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Volumn 27, Issue 2, 2012, Pages 46-52

The Reciprocal Relationship Between Inflammation and Coagulation

Author keywords

Cytokines; Endothelium; Hemostasis; Immune; Sepsis; Toll like receptor

Indexed keywords

ANTITHROMBIN; CYTOKINE; PLASMIN; PROTEINASE ACTIVATED RECEPTOR; THROMBIN;

EID: 84866989789     PISSN: 19389736     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.tcam.2012.06.003     Document Type: Review
Times cited : (78)

References (110)
  • 1
    • 0036167107 scopus 로고    scopus 로고
    • Drosophila innate immunity: an evolutionary perspective
    • Hoffmann J.A., Reichhart J.M. Drosophila innate immunity: an evolutionary perspective. Nat Immunol 2002, 3:121-126.
    • (2002) Nat Immunol , vol.3 , pp. 121-126
    • Hoffmann, J.A.1    Reichhart, J.M.2
  • 2
    • 2342420998 scopus 로고    scopus 로고
    • The nexus between systemic inflammation and disordered coagulation in sepsis
    • Opal S.M. The nexus between systemic inflammation and disordered coagulation in sepsis. J Endotoxin Res 2004, 10:125-129.
    • (2004) J Endotoxin Res , vol.10 , pp. 125-129
    • Opal, S.M.1
  • 4
    • 0030843156 scopus 로고    scopus 로고
    • Sepsis: a new hypothesis for pathogenesis of the disease process
    • Bone R.C., Grodzin C.J., Balk R.A. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997, 112:235-243.
    • (1997) Chest , vol.112 , pp. 235-243
    • Bone, R.C.1    Grodzin, C.J.2    Balk, R.A.3
  • 5
  • 6
    • 11144310604 scopus 로고    scopus 로고
    • The search for a unified theory of coagulation and inflammation
    • Veldman A., Fischer D. The search for a unified theory of coagulation and inflammation. Cell Mol Life Sci 2004, 61:2744-2749.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 2744-2749
    • Veldman, A.1    Fischer, D.2
  • 7
    • 80054075823 scopus 로고    scopus 로고
    • Immunologic alterations and the pathogenesis of organ failure in the ICU
    • Opal S.M. Immunologic alterations and the pathogenesis of organ failure in the ICU. Semin Respir Crit Care Med 2011, 32:569-580.
    • (2011) Semin Respir Crit Care Med , vol.32 , pp. 569-580
    • Opal, S.M.1
  • 8
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 9
    • 36448943634 scopus 로고    scopus 로고
    • Sepsis in veterinary patients: what do we know and where can we go?
    • Otto C.M. Sepsis in veterinary patients: what do we know and where can we go?. J Vet Emerg Crit Care 2007, 17:329-332.
    • (2007) J Vet Emerg Crit Care , vol.17 , pp. 329-332
    • Otto, C.M.1
  • 10
    • 34247623265 scopus 로고    scopus 로고
    • Coagulation abnormalities in critically ill patients
    • Levi M., Opal S.M. Coagulation abnormalities in critically ill patients. Crit Care 2006, 10:222.
    • (2006) Crit Care , vol.10 , pp. 222
    • Levi, M.1    Opal, S.M.2
  • 11
    • 0036348390 scopus 로고    scopus 로고
    • Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome
    • Strauss R., Wehler M., Mehler K., Kreutzer D., Koebnick C., Hahn E.G. Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 2002, 30:1765-1771.
    • (2002) Crit Care Med , vol.30 , pp. 1765-1771
    • Strauss, R.1    Wehler, M.2    Mehler, K.3    Kreutzer, D.4    Koebnick, C.5    Hahn, E.G.6
  • 12
    • 0036348505 scopus 로고    scopus 로고
    • Thrombocytopenia and intensive care unit outcome: a sticky issue
    • Parker R.I. Thrombocytopenia and intensive care unit outcome: a sticky issue. Crit Care Med 2002, 30:1917-1918.
    • (2002) Crit Care Med , vol.30 , pp. 1917-1918
    • Parker, R.I.1
  • 13
    • 84926098364 scopus 로고    scopus 로고
    • Pro-inflammatory mechanisms in sepsis
    • Chong D.L., Sriskandan S. Pro-inflammatory mechanisms in sepsis. Contrib Microbiol 2011, 17:86-107.
    • (2011) Contrib Microbiol , vol.17 , pp. 86-107
    • Chong, D.L.1    Sriskandan, S.2
  • 14
    • 1542345501 scopus 로고    scopus 로고
    • Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function
    • Müller S., Ronfani L., Bianchi M.E. Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function. J Intern Med 2004, 255:332-343.
