Synthesis and cytotoxicity studies of novel 2-hydrazonylpyrido[2,3-b] pyrazin-3(4H)-ones

Archiv der Pharmazie

Volumn 345, Issue 1, 2012, Pages 49-56

  Zhang, Guogang ^a   Liu, Yajing ^a   Wang, Shuobing ^a   Zhou, Chuan ^a   Huang, Qingchang ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

2 Hydrazonylpyrido 2,3 b pyrazin 3(4H) ones; Anticancer activity; Apoptosis

Indexed keywords

2 [2 (2 HYDROXY 3 (2 METHYLALLYL)BENZYLIDENE)HYDRAZINYL]4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (2,4 DIHYDROXYBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (2,4 DIHYDROXYBENZYLIDENE)HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXY 5 ISOPROPYLBENZYLIDENE)HYDRAZINYL] 4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXY 5 METHYLBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXY 5 METHYLBENZYLIDENE)HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXY 5 METHYLBENZYLIDENE)HYDRAZINYL] 4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 5 TERT BUTYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 5 TERT BUTYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3 ALLYL 5 TERT BUTYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3,5 DI TERT BUTYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (3,5 DI TERT BUTYL 2 HYDROXYBENZYLIDENE)HYDRAZINYL]4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (4 CHLORO 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 (4 CHLORO 2 HYDROXYBENZYLIDENE)HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 [2 HYDROXY 3 (2 METHYLALLYL)BENZYLIDENE]HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL)PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 [2 HYDROXY 3 (2 METHYLALLYL)BENZYLIDENE]HYDRAZINYL] 4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 [4 (4 CHLOROBENZYLOXY) 2 HYDROXYBENZYLIDENE]HYDRAZINYL] 4 PHENYLPYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 2 [2 [4 (BENZYLOXY) 2 HYDROXYBENZYLIDENE]HYDRAZINYL] 4 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 4 (4 METHOXYPHENYL) 2 [2 (2,3,4 TRIHYDROXYBENZYLIDENE)HYDRAZINYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; 4 PHENYL 2 [2 (2,3,4 TRIHYDROXYBENZYLIDENE)HYDRAZINYL]PYRIDO[2,3 B]PYRAZIN 3 (4H)ONE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CHEMISTRY TECHNIQUES, SYNTHETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862909090     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100103     Document Type: Article

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