메뉴 건너뛰기




Volumn 24, Issue 5, 2012, Pages 412-422

Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting

Author keywords

Aging; Inflammation; Obesity; Sarcopenia

Indexed keywords

ATROGIN 1; CASPASE; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MYOD PROTEIN; MYOGENIN; PROTEASOME; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84866993612     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.3275/8464     Document Type: Review
Times cited : (113)

References (124)
  • 1
    • 0030968884 scopus 로고    scopus 로고
    • Sarcopenia: Origins and clinical relevance
    • Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997; 127 (Suppl 5): 990S-1S.
    • (1997) J Nutr , vol.127 , Issue.SUPPL. 5
    • Rosenberg, I.H.1
  • 2
    • 0036246979 scopus 로고    scopus 로고
    • Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    • Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002; 50: 889-96.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 889-896
    • Janssen, I.1    Heymsfield, S.B.2    Ross, R.3
  • 3
    • 0033927851 scopus 로고    scopus 로고
    • Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr
    • Janssen I, Heymsfield SB, Wang ZM, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol 2000; 89: 81-8.
    • (2000) J Appl Physiol , vol.89 , pp. 81-88
    • Janssen, I.1    Heymsfield, S.B.2    Wang, Z.M.3    Ross, R.4
  • 4
    • 0036904691 scopus 로고    scopus 로고
    • Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
    • Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 2002; 57: M772-7.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57
    • Iannuzzi-Sucich, M.1    Prestwood, K.M.2    Kenny, A.M.3
  • 6
    • 0018865423 scopus 로고
    • Strength of isometric and isokinetic contractions: Knee muscles of men aged 20 to 86
    • Murray MP, Gardner GM, Mollinger LA, Sepic SB. Strength of isometric and isokinetic contractions: knee muscles of men aged 20 to 86. Phys Ther 1980; 60: 412-9.
    • (1980) Phys Ther , vol.60 , pp. 412-419
    • Murray, M.P.1    Gardner, G.M.2    Mollinger, L.A.3    Sepic, S.B.4
  • 7
    • 0032522560 scopus 로고    scopus 로고
    • Epidemiology of sarcopenia among the elderly in New Mexico
    • Baumgartner RN, Koehler KM, Gallagher D et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755-63.
    • (1998) Am J Epidemiol , vol.147 , pp. 755-763
    • Baumgartner, R.N.1    Koehler, K.M.2    Gallagher, D.3
  • 9
    • 0030731486 scopus 로고    scopus 로고
    • Falls, injuries due to falls, and the risk of admission to a nursing home
    • Tinetti ME, Williams CS. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med 1997; 337: 1279-84.
    • (1997) N Engl J Med , vol.337 , pp. 1279-1284
    • Tinetti, M.E.1    Williams, C.S.2
  • 10
    • 0028805312 scopus 로고
    • Strength is a major factor in balance, gait, and the occurrence of falls
    • Wolfson L, Judge J, Whipple R, King M. Strength is a major factor in balance, gait, and the occurrence of falls. J Gerontol A Biol Sci Med Sci 1995; 50 (Spec No): 64-7.
    • (1995) J Gerontol A Biol Sci Med Sci , vol.50 , Issue.SPEC. NO , pp. 64-67
    • Wolfson, L.1    Judge, J.2    Whipple, R.3    King, M.4
  • 11
    • 77951940097 scopus 로고    scopus 로고
    • Greater lean tissue and skeletal muscle mass are associated with higher bone mineral content in children
    • PMCID:2886077
    • Dorsey KB, Thornton JC, Heymsfield SB, Gallagher D. Greater lean tissue and skeletal muscle mass are associated with higher bone mineral content in children. Nutr Metab (Lond) 2010; 7: 41. PMCID: 2886077.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 41
    • Dorsey, K.B.1    Thornton, J.C.2    Heymsfield, S.B.3    Gallagher, D.4
  • 12
    • 77951473692 scopus 로고    scopus 로고
    • Functional consequences of sarcopenia and dynapenia in the elderly
    • PMCID:2895460
    • Clark BC, Manini TM. Functional consequences of sarcopenia and dynapenia in the elderly. Curr Opin Clin Nutr Metab Care 2010; 13: 271-6. PMCID: 2895460.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 271-276
    • Clark, B.C.1    Manini, T.M.2
  • 14
    • 79955647519 scopus 로고    scopus 로고
    • Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy
    • Buford TW, Anton SD, Judge AR et al. Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev 2010; 9: 369-83.
    • (2010) Ageing Res Rev , vol.9 , pp. 369-383
    • Buford, T.W.1    Anton, S.D.2    Judge, A.R.3
  • 15
    • 0037341605 scopus 로고    scopus 로고
    • Sarcopenia - Consequences, mechanisms, and potential therapies
    • Greenlund LJ, Nair KS. Sarcopenia - consequences, mechanisms, and potential therapies. Mech Ageing Dev 2003; 124: 287-99.
    • (2003) Mech Ageing Dev , vol.124 , pp. 287-299
    • Greenlund, L.J.1    Nair, K.S.2
  • 16
    • 0032899114 scopus 로고    scopus 로고
    • The pathophysiology of wasting in the elderly
    • Roubenoff R. The pathophysiology of wasting in the elderly. J Nutr 1999; 129 (1S Suppl): 256S-9S.