    • (2004) J Intern Med , vol.255 , pp. 332-343
    • Müller, S.1    Ronfani, L.2    Bianchi, M.E.3
  • 15
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: all we need to know about danger
    • Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007, 81:1-5.
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 16
    • 0035936836 scopus 로고    scopus 로고
    • Induction of direct antimicrobial activity through mammalian toll-like receptors
    • Thoma-Uszynski S., Stenger S., Takeuchi O., et al. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001, 291:1544-1547.
    • (2001) Science , vol.291 , pp. 1544-1547
    • Thoma-Uszynski, S.1    Stenger, S.2    Takeuchi, O.3
  • 17
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H., Kawai T., Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol 2011, 30:16-34.
    • (2011) Int Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 18
    • 33749152085 scopus 로고    scopus 로고
    • Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    • Doyle S.L., O'Neill L.A. Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 2006, 72:1102-1113.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1102-1113
    • Doyle, S.L.1    O'Neill, L.A.2
  • 19
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 20
    • 19944429804 scopus 로고    scopus 로고
    • Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis
    • Tsujimoto H., Ono S., Majima T., et al. Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 2005, 23:39-44.
    • (2005) Shock , vol.23 , pp. 39-44
    • Tsujimoto, H.1    Ono, S.2    Majima, T.3
  • 21
    • 0036255897 scopus 로고    scopus 로고
    • Endothelium: interface between coagulation and inflammation
    • Levi M., ten Cate H., van der Poll T. Endothelium: interface between coagulation and inflammation. Crit Care Med 2002, 30:S220-S224.
    • (2002) Crit Care Med , vol.30
    • Levi, M.1    ten Cate, H.2    van der Poll, T.3
  • 22
    • 36249020418 scopus 로고    scopus 로고
    • "Role reversal" for the receptor PAR1 in sepsis-induced vascular damage
    • Kaneider N.C., Leger A.J., Agarwal A., et al."Role reversal" for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol 2007, 8:1303-1312.
    • (2007) Nat Immunol , vol.8 , pp. 1303-1312
    • Kaneider, N.C.1    Leger, A.J.2    Agarwal, A.3
  • 23
    • 0034115161 scopus 로고    scopus 로고
    • Clinical implications of dysregulated cytokine production
    • Slifka M.K., Whitton J.L. Clinical implications of dysregulated cytokine production. J Mol Med (Berl) 2000, 78:74-80.
    • (2000) J Mol Med (Berl) , vol.78 , pp. 74-80
    • Slifka, M.K.1    Whitton, J.L.2
  • 24
    • 0033874108 scopus 로고    scopus 로고
    • Proinflammatory cytokines
    • Dinarello C.A. Proinflammatory cytokines. Chest 2000, 118:503-508.
    • (2000) Chest , vol.118 , pp. 503-508
    • Dinarello, C.A.1
  • 25
    • 0028293492 scopus 로고
    • Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors
    • Kirchhofer D., Tschopp T.B., Hadváry P., Baumgartner H.R. Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors. J Clin Invest 1994, 93:2073-2083.
    • (1994) J Clin Invest , vol.93 , pp. 2073-2083
    • Kirchhofer, D.1    Tschopp, T.B.2    Hadváry, P.3    Baumgartner, H.R.4
  • 26
    • 0034917278 scopus 로고    scopus 로고
    • Tissue factor: an enzyme cofactor and a true receptor
    • Morrissey J.H. Tissue factor: an enzyme cofactor and a true receptor. Thromb Haemost 2001, 86:66-74.
    • (2001) Thromb Haemost , vol.86 , pp. 66-74
    • Morrissey, J.H.1
  • 27
    • 0023851758 scopus 로고
    • Tissue factor and hemostasis
    • Nemerson Y. Tissue factor and hemostasis. Blood 1988, 71:1-8.
    • (1988) Blood , vol.71 , pp. 1-8
    • Nemerson, Y.1
  • 28
    • 0027402655 scopus 로고
    • Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation
    • Morrissey J.H., Macik B.G., Neuenschwander P.F., Comp P.C. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993, 81:734-744.
    • (1993) Blood , vol.81 , pp. 734-744
    • Morrissey, J.H.1    Macik, B.G.2    Neuenschwander, P.F.3    Comp, P.C.4
  • 29
    • 0028151281 scopus 로고
    • Platelet procoagulant complex assembly in a tissue factor-initiated system
    • Monroe D.M., Roberts H.R., Hoffman M. Platelet procoagulant complex assembly in a tissue factor-initiated system. Br J Haematol 1994, 88:364-371.
