIN; N [3 CYANO 5 ISOPROPYL 4 (2 OXO PROPYL) THIOPHEN 2 YL] ACETIMIDIC ACID ETHYL ESTER; N [3 CYANO 5 ISOPROPYL 4 (2 OXO PROPYL) THIOPHEN 2 YL] FORMAMIDIC ACID ETHYL ESTER; N [3 CYANO 5 ISOPROPYL 4 (2 OXO PROPYL) THIOPHEN 2 YL] FORMAMIDINE; THIENOPYRIDINE DERIVATIVE; THIENO[2,3 D]PYRIMIDIN 4 ONE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; RAT; SYNTHESIS; ULCEROGENESIS;

EID: 37749054898     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-007-0032-6     Document Type: Article

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