    • (1999) J Nutr , vol.129 , Issue.1 SUPPL.
    • Roubenoff, R.1
  • 17
    • 78349301557 scopus 로고    scopus 로고
    • Recent advances in the biology and therapy of muscle wasting
    • Glass D, Roubenoff R. Recent advances in the biology and therapy of muscle wasting. Ann NY Acad Sci 2010; 1211: 25-36.
    • (2010) Ann NY Acad Sci , vol.1211 , pp. 25-36
    • Glass, D.1    Roubenoff, R.2
  • 18
    • 57349109417 scopus 로고    scopus 로고
    • Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading
    • PMCID:2612472
    • Siu PM, Pistilli EE, Alway SE. Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading. J Appl Physiol 2008; 105: 1695-705. PMCID: 2612472.
    • (2008) J Appl Physiol , vol.105 , pp. 1695-1705
    • Siu, P.M.1    Pistilli, E.E.2    Alway, S.E.3
  • 19
    • 34047213532 scopus 로고    scopus 로고
    • Oxidative stress, chronic disease, and muscle wasting
    • Moylan JS, Reid MB. Oxidative stress, chronic disease, and muscle wasting. Muscle Nerve 2007; 35: 411-29.
    • (2007) Muscle Nerve , vol.35 , pp. 411-429
    • Moylan, J.S.1    Reid, M.B.2
  • 20
    • 57949087452 scopus 로고    scopus 로고
    • Molecular inflammation: Underpinnings of aging and age-related diseases
    • Chung HY, Cesari M, Anton S et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009; 8: 18-30.
    • (2009) Ageing Res Rev , vol.8 , pp. 18-30
    • Chung, H.Y.1    Cesari, M.2    Anton, S.3
  • 21
    • 70350289385 scopus 로고    scopus 로고
    • Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle
    • Buford TW, Cooke MB, Willoughby DS. Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle. Eur J Appl Physiol 2009; 107: 463-71.
    • (2009) Eur J Appl Physiol , vol.107 , pp. 463-471
    • Buford, T.W.1    Cooke, M.B.2    Willoughby, D.S.3
  • 23
    • 33847767040 scopus 로고    scopus 로고
    • Sarcopenic obesity and inflammation in the InCHIANTI study
    • PMCID: 2645665
    • Schrager MA, Metter EJ, Simonsick E et al. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol 2007; 102: 919-25. PMCID: 2645665.
    • (2007) J Appl Physiol , vol.102 , pp. 919-925
    • Schrager, M.A.1    Metter, E.J.2    Simonsick, E.3
  • 24
    • 39649086079 scopus 로고    scopus 로고
    • Physical activity, inflammation, and muscle loss
    • Roubenoff R. Physical activity, inflammation, and muscle loss. Nutr Rev 2007; 65: S208-12.
    • (2007) Nutr Rev , vol.65
    • Roubenoff, R.1
  • 25
    • 0029563524 scopus 로고
    • Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65
    • Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum 1995; 38: 1762-70.
    • (1995) Arthritis Rheum , vol.38 , pp. 1762-1770
    • Handel, M.L.1    McMorrow, L.B.2    Gravallese, E.M.3
  • 26
    • 77951922812 scopus 로고    scopus 로고
    • Oxidative stress, molecular inflammation and sarcopenia
    • PMCID: 2871128
    • Meng SJ, Yu LJ. Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 2010; 11: 1509-26. PMCID: 2871128.
    • (2010) Int J Mol Sci , vol.11 , pp. 1509-1526
    • Meng, S.J.1    Yu, L.J.2
  • 27
    • 84884211315 scopus 로고    scopus 로고
    • Molecular Inflammation as an underlying mechanism of the aging process and age-related diseases
    • doi: 10.1177/0022034510387794. Epub 2011 Mar 29
    • Chung HY, Lee EK, Choi YJ et al. Molecular Inflammation as an underlying mechanism of the aging process and age-related diseases. J Dent Res 2011; 90: 830-40. doi: 10.1177/0022034510387794. Epub 2011 Mar 29.
    • (2011) J Dent Res , vol.90 , pp. 830-840
    • Chung, H.Y.1    Lee, E.K.2    Choi, Y.J.3
  • 28
    • 24744449943 scopus 로고    scopus 로고
    • IGF-1, inflammation and stem cells: Interactions during muscle regeneration
    • Mourkioti F, Rosenthal N. IGF-1, inflammation and stem cells: interactions during muscle regeneration. Trends Immunol 2005; 26: 535-42.
    • (2005) Trends Immunol , vol.26 , pp. 535-542
    • Mourkioti, F.1    Rosenthal, N.2
  • 29
    • 17444418617 scopus 로고    scopus 로고
    • Age-related differences in skeletal muscle protein synthesis: Relation to markers of immune activation
    • Toth MJ, Matthews DE, Tracy RP, Previs MJ. Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. Am J Physiol Endocrinol Metab 2005; 288: E883-91.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Toth, M.J.1    Matthews, D.E.2    Tracy, R.P.3    Previs, M.J.4
  • 30
    • 33746282410 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha signaling in skeletal muscle: Effects of age and caloric restriction
    • Dirks AJ, Leeuwenburgh C. Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction. J Nutr Biochem 2006; 17: 501-8.