    • (1994) Br J Haematol , vol.88 , pp. 364-371
    • Monroe, D.M.1    Roberts, H.R.2    Hoffman, M.3
  • 30
    • 0020554745 scopus 로고
    • Cultured human endothelial cells generate tissue factor in response to endotoxin
    • Colucci M., Balconi G., Lorenzet R., et al. Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest 1983, 71:1893-1896.
    • (1983) J Clin Invest , vol.71 , pp. 1893-1896
    • Colucci, M.1    Balconi, G.2    Lorenzet, R.3
  • 31
    • 0021085112 scopus 로고
    • Direct induction of tissue factor synthesis by endotoxin in human macrophages from diverse anatomical sites
    • Semeraro N., Biondi A., Lorenzet R., Locati D., Mantovani A., Donati M.B. Direct induction of tissue factor synthesis by endotoxin in human macrophages from diverse anatomical sites. Immunology 1983, 50:529-535.
    • (1983) Immunology , vol.50 , pp. 529-535
    • Semeraro, N.1    Biondi, A.2    Lorenzet, R.3    Locati, D.4    Mantovani, A.5    Donati, M.B.6
  • 32
    • 0017345271 scopus 로고
    • Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes
    • Rothberger H., Zimmerman T.S., Spiegelberg H.L., Vaughan J.H. Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes. J Clin Invest 1977, 59:549-557.
    • (1977) J Clin Invest , vol.59 , pp. 549-557
    • Rothberger, H.1    Zimmerman, T.S.2    Spiegelberg, H.L.3    Vaughan, J.H.4
  • 33
    • 0023694658 scopus 로고
    • Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes
    • Conkling P.R., Greenberg C.S., Weinberg J.B. Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes. Blood 1988, 72:128-133.
    • (1988) Blood , vol.72 , pp. 128-133
    • Conkling, P.R.1    Greenberg, C.S.2    Weinberg, J.B.3
  • 34
    • 0010460867 scopus 로고
    • Inducible endothelial functions in inflammation and coagulation
    • Bevilacqua M.P., Gimbrone M.A. Inducible endothelial functions in inflammation and coagulation. Semin Thromb Hemost 1987, 13:425-433.
    • (1987) Semin Thromb Hemost , vol.13 , pp. 425-433
    • Bevilacqua, M.P.1    Gimbrone, M.A.2
  • 35
    • 0021199320 scopus 로고
    • Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells
    • Bevilacqua M.P., Pober J.S., Majeau G.R., Cotran R.S., Gimbrone M.A. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 1984, 160:618-623.
    • (1984) J Exp Med , vol.160 , pp. 618-623
    • Bevilacqua, M.P.1    Pober, J.S.2    Majeau, G.R.3    Cotran, R.S.4    Gimbrone, M.A.5
  • 36
    • 0016312084 scopus 로고
    • The stimulatory effect of platelets and platelet membranes on the procoagulant activity of leukocytes
    • Niemetz J., Marcus A.J. The stimulatory effect of platelets and platelet membranes on the procoagulant activity of leukocytes. J Clin Invest 1974, 54:1437-1443.
    • (1974) J Clin Invest , vol.54 , pp. 1437-1443
    • Niemetz, J.1    Marcus, A.J.2
  • 37
    • 0021795610 scopus 로고
    • In vitro stimulation of monocyte tissue factor activity by autologous platelets
    • Pinder P.B., Hunt J.A., Zacharski L.R. In vitro stimulation of monocyte tissue factor activity by autologous platelets. Am J Hematol 1985, 19:317-325.
    • (1985) Am J Hematol , vol.19 , pp. 317-325
    • Pinder, P.B.1    Hunt, J.A.2    Zacharski, L.R.3
  • 38
    • 21844455249 scopus 로고    scopus 로고
    • Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines
    • Szotowski B., Antoniak S., Poller W., Schultheiss H.P., Rauch U. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines. Circ Res 2005, 96:1233-1239.
    • (2005) Circ Res , vol.96 , pp. 1233-1239
    • Szotowski, B.1    Antoniak, S.2    Poller, W.3    Schultheiss, H.P.4    Rauch, U.5
  • 39
    • 0034808267 scopus 로고    scopus 로고
    • Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation
    • Zillmann A., Luther T., Müller I., et al. Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation. Biochem Biophys Res Commun 2001, 281:603-609.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 603-609
    • Zillmann, A.1    Luther, T.2    Müller, I.3
  • 40
    • 0037362704 scopus 로고    scopus 로고
    • Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets
    • Müller I., Klocke A., Alex M., et al. Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J 2003, 17:476-478.
    • (2003) FASEB J , vol.17 , pp. 476-478
    • Müller, I.1    Klocke, A.2    Alex, M.3
  • 41
    • 38949185741 scopus 로고    scopus 로고
    • Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer
    • Egorina E.M., Sovershaev M.A., Olsen J.O., Østerud B. Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer. Blood 2008, 111:1208-1216.
    • (2008) Blood , vol.111 , pp. 1208-1216
    • Egorina, E.M.1    Sovershaev, M.A.2    Olsen, J.O.3    Østerud, B.4
  • 42
    • 0021180126 scopus 로고
    • A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets
    • Hsu-Lin S., Berman C.L., Furie B.C., August D., Furie B. A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets. J Biol Chem 1984, 259:9121-9126.
    • (1984) J Biol Chem , vol.259 , pp. 9121-9126
    • Hsu-Lin, S.1    Berman, C.L.2    Furie, B.C.3    August, D.4    Furie, B.5
  • 43
    • 0024357563 scopus 로고
    • PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes
    • Larsen E., Celi A., Gilbert G.E., et al. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 1989, 59:305-312.
    • (1989) Cell , vol.59 , pp. 305-312
    • Larsen, E.1    Celi, A.2    Gilbert, G.E.3
  • 44
    • 0022221113 scopus 로고
    • A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation
    • Stenberg P.E., McEver R.P., Shuman M.A., Jacques Y.V., Bainton D.F. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol 1985, 101:880-886.
    • (1985) J Cell Biol , vol.101 , pp. 880-886
    • Stenberg, P.E.1    McEver, R.P.2    Shuman, M.A.3    Jacques, Y.V.4    Bainton, D.F.5
  • 45
    • 0024580737 scopus 로고
    • PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells
    • Bonfanti R., Furie B.C., Furie B., Wagner D.D. PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 1989, 73:1109-1112.
    • (1989) Blood , vol.73 , pp. 1109-1112
    • Bonfanti, R.1    Furie, B.C.2    Furie, B.3    Wagner, D.D.4
  • 46
    • 0034846702 scopus 로고    scopus 로고
    • Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation
    • McEver R.P. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost 2001, 86:746-756.
    • (2001) Thromb Haemost , vol.86 , pp. 746-756
    • McEver, R.P.1
  • 47
    • 0034678355 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo
    • Frenette P.S., Denis C.V., Weiss L., et al. P-selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med 2000, 191:1413-1422.
    • (2000) J Exp Med , vol.191 , pp. 1413-1422
    • Frenette, P.S.1    Denis, C.V.2    Weiss, L.3
  • 48
    • 0034648016 scopus 로고    scopus 로고
    • Density-dependent induction of TNF-alpha release from human monocytes by immobilized P-selectin
    • Koike J., Nagata K., Kudo S., Tsuji T., Irimura T. Density-dependent induction of TNF-alpha release from human monocytes by immobilized P-selectin. FEBS Lett 2000, 477:84-88.
    • (2000) FEBS Lett , vol.477 , pp. 84-88
    • Koike, J.1    Nagata, K.2    Kudo, S.3    Tsuji, T.4    Irimura, T.5
  • 49
    • 0028035107 scopus 로고
    • Induction of superoxide anion production from monocytes and neutrophils by activated platelets through the P-selectin-sialyl Lewis X interaction
    • Tsuji T., Nagata K., Koike J., Todoroki N., Irimura T. Induction of superoxide anion production from monocytes and neutrophils by activated platelets through the P-selectin-sialyl Lewis X interaction. J Leukoc Biol 1994, 56:583-587.
    • (1994) J Leukoc Biol , vol.56 , pp. 583-587
    • Tsuji, T.1    Nagata, K.2    Koike, J.3    Todoroki, N.4    Irimura, T.5
  • 50
    • 0028557209 scopus 로고
    • P-selectin induces the expression of tissue factor on monocytes
    • Celi A., Pellegrini G., Lorenzet R., et al. P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A 1994, 91:8767-8771.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8767-8771
    • Celi, A.1    Pellegrini, G.2    Lorenzet, R.3
  • 52
    • 33644801469 scopus 로고    scopus 로고
    • The interactions between inflammation and coagulation
    • Esmon C.T. The interactions between inflammation and coagulation. Br J Haematol 2005, 131:417-430.
    • (2005) Br J Haematol , vol.131 , pp. 417-430
    • Esmon, C.T.1
  • 53
    • 33750312909 scopus 로고    scopus 로고
    • Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage
    • Mollen K.P., Anand R.J., Tsung A., Prince J.M., Levy R.M., Billiar T.R. Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock 2006, 26:430-437.