    • (2006) J Nutr Biochem , vol.17 , pp. 501-508
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 31
    • 24044485930 scopus 로고    scopus 로고
    • Sarcopenia, obesity, and inflammation - Results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study
    • Cesari M, Kritchevsky SB, Baumgartner RN et al. Sarcopenia, obesity, and inflammation - results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr 2005; 82: 428-34.
    • (2005) Am J Clin Nutr , vol.82 , pp. 428-434
    • Cesari, M.1    Kritchevsky, S.B.2    Baumgartner, R.N.3
  • 32
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: A metabolic dialogue in the language of inflammation
    • Ferrante AW Jr. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007; 262: 408-14.
    • (2007) J Intern Med , vol.262 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 33
    • 79851509926 scopus 로고    scopus 로고
    • Sarcopenic obesity: Satellite cells in the aging muscle
    • Thornell LE. Sarcopenic obesity: satellite cells in the aging muscle. Curr Opin Clin Nutr Metab Care 2011; 14: 22-7.
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 22-27
    • Thornell, L.E.1
  • 35
    • 0029759443 scopus 로고    scopus 로고
    • Aging and oxidative stress: Modulation by dietary restriction
    • Yu BP. Aging and oxidative stress: modulation by dietary restriction. Free Radic Biol Med 1996; 21: 651-68.
    • (1996) Free Radic Biol Med , vol.21 , pp. 651-668
    • Yu, B.P.1
  • 36
    • 34548407055 scopus 로고    scopus 로고
    • Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde
    • Kim DH, Kim CH, Kim MS et al. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology 2007; 8: 545-54.
    • (2007) Biogerontology , vol.8 , pp. 545-554
    • Kim, D.H.1    Kim, C.H.2    Kim, M.S.3
  • 37
    • 0034102203 scopus 로고    scopus 로고
    • The effect of age on cyclooxygenase- 2 gene expression: NF-kappaB activation and IkappaBalpha degradation
    • Kim HJ, Kim KW, Yu BP, Chung HY. The effect of age on cyclooxygenase- 2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic Biol Med 2000; 28: 683-92.
    • (2000) Free Radic Biol Med , vol.28 , pp. 683-692
    • Kim, H.J.1    Kim, K.W.2    Yu, B.P.3    Chung, H.Y.4
  • 38
    • 34447332785 scopus 로고    scopus 로고
    • Down-regulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues
    • Kim HK, Park HR, Lee JS, Chung TS, Chung HY, Chung J. Down-regulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues. Biogerontology 2007; 8: 399-408.
    • (2007) Biogerontology , vol.8 , pp. 399-408
    • Kim, H.K.1    Park, H.R.2    Lee, J.S.3    Chung, T.S.4    Chung, H.Y.5    Chung, J.6
  • 40
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging. An evolutionary perspective on immunosenescence
    • Franceschi C, Bonafe M, Valensin S et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000; 908: 244-54.
    • (2000) Ann NY Acad Sci , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 41
    • 33750591642 scopus 로고    scopus 로고
    • Role for IKK2 in muscle: Waste not, want not
    • PMCID: 1626137
    • Karin M. Role for IKK2 in muscle: waste not, want not. J Clin Invest 2006; 116: 2866-8. PMCID: 1626137.
    • (2006) J Clin Invest , vol.116 , pp. 2866-2868
    • Karin, M.1
  • 42
    • 0032575379 scopus 로고    scopus 로고
    • Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: Discrimination between free and NFkappaB- bound substrate
    • Zandi E, Chen Y, Karin M. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NFkappaB- bound substrate. Science 1998; 281: 1360-3.
    • (1998) Science , vol.281 , pp. 1360-1363
    • Zandi, E.1    Chen, Y.2    Karin, M.3
  • 43
    • 14644400387 scopus 로고    scopus 로고
    • TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
    • PMCID: 3099533
    • Li YP, Chen Y, John J et al. TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. Faseb J 2005; 19: 362-70. PMCID: 3099533.
    • (2005) Faseb J , vol.19 , pp. 362-370
    • Li, Y.P.1    Chen, Y.2    John, J.3
  • 44
    • 0033696398 scopus 로고    scopus 로고
    • NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes
    • Li YP, Reid MB. NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol 2000; 279: R1165-70.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.279
    • Li, Y.P.1    Reid, M.B.2
  • 45
    • 13444271923 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress
    • Lee HC, Wei YH. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol 2005; 37: 822-34.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 822-834
    • Lee, H.C.1    Wei, Y.H.2
  • 46
    • 0030069213 scopus 로고    scopus 로고
    • Molecular basis of sun-induced premature skin ageing and retinoid antagonism
    • Fisher GJ, Datta SC, Talwar HS et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 1996; 379: 335-9.
    • (1996) Nature , vol.379 , pp. 335-339
    • Fisher, G.J.1    Datta, S.C.2    Talwar, H.S.3
  • 47
    • 79958072264 scopus 로고    scopus 로고
    • Activation of NFkappaB pathway in Duchenne muscular dystrophy: Relation to age
    • Messina S, Vita GL, Aguennouz M et al. Activation of NFkappaB pathway in Duchenne muscular dystrophy: relation to age. Acta Myol 2011; 30: 16-23.
    • (2011) Acta Myol , vol.30 , pp. 16-23
    • Messina, S.1    Vita, G.L.2    Aguennouz, M.3
  • 48
    • 0035722694 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and muscle wasting: A cellular perspective
    • PMCID: 59514
    • Reid MB, Li YP. Tumor necrosis factor-alpha and muscle wasting: a cellular perspective. Respir Res 2001; 2: 269-72. PMCID: 59514.
    • (2001) Respir Res , vol.2 , pp. 269-272
    • Reid, M.B.1    Li, Y.P.2
  • 49
    • 23944456384 scopus 로고    scopus 로고
    • Skeletal muscle hypertrophy and atrophy signaling pathways
    • Glass DJ. Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol 2005; 37: 1974-84.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1974-1984
    • Glass, D.J.1
  • 50
    • 0036845620 scopus 로고    scopus 로고
    • Patterns of gene expression in atrophying skeletal muscles: Response to food deprivation
    • Jagoe RT, Lecker SH, Gomes M, Goldberg AL. Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. Faseb J 2002; 16: 1697-712.
    • (2002) Faseb J , vol.16 , pp. 1697-1712
    • Jagoe, R.T.1    Lecker, S.H.2    Gomes, M.3    Goldberg, A.L.4
  • 51
    • 25144443718 scopus 로고    scopus 로고
    • The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture)
    • Hershko A. The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture). Angew Chem Int Ed Engl 2005; 44: 5932-43.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 5932-5943
    • Hershko, A.1
  • 52
    • 0035941020 scopus 로고    scopus 로고
    • Identification of ubiquitin ligases required for skeletal muscle atrophy
    • Bodine SC, Latres E, Baumhueter S et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001; 294: 1704-8.
    • (2001) Science , vol.294 , pp. 1704-1708
    • Bodine, S.C.1    Latres, E.2    Baumhueter, S.3
  • 53
    • 0037318822 scopus 로고    scopus 로고
    • Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
    • Glass DJ. Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat Cell Biol 2003; 5: 87-90.
    • (2003) Nat Cell Biol , vol.5 , pp. 87-90
    • Glass, D.J.1
  • 54
    • 0141791457 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes
    • Li YP, Chen Y, Li AS, Reid MB. Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes. Am J Physiol Cell Physiol 2003; 285: C806-12.
    • (2003) Am J Physiol Cell Physiol , vol.285
    • Li, Y.P.1    Chen, Y.2    Li, A.S.3    Reid, M.B.4
  • 55
    • 85047689951 scopus 로고    scopus 로고
    • Ubiquitin-protein ligases in muscle wasting: Multiple parallel pathways?
    • Lecker SH. Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways? Curr Opin Clin Nutr Metab Care 2003; 6: 271-5.
    • (2003) Curr Opin Clin Nutr Metab Care , vol.6 , pp. 271-275
    • Lecker, S.H.1
  • 56
    • 0032947267 scopus 로고    scopus 로고
    • Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states
    • Lecker SH, Solomon V, Mitch WE, Goldberg AL. Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr 1999; 129 (1S Suppl): 227S-37S.
    • (1999) J Nutr , vol.129 , Issue.1 SUPPL.
    • Lecker, S.H.1    Solomon, V.2    Mitch, W.E.3    Goldberg, A.L.4
  • 57
    • 33748526240 scopus 로고    scopus 로고
    • Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are upregulated in aged rat Tibialis Anterior muscle
    • Clavel S, Coldefy AS, Kurkdjian E, Salles J, Margaritis I, Derijard B. Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are upregulated in aged rat Tibialis Anterior muscle. Mech Ageing Dev 2006; 127: 794-801.
    • (2006) Mech Ageing Dev , vol.127 , pp. 794-801
    • Clavel, S.1    Coldefy, A.S.2    Kurkdjian, E.3    Salles, J.4    Margaritis, I.5    Derijard, B.6
  • 58
    • 78751535748 scopus 로고    scopus 로고
    • Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model
    • Sishi B, Loos B, Ellis B, Smith W, du Toit EF, Engelbrecht AM. Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp Physiol 2011; 96: 179-93.
    • (2011) Exp Physiol , vol.96 , pp. 179-193
    • Sishi, B.1    Loos, B.2    Ellis, B.3    Smith, W.4    Du Toit, E.F.5    Engelbrecht, A.M.6
  • 59
    • 5444262078 scopus 로고    scopus 로고
    • IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    • Cai D, Frantz JD, Tawa NE Jr et al. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 2004; 119: 285-98.
    • (2004) Cell , vol.119 , pp. 285-298
    • Cai, D.1    Frantz, J.D.2    Tawa Jr., N.E.3
  • 60
    • 14944352786 scopus 로고    scopus 로고
    • NF-kappaB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitinproteasome system in skeletal muscle
    • PMCID: 2361865
    • Wyke SM, Tisdale MJ. NF-kappaB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitinproteasome system in skeletal muscle. Br J Cancer 2005; 92: 711-21. PMCID: 2361865.
    • (2005) Br J Cancer , vol.92 , pp. 711-721
    • Wyke, S.M.1    Tisdale, M.J.2
  • 61
    • 79951581392 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase alpha (IKKalpha) or IKKbeta (IKKbeta) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy
    • PMCID: 3056397
    • Reed SA, Senf SM, Cornwell EW, Kandarian SC, Judge AR. Inhibition of IkappaB kinase alpha (IKKalpha) or IKKbeta (IKKbeta) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun 2011; 405: 491-6. PMCID: 3056397.