    • (2006) Shock , vol.26 , pp. 430-437
    • Mollen, K.P.1    Anand, R.J.2    Tsung, A.3    Prince, J.M.4    Levy, R.M.5    Billiar, T.R.6
  • 54
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow J.C., Young D.W., Golenbock D.T., Christ W.J., Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999, 274:10689-10692.
    • (1999) J Biol Chem , vol.274 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 55
    • 34147188469 scopus 로고    scopus 로고
    • Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
    • Clark S.R., Ma A.C., Tavener S.A., et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 2007, 13:463-469.
    • (2007) Nat Med , vol.13 , pp. 463-469
    • Clark, S.R.1    Ma, A.C.2    Tavener, S.A.3
  • 56
    • 39549099917 scopus 로고    scopus 로고
    • Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis
    • Ma A.C., Kubes P. Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis. J Thromb Haemost 2008, 6:415-420.
    • (2008) J Thromb Haemost , vol.6 , pp. 415-420
    • Ma, A.C.1    Kubes, P.2
  • 57
    • 59649117667 scopus 로고    scopus 로고
    • Molecular biology of inflammation and sepsis: a primer
    • Cinel I., Opal S.M. Molecular biology of inflammation and sepsis: a primer. Crit Care Med 2009, 37:291-304.
    • (2009) Crit Care Med , vol.37 , pp. 291-304
    • Cinel, I.1    Opal, S.M.2
  • 58
    • 0032529677 scopus 로고    scopus 로고
    • Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106)
    • Kaplanski G., Marin V., Fabrigoule M., et al. Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106). Blood 1998, 92:1259-1267.
    • (1998) Blood , vol.92 , pp. 1259-1267
    • Kaplanski, G.1    Marin, V.2    Fabrigoule, M.3
  • 59
    • 84859698558 scopus 로고    scopus 로고
    • The roles of thrombin and protease-activated receptors in inflammation
    • Ma L., Dorling A. The roles of thrombin and protease-activated receptors in inflammation. Semin Immunopathol 2012, 34:63-72.
    • (2012) Semin Immunopathol , vol.34 , pp. 63-72
    • Ma, L.1    Dorling, A.2
  • 60
    • 0026004729 scopus 로고
    • Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils
    • Lorant D.E., Patel K.D., McIntyre T.M., McEver R.P., Prescott S.M., Zimmerman G.A. Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils. J Cell Biol 1991, 115:223-234.
    • (1991) J Cell Biol , vol.115 , pp. 223-234
    • Lorant, D.E.1    Patel, K.D.2    McIntyre, T.M.3    McEver, R.P.4    Prescott, S.M.5    Zimmerman, G.A.6
  • 61
    • 0032525041 scopus 로고    scopus 로고
    • Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation
    • Johnson K., Choi Y., DeGroot E., Samuels I., Creasey A., Aarden L. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation. J Immunol 1998, 160:5130-5135.
    • (1998) J Immunol , vol.160 , pp. 5130-5135
    • Johnson, K.1    Choi, Y.2    DeGroot, E.3    Samuels, I.4    Creasey, A.5    Aarden, L.6
  • 63
  • 64
    • 1642279517 scopus 로고    scopus 로고
    • Protease-activated receptors: contribution to physiology and disease
    • Ossovskaya V.S., Bunnett N.W. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 2004, 84:579-621.
    • (2004) Physiol Rev , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 65
    • 15844401726 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
    • Nystedt S., Ramakrishnan V., Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 1996, 271:14910-14915.
    • (1996) J Biol Chem , vol.271 , pp. 14910-14915
    • Nystedt, S.1    Ramakrishnan, V.2    Sundelin, J.3
  • 66
    • 0033527565 scopus 로고    scopus 로고
    • Coagulation factors IA, VI and Xa induce cell signaling leading to up-regulation of the egr-1 gene
    • Camerer E., Rottingen J.A., Gjernes E., et al. Coagulation factors IA, VI and Xa induce cell signaling leading to up-regulation of the egr-1 gene. J Biol Chem 1999, 274:32225-32233.
    • (1999) J Biol Chem , vol.274 , pp. 32225-32233
    • Camerer, E.1    Rottingen, J.A.2    Gjernes, E.3
  • 67
  • 68
    • 37049012509 scopus 로고    scopus 로고
    • The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
    • Bae J.S., Yang L., Manithody C., Rezaie A.R. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 2007, 110:3909-3916.