    • (2011) Biochem Biophys Res Commun , vol.405 , pp. 491-496
    • Reed, S.A.1    Senf, S.M.2    Cornwell, E.W.3    Kandarian, S.C.4    Judge, A.R.5
  • 62
    • 0031802331 scopus 로고    scopus 로고
    • Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha
    • Li YP, Schwartz RJ, Waddell ID, Holloway BR, Reid MB. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. Faseb J 1998; 12: 871-80.
    • (1998) Faseb J , vol.12 , pp. 871-880
    • Li, Y.P.1    Schwartz, R.J.2    Waddell, I.D.3    Holloway, B.R.4    Reid, M.B.5
  • 63
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud J, Gupta S, Rogers JS et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995; 270: 7420-6.
    • (1995) J Biol Chem , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3
  • 64
    • 56449095862 scopus 로고    scopus 로고
    • The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy
    • Murton AJ, Constantin D, Greenhaff PL. The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy. Biochim Biophys Acta 2008; 1782: 730-43.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 730-743
    • Murton, A.J.1    Constantin, D.2    Greenhaff, P.L.3
  • 65
    • 33746611524 scopus 로고    scopus 로고
    • Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle
    • Edstrom E, Altun M, Hagglund M, Ulfhake B. Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. J Gerontol A Biol Sci Med Sci 2006; 61: 663-74.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 663-674
    • Edstrom, E.1    Altun, M.2    Hagglund, M.3    Ulfhake, B.4
  • 66
    • 25644432770 scopus 로고    scopus 로고
    • Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age
    • Whitman SA, Wacker MJ, Richmond SR, Godard MP. Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age. Pflugers Arch 2005; 450: 437-46.
    • (2005) Pflugers Arch , vol.450 , pp. 437-446
    • Whitman, S.A.1    Wacker, M.J.2    Richmond, S.R.3    Godard, M.P.4
  • 67
    • 0034918907 scopus 로고    scopus 로고
    • Myogenic satellite cells: Physiology to molecular biology
    • Hawke TJ, Garry DJ. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol 2001; 91: 534-51.
    • (2001) J Appl Physiol , vol.91 , pp. 534-551
    • Hawke, T.J.1    Garry, D.J.2
  • 68
    • 69049092616 scopus 로고    scopus 로고
    • The impact of sarcopenia and exercise training on skeletal muscle satellite cells
    • Snijders T, Verdijk LB, van Loon LJ. The impact of sarcopenia and exercise training on skeletal muscle satellite cells. Ageing Res Rev 2009; 8: 328-38.
    • (2009) Ageing Res Rev , vol.8 , pp. 328-338
    • Snijders, T.1    Verdijk, L.B.2    Van Loon, L.J.3
  • 69
    • 17744374520 scopus 로고    scopus 로고
    • Muscle stem cells and exercise training
    • Hawke TJ. Muscle stem cells and exercise training. Exerc Sport Sci Rev 2005; 33: 63-8.
    • (2005) Exerc Sport Sci Rev , vol.33 , pp. 63-68
    • Hawke, T.J.1
  • 70
    • 33751175205 scopus 로고    scopus 로고
    • Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women
    • Petrella JK, Kim JS, Cross JM, Kosek DJ, Bamman MM. Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women. Am J Physiol Endocrinol Metab 2006; 291: E937-46.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Petrella, J.K.1    Kim, J.S.2    Cross, J.M.3    Kosek, D.J.4    Bamman, M.M.5
  • 71
    • 0347361625 scopus 로고    scopus 로고
    • Satellite cells and myonuclei in young and elderly women and men
    • Kadi F, Charifi N, Denis C, Lexell J. Satellite cells and myonuclei in young and elderly women and men. Muscle Nerve 2004; 29: 120-7.
    • (2004) Muscle Nerve , vol.29 , pp. 120-127
    • Kadi, F.1    Charifi, N.2    Denis, C.3    Lexell, J.4
  • 73
    • 24044487885 scopus 로고    scopus 로고
    • In vivo physiological cross-sectional area and specific force are reduced in the gastrocnemius of elderly men
    • Morse CI, Thom JM, Reeves ND, Birch KM, Narici MV. In vivo physiological cross-sectional area and specific force are reduced in the gastrocnemius of elderly men. J Appl Physiol 2005; 99: 1050-5.
    • (2005) J Appl Physiol , vol.99 , pp. 1050-1055
    • Morse, C.I.1    Thom, J.M.2    Reeves, N.D.3    Birch, K.M.4    Narici, M.V.5
  • 74
    • 34347400686 scopus 로고    scopus 로고
    • Gastrocnemius specific force is increased in elderly males following a 12-month physical training programme
    • Morse CI, Thom JM, Mian OS, Birch KM, Narici MV. Gastrocnemius specific force is increased in elderly males following a 12-month physical training programme. Eur J Appl Physiol 2007; 100: 563-70.
    • (2007) Eur J Appl Physiol , vol.100 , pp. 563-570
    • Morse, C.I.1    Thom, J.M.2    Mian, O.S.3    Birch, K.M.4    Narici, M.V.5
  • 75
    • 64849110613 scopus 로고    scopus 로고
    • Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men
    • PMCID: 2655000
    • Verdijk LB, Gleeson BG, Jonkers RA et al. Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men. J Gerontol A Biol Sci Med Sci 2009; 64: 332-9. PMCID: 2655000.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 332-339
    • Verdijk, L.B.1    Gleeson, B.G.2    Jonkers, R.A.3
  • 76
    • 28044432532 scopus 로고    scopus 로고
    • Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women
    • Kim JS, Kosek DJ, Petrella JK, Cross JM, Bamman MM. Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women. J Appl Physiol 2005; 99: 2149-58.
    • (2005) J Appl Physiol , vol.99 , pp. 2149-2158
    • Kim, J.S.1    Kosek, D.J.2    Petrella, J.K.3    Cross, J.M.4    Bamman, M.M.5
  • 77
    • 36949040620 scopus 로고    scopus 로고
    • Age-related skeletal muscle dysfunction: Causes and mechanisms
    • Degens H. Age-related skeletal muscle dysfunction: causes and mechanisms. J Musculoskelet Neuronal Interact 2007; 7: 246-52.
    • (2007) J Musculoskelet Neuronal Interact , vol.7 , pp. 246-252
    • Degens, H.1
  • 79
    • 33646362086 scopus 로고    scopus 로고
    • Recovery from contraction-induced injury is impaired in weight-bearing muscles of old male mice
    • Rader EP, Faulkner JA. Recovery from contraction-induced injury is impaired in weight-bearing muscles of old male mice. J Appl Physiol 2006; 100: 656-61.
    • (2006) J Appl Physiol , vol.100 , pp. 656-661
    • Rader, E.P.1    Faulkner, J.A.2
  • 80
    • 33748455501 scopus 로고    scopus 로고
    • Effect of aging on the recovery following contraction-induced injury in muscles of female mice
    • Rader EP, Faulkner JA. Effect of aging on the recovery following contraction-induced injury in muscles of female mice. J Appl Physiol 2006; 101: 887-92.
    • (2006) J Appl Physiol , vol.101 , pp. 887-892
    • Rader, E.P.1    Faulkner, J.A.2
  • 81
    • 0024392416 scopus 로고
    • Muscle transplantation between young and old rats: Age of host determines recovery
    • Carlson BM, Faulkner JA. Muscle transplantation between young and old rats: age of host determines recovery. Am J Physiol 1989; 256: C1262-6.
    • (1989) Am J Physiol , vol.256
    • Carlson, B.M.1    Faulkner, J.A.2
  • 82
    • 75649146988 scopus 로고    scopus 로고
    • The role of systemic inflammation in age-related muscle weakness and wasting
    • Degens H. The role of systemic inflammation in age-related muscle weakness and wasting. Scand J Med Sci Sports 2010; 20: 28-38.
    • (2010) Scand J Med Sci Sports , vol.20 , pp. 28-38
    • Degens, H.1
  • 85
    • 34250669605 scopus 로고    scopus 로고
    • TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK
    • PMCID: 3099536
    • Chen SE, Jin B, Li YP. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 2007; 292: C1660-71. PMCID: 3099536.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Chen, S.E.1    Jin, B.2    Li, Y.P.3
  • 87
    • 0034730251 scopus 로고    scopus 로고
    • NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia
    • Guttridge DC, Mayo MW, Madrid LV, Wang CY, Baldwin AS Jr. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 2000; 289: 2363-6.
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3    Wang, C.Y.4    Baldwin Jr., A.S.5
  • 88
    • 0035020963 scopus 로고    scopus 로고
    • Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB
    • Langen RC, Schols AM, Kelders MC, Wouters EF, Janssen- Heininger YM. Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. Faseb J 2001; 15: 1169-80.
    • (2001) Faseb J , vol.15 , pp. 1169-1180
    • Langen, R.C.1    Schols, A.M.2    Kelders, M.C.3    Wouters, E.F.4    Janssen- Heininger, Y.M.5
  • 89
    • 0033952368 scopus 로고    scopus 로고
    • The molecular regulation of myogenesis
    • Sabourin LA, Rudnicki MA. The molecular regulation of myogenesis. Clin Genet 2000; 57: 16-25.
    • (2000) Clin Genet , vol.57 , pp. 16-25
    • Sabourin, L.A.1    Rudnicki, M.A.2
  • 90
    • 22344444732 scopus 로고    scopus 로고
    • The role of apoptosis in age-related skeletal muscle atrophy
    • Dirks AJ, Leeuwenburgh C. The role of apoptosis in age-related skeletal muscle atrophy. Sports Med 2005; 35: 473-83.
    • (2005) Sports Med , vol.35 , pp. 473-483
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 92
    • 41149139501 scopus 로고    scopus 로고
    • Nuclear apoptosis contributes to sarcopenia
    • PMCID: 2778230
    • Alway SE, Siu PM. Nuclear apoptosis contributes to sarcopenia. Exerc Sport Sci Rev 2008; 36: 51-7. PMCID: 2778230.
    • (2008) Exerc Sport Sci Rev , vol.36 , pp. 51-57
    • Alway, S.E.1    Siu, P.M.2
  • 93
    • 0347318125 scopus 로고    scopus 로고
    • Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase- 3, and caspase-12
    • Dirks AJ, Leeuwenburgh C. Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase- 3, and caspase-12. Free Radic Biol Med 2004; 36: 27-39.