    • (2007) Blood , vol.110 , pp. 3909-3916
    • Bae, J.S.1    Yang, L.2    Manithody, C.3    Rezaie, A.R.4
  • 69
    • 0031306802 scopus 로고    scopus 로고
    • Thrombin activates nuclear factor-kappaB and potentiates endothelial cell activation by TNF
    • Anrather D., Millan M.T., Palmetshofer A., et al. Thrombin activates nuclear factor-kappaB and potentiates endothelial cell activation by TNF. J Immunol 1997, 159:5620-5628.
    • (1997) J Immunol , vol.159 , pp. 5620-5628
    • Anrather, D.1    Millan, M.T.2    Palmetshofer, A.3
  • 70
    • 0346749409 scopus 로고    scopus 로고
    • Endothelial responses to bacterial toxins in sepsis
    • Grandel U., Grimminger F. Endothelial responses to bacterial toxins in sepsis. Crit Rev Immunol 2003, 23:267-299.
    • (2003) Crit Rev Immunol , vol.23 , pp. 267-299
    • Grandel, U.1    Grimminger, F.2
  • 71
    • 32844469977 scopus 로고    scopus 로고
    • Lipopolysaccharide signaling in endothelial cells
    • Dauphinee S.M., Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab Invest 2006, 86:9-22.
    • (2006) Lab Invest , vol.86 , pp. 9-22
    • Dauphinee, S.M.1    Karsan, A.2
  • 72
    • 84857766493 scopus 로고    scopus 로고
    • Endothelium-role in regulation of coagulation and inflammation
    • van Hinsbergh V.W. Endothelium-role in regulation of coagulation and inflammation. Semin Immunopathol 2012, 34:93-106.
    • (2012) Semin Immunopathol , vol.34 , pp. 93-106
    • van Hinsbergh, V.W.1
  • 73
    • 0026025457 scopus 로고
    • Role of antithrombin III as a regulator of in vivo coagulation
    • Bauer K.A., Rosenberg R.D. Role of antithrombin III as a regulator of in vivo coagulation. Semin Hematol 1991, 28:10-18.
    • (1991) Semin Hematol , vol.28 , pp. 10-18
    • Bauer, K.A.1    Rosenberg, R.D.2
  • 74
    • 0035293659 scopus 로고    scopus 로고
    • Antithrombin reduces mesenteric venular leukocyte interactions and small intestine injury in endotoxemic rats
    • Nevière R., Tournoys A., Mordon S., et al. Antithrombin reduces mesenteric venular leukocyte interactions and small intestine injury in endotoxemic rats. Shock 2001, 15:220-225.
    • (2001) Shock , vol.15 , pp. 220-225
    • Nevière, R.1    Tournoys, A.2    Mordon, S.3
  • 75
    • 0035007071 scopus 로고    scopus 로고
    • Inhibitory effects of antithrombin III against leukocyte rolling and infiltration during endotoxin-induced uveitis in rats
    • Yamashiro K., Kiryu J., Tsujikawa A., et al. Inhibitory effects of antithrombin III against leukocyte rolling and infiltration during endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci 2001, 42:1553-1560.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1553-1560
    • Yamashiro, K.1    Kiryu, J.2    Tsujikawa, A.3
  • 76
    • 0031930384 scopus 로고    scopus 로고
    • The anti-inflammatory properties of antithrombin III: new therapeutic implications
    • Okajima K., Uchiba M. The anti-inflammatory properties of antithrombin III: new therapeutic implications. Semin Thromb Hemost 1998, 24:27-32.
    • (1998) Semin Thromb Hemost , vol.24 , pp. 27-32
    • Okajima, K.1    Uchiba, M.2
  • 77
    • 0036625064 scopus 로고    scopus 로고
    • Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cells
    • Oelschläger C., Römisch J., Staubitz A., et al. Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cells. Blood 2002, 99:4015-4020.
    • (2002) Blood , vol.99 , pp. 4015-4020
    • Oelschläger, C.1    Römisch, J.2    Staubitz, A.3
  • 78
    • 0035144440 scopus 로고    scopus 로고
    • Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood
    • Souter P.J., Thomas S., Hubbard A.R., Poole S., Römisch J., Gray E. Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood. Crit Care Med 2001, 29:134-139.
    • (2001) Crit Care Med , vol.29 , pp. 134-139
    • Souter, P.J.1    Thomas, S.2    Hubbard, A.R.3    Poole, S.4    Römisch, J.5    Gray, E.6
  • 80
    • 0022254373 scopus 로고
    • Substitution of antithrombin III in shock and DIC: a randomized study
    • Blauhut B., Kramar H., Vinazzer H., Bergmann H. Substitution of antithrombin III in shock and DIC: a randomized study. Thromb Res 1985, 39:81-89.