    • (2004) Free Radic Biol Med , vol.36 , pp. 27-39
    • Dirks, A.J.1    Leeuwenburgh, C.2
  • 94
    • 0036088709 scopus 로고    scopus 로고
    • Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats
    • Alway SE, Degens H, Krishnamurthy G, Smith CA. Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats. Am J Physiol Cell Physiol 2002; 283: C66-76.
    • (2002) Am J Physiol Cell Physiol , vol.283
    • Alway, S.E.1    Degens, H.2    Krishnamurthy, G.3    Smith, C.A.4
  • 95
    • 33845373054 scopus 로고    scopus 로고
    • Death receptor-associated pro-apoptotic signaling in aged skeletal muscle
    • Pistilli EE, Jackson JR, Alway SE. Death receptor-associated pro-apoptotic signaling in aged skeletal muscle. Apoptosis 2006; 11: 2115-26.
    • (2006) Apoptosis , vol.11 , pp. 2115-2126
    • Pistilli, E.E.1    Jackson, J.R.2    Alway, S.E.3
  • 96
    • 16344385647 scopus 로고    scopus 로고
    • Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction
    • Phillips T, Leeuwenburgh C. Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. Faseb J 2005; 19: 668-70.
    • (2005) Faseb J , vol.19 , pp. 668-670
    • Phillips, T.1    Leeuwenburgh, C.2
  • 98
    • 1642422773 scopus 로고    scopus 로고
    • Mitochondrial free radical production and cell signaling
    • Cadenas E. Mitochondrial free radical production and cell signaling. Mol Aspects Med 2004; 25: 17-26.
    • (2004) Mol Aspects Med , vol.25 , pp. 17-26
    • Cadenas, E.1
  • 99
    • 0032032941 scopus 로고    scopus 로고
    • Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats
    • Nitahara JA, Cheng W, Liu Y et al. Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats. J Mol Cell Cardiol 1998; 30: 519-35.
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 519-535
    • Nitahara, J.A.1    Cheng, W.2    Liu, Y.3
  • 100
    • 0034185616 scopus 로고    scopus 로고
    • Protein oxidation and age-dependent alterations in calcium homeostasis
    • Squier TC, Bigelow DJ. Protein oxidation and age-dependent alterations in calcium homeostasis. Front Biosci 2000; 5: D504-26.
    • (2000) Front Biosci , vol.5
    • Squier, T.C.1    Bigelow, D.J.2
  • 101
    • 12144284036 scopus 로고    scopus 로고
    • Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading
    • Siu PM, Pistilli EE, Butler DC, Alway SE. Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading. Am J Physiol Cell Physiol 2005; 288: C338-49.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Siu, P.M.1    Pistilli, E.E.2    Butler, D.C.3    Alway, S.E.4
  • 102
    • 46649114727 scopus 로고    scopus 로고
    • Age-related activation of mitochondrial caspaseindependent apoptotic signaling in rat gastrocnemius muscle
    • PMCID: 2585824
    • Marzetti E, Wohlgemuth SE, Lees HA, Chung HY, Giovannini S, Leeuwenburgh C. Age-related activation of mitochondrial caspaseindependent apoptotic signaling in rat gastrocnemius muscle. Mech Ageing Dev 2008; 129: 542-9. PMCID: 2585824.
    • (2008) Mech Ageing Dev , vol.129 , pp. 542-549
    • Marzetti, E.1    Wohlgemuth, S.E.2    Lees, H.A.3    Chung, H.Y.4    Giovannini, S.5    Leeuwenburgh, C.6
  • 103
    • 0033582526 scopus 로고    scopus 로고
    • Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
    • Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 1999; 274: 5053-60.
    • (1999) J Biol Chem , vol.274 , pp. 5053-5060
    • Sun, X.M.1    MacFarlane, M.2    Zhuang, J.3    Wolf, B.B.4    Green, D.R.5    Cohen, G.M.6
  • 104
    • 0034096242 scopus 로고    scopus 로고
    • Body composition in healthy aging
    • Baumgartner RN. Body composition in healthy aging. Ann NY Acad Sci 2000; 904: 437-48.
    • (2000) Ann NY Acad Sci , vol.904 , pp. 437-448
    • Baumgartner, R.N.1
  • 105
    • 4644328086 scopus 로고    scopus 로고
    • Sarcopenic obesity: The confluence of two epidemics
    • Roubenoff R. Sarcopenic obesity: the confluence of two epidemics. Obes Res 2004; 12: 887-8.
    • (2004) Obes Res , vol.12 , pp. 887-888
    • Roubenoff, R.1
  • 107
    • 2442600121 scopus 로고    scopus 로고
    • Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women
    • Song MY, Ruts E, Kim J, Janumala I, Heymsfield S, Gallagher D. Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women. Am J Clin Nutr 2004; 79: 874-80.