    • (1985) Thromb Res , vol.39 , pp. 81-89
    • Blauhut, B.1    Kramar, H.2    Vinazzer, H.3    Bergmann, H.4
  • 81
    • 0035904368 scopus 로고    scopus 로고
    • Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial
    • Warren B.L., Eid A., Singer P., et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 2001, 286:1869-1878.
    • (2001) JAMA , vol.286 , pp. 1869-1878
    • Warren, B.L.1    Eid, A.2    Singer, P.3
  • 82
    • 0025051259 scopus 로고
    • Human recombinant interleukin-1 beta- and tumor necrosis factor alpha-mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells
    • Kobayashi M., Shimada K., Ozawa T. Human recombinant interleukin-1 beta- and tumor necrosis factor alpha-mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells. J Cell Physiol 1990, 144:383-390.
    • (1990) J Cell Physiol , vol.144 , pp. 383-390
    • Kobayashi, M.1    Shimada, K.2    Ozawa, T.3
  • 83
    • 0034651773 scopus 로고    scopus 로고
    • Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli
    • Minnema M.C., Chang A.C., Jansen P.M., et al. Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli. Blood 2000, 95:1117-1123.
    • (2000) Blood , vol.95 , pp. 1117-1123
    • Minnema, M.C.1    Chang, A.C.2    Jansen, P.M.3
  • 84
    • 84857860942 scopus 로고    scopus 로고
    • Thrombomodulin and its role in inflammation
    • Conway E.M. Thrombomodulin and its role in inflammation. Semin Immunopathol 2012, 34:107-125.
    • (2012) Semin Immunopathol , vol.34 , pp. 107-125
    • Conway, E.M.1
  • 85
    • 33746636356 scopus 로고    scopus 로고
    • The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis
    • Van de Wouwer M., Plaisance S., De Vriese A., et al. The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis. J Thromb Haemost 2006, 4:1813-1824.
    • (2006) J Thromb Haemost , vol.4 , pp. 1813-1824
    • Van de Wouwer, M.1    Plaisance, S.2    De Vriese, A.3
  • 86
    • 55749115786 scopus 로고    scopus 로고
    • Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response
    • Shi C.S., Shi G.Y., Hsiao S.M., et al. Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response. Blood 2008, 112:3661-3670.
    • (2008) Blood , vol.112 , pp. 3661-3670
    • Shi, C.S.1    Shi, G.Y.2    Hsiao, S.M.3
  • 87
    • 20944436774 scopus 로고    scopus 로고
    • The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
    • Abeyama K., Stern D.M., Ito Y., et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest 2005, 115:1267-1274.
    • (2005) J Clin Invest , vol.115 , pp. 1267-1274
    • Abeyama, K.1    Stern, D.M.2    Ito, Y.3
  • 88
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
    • Lotze M.T., Tracey K.J. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005, 5:331-342.
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 89
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H., Bloom O., Zhang M., et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999, 285:248-251.
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 90
    • 33845513582 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
    • Saito H., Maruyama I., Shimazaki S., et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost 2007, 5:31-41.
    • (2007) J Thromb Haemost , vol.5 , pp. 31-41
    • Saito, H.1    Maruyama, I.2    Shimazaki, S.3
  • 91
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • Cheng T., Liu D., Griffin J.H., et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003, 9:338-342.
    • (2003) Nat Med , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3
  • 92
    • 17044427680 scopus 로고    scopus 로고
    • Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    • Feistritzer C., Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 2005, 105:3178-3184.
    • (2005) Blood , vol.105 , pp. 3178-3184
    • Feistritzer, C.1    Riewald, M.2
  • 94
    • 10244229104 scopus 로고    scopus 로고
    • Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
    • Nick J.A., Coldren C.D., Geraci M.W., et al. Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood 2004, 104:3878-3885.
    • (2004) Blood , vol.104 , pp. 3878-3885
    • Nick, J.A.1    Coldren, C.D.2    Geraci, M.W.3
  • 95
    • 2942738936 scopus 로고    scopus 로고
    • Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway
    • Joyce D.E., Nelson D.R., Grinnell B.W. Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway. Crit Care Med 2004, 32:S280-S286.
    • (2004) Crit Care Med , vol.32
    • Joyce, D.E.1    Nelson, D.R.2    Grinnell, B.W.3
  • 96
    • 0036339949 scopus 로고    scopus 로고
    • Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes
    • Yuksel M., Okajima K., Uchiba M., Horiuchi S., Okabe H. Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes. Thromb Haemost 2002, 88:267-273.
    • (2002) Thromb Haemost , vol.88 , pp. 267-273
    • Yuksel, M.1    Okajima, K.2    Uchiba, M.3    Horiuchi, S.4    Okabe, H.5
  • 97
    • 70449112006 scopus 로고    scopus 로고
    • Sepsis: the dark side of histones
    • Chaput C., Zychlinsky A. Sepsis: the dark side of histones. Nat Med 2009, 15:1245-1246.
    • (2009) Nat Med , vol.15 , pp. 1245-1246
    • Chaput, C.1    Zychlinsky, A.2
  • 98
    • 70350497110 scopus 로고    scopus 로고
    • Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice
    • Song D., Ye X., Xu H., Liu S.F. Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood 2009, 114:2521-2529.
    • (2009) Blood , vol.114 , pp. 2521-2529
    • Song, D.1    Ye, X.2    Xu, H.3    Liu, S.F.4
  • 99
    • 3242775982 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    • Dellinger R.P., Carlet J.M., Masur H., et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004, 32:858-873.
    • (2004) Crit Care Med , vol.32 , pp. 858-873
    • Dellinger, R.P.1    Carlet, J.M.2    Masur, H.3
  • 100
    • 23844505326 scopus 로고    scopus 로고
    • Bioethics, the Surviving Sepsis Campaign, and the industry
    • Wiedermann C.J. Bioethics, the Surviving Sepsis Campaign, and the industry. Wien Klin Wochenschr 2005, 117:442-444.
    • (2005) Wien Klin Wochenschr , vol.117 , pp. 442-444
    • Wiedermann, C.J.1
  • 101
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard G.R., Vincent J.L., Laterre P.F., et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 102
    • 33645106226 scopus 로고    scopus 로고
    • When a single pivotal trial should not be enough-the case of drotrecogin-alfa (activated)
    • Wiedermann C.J. When a single pivotal trial should not be enough-the case of drotrecogin-alfa (activated). Intensive Care Med 2006, 32:604.
    • (2006) Intensive Care Med , vol.32 , pp. 604
    • Wiedermann, C.J.1
  • 104
    • 33746017989 scopus 로고    scopus 로고
    • Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells
    • Feistritzer C., Schuepbach R.A., Mosnier L.O., et al. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem 2006, 281:20077-20084.
    • (2006) J Biol Chem , vol.281 , pp. 20077-20084
    • Feistritzer, C.1    Schuepbach, R.A.2    Mosnier, L.O.3
  • 105
    • 18844480902 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia
    • de Jonge E., Dekkers P.E., Creasey A.A., et al. Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia. Blood 2000, 95:1124-1129.
    • (2000) Blood , vol.95 , pp. 1124-1129
    • de Jonge, E.1    Dekkers, P.E.2    Creasey, A.A.3
  • 106
    • 34548835747 scopus 로고    scopus 로고
    • Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor
    • Tang H., Ivanciu L., Popescu N., et al. Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Am J Pathol 2007, 171:1066-1077.
    • (2007) Am J Pathol , vol.171 , pp. 1066-1077
    • Tang, H.1    Ivanciu, L.2    Popescu, N.3
  • 107
    • 0035128763 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor (TFPI) levels in the plasma and urine of children with meningococcal disease
    • Eling M., Stephens A.C., Oragui E.E., Rivers R.P., Levin M. Tissue factor pathway inhibitor (TFPI) levels in the plasma and urine of children with meningococcal disease. Thromb Haemost 2001, 85:240-244.
    • (2001) Thromb Haemost , vol.85 , pp. 240-244
    • Eling, M.1    Stephens, A.C.2    Oragui, E.E.3    Rivers, R.P.4    Levin, M.5
  • 108
    • 63149094677 scopus 로고    scopus 로고
    • A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia
    • Laterre P.F., Opal S.M., Abraham E., et al. A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia. Crit Care 2009, 13:R36.
    • (2009) Crit Care , vol.13
    • Laterre, P.F.1    Opal, S.M.2    Abraham, E.3
  • 109
    • 0035159740 scopus 로고    scopus 로고
    • Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study
    • Abraham E., Reinhart K., Svoboda P., et al. Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study. Crit Care Med 2001, 29:2081-2089.
    • (2001) Crit Care Med , vol.29 , pp. 2081-2089
    • Abraham, E.1    Reinhart, K.2    Svoboda, P.3
  • 110
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial
    • Abraham E., Reinhart K., Opal S., et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 2003, 290:238-247.
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3


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