    • (2004) Am J Clin Nutr , vol.79 , pp. 874-880
    • Song, M.Y.1    Ruts, E.2    Kim, J.3    Janumala, I.4    Heymsfield, S.5    Gallagher, D.6
  • 108
    • 4043159763 scopus 로고    scopus 로고
    • Intramuscular and liver triglycerides are increased in the elderly
    • Cree MG, Newcomer BR, Katsanos CS et al. Intramuscular and liver triglycerides are increased in the elderly. J Clin Endocrinol Metab 2004; 89: 3864-71.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3864-3871
    • Cree, M.G.1    Newcomer, B.R.2    Katsanos, C.S.3
  • 109
    • 24044485930 scopus 로고    scopus 로고
    • Sarcopenia, obesity, and inflammation - Results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study
    • Cesari M, Kritchevsky SB, Baumgartner RN et al. Sarcopenia, obesity, and inflammation - results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr 2005; 82: 428-34.
    • (2005) Am J Clin Nutr , vol.82 , pp. 428-434
    • Cesari, M.1    Kritchevsky, S.B.2    Baumgartner, R.N.3
  • 110
    • 54249117707 scopus 로고    scopus 로고
    • Inflammation: Roles in aging and sarcopenia
    • Jensen GL. Inflammation: roles in aging and sarcopenia. JPEN J Parenter Enteral Nutr 2008; 32: 656-9.
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , pp. 656-659
    • Jensen, G.L.1
  • 111
    • 30844439165 scopus 로고    scopus 로고
    • Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects
    • Yende S, Waterer GW, Tolley EA et al. Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax 2006; 61: 10-6.
    • (2006) Thorax , vol.61 , pp. 10-16
    • Yende, S.1    Waterer, G.W.2    Tolley, E.A.3
  • 112
    • 84855854953 scopus 로고    scopus 로고
    • Osteoporosis and inflammation
    • Mundy GR. Osteoporosis and inflammation. Nutr Rev 2007; 65: 147-51.
    • (2007) Nutr Rev , vol.65 , pp. 147-151
    • Mundy, G.R.1
  • 113
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (New York) 1993; 259: 87-91.
    • (1993) Science (New York) , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 114
    • 33845209693 scopus 로고    scopus 로고
    • Skeletal muscle apoptosis, sarcopenia and frailty at old age
    • Marzetti E, Leeuwenburgh C. Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol 2006; 41: 1234-8.
    • (2006) Exp Gerontol , vol.41 , pp. 1234-1238
    • Marzetti, E.1    Leeuwenburgh, C.2
  • 115
    • 4644328086 scopus 로고    scopus 로고
    • Sarcopenic obesity: The confluence of two epidemics
    • Roubenoff R. Sarcopenic obesity: the confluence of two epidemics. Obes Res 2004; 12: 887-8.
    • (2004) Obes Res , vol.12 , pp. 887-888
    • Roubenoff, R.1
  • 116
    • 80051586848 scopus 로고    scopus 로고
    • Adiposity attenuates muscle quality and the adaptive response to resistance exercise in non-obese, healthy adults
    • doi: 10.1038/ijo.2010.257. Epub 2010 Dec 7
    • Peterson MD, Liu D, Gordish-Dressman H et al. Adiposity attenuates muscle quality and the adaptive response to resistance exercise in non-obese, healthy adults. Int J Obes (Lond) 2011; 35: 1095-103. doi: 10.1038/ijo.2010.257. Epub 2010 Dec 7.
    • (2011) Int J Obes (Lond) , vol.35 , pp. 1095-1103
    • Peterson, M.D.1    Liu, D.2    Gordish-Dressman, H.3
  • 118
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007; 56: 1010-3.
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 119
    • 31044447347 scopus 로고    scopus 로고
    • Inflamed fat: What starts the fire?
    • PMCID: 1323268
    • Neels JG, Olefsky JM. Inflamed fat: what starts the fire? J Clin Invest 2006; 116: 33-5. PMCID: 1323268.
    • (2006) J Clin Invest , vol.116 , pp. 33-35
    • Neels, J.G.1    Olefsky, J.M.2
  • 120
    • 23944444300 scopus 로고    scopus 로고
    • Health consequences of obesity in the elderly: A review of four unresolved questions
    • Zamboni M, Mazzali G, Zoico E et al. Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond) 2005; 29: 1011-29.
    • (2005) Int J Obes (Lond) , vol.29 , pp. 1011-1029
    • Zamboni, M.1    Mazzali, G.2    Zoico, E.3
  • 121
    • 77956824021 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor beta/delta on the inflammatory basis of metabolic disease
    • PMCID: 2913795
    • Coll T, Barroso E, Alvarez-Guardia D et al. The role of peroxisome proliferator-activated receptor beta/delta on the inflammatory basis of metabolic disease. PPAR Res 2010; 2010. PMCID: 2913795.
    • (2010) PPAR Res 2010
    • Coll, T.1    Barroso, E.2    Alvarez-Guardia, D.3
  • 122
    • 77950202392 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells
    • Coll T, Alvarez-Guardia D, Barroso E et al. Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. Endocrinology 2010; 151: 1560-9.
    • (2010) Endocrinology , vol.151 , pp. 1560-1569
    • Coll, T.1    Alvarez-Guardia, D.2    Barroso, E.3
  • 123
    • 0346250165 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance: Potential links with inflammation
    • Perseghin G, Petersen K, Shulman GI. Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord 2003; 27 (Suppl 3): S6-11.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.SUPPL. 3
    • Perseghin, G.1    Petersen, K.2    Shulman, G.I.3
  • 124
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996; 27: 665-8.
    • (1996) Science , vol.27 